The Chromosomal Imbalance Theory of Cancer, Rasnick, David
Автор: B. Michael Ghadimi; Thomas Ried Название: Chromosomal Instability in Cancer Cells ISBN: 3319202901 ISBN-13(EAN): 9783319202907 Издательство: Springer Рейтинг: Цена: 11878.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Автор: Thomas Liehr Название: Benign & Pathological Chromosomal Imbalances, ISBN: 0124046312 ISBN-13(EAN): 9780124046313 Издательство: Elsevier Science Рейтинг: Цена: 11620.00 р. Наличие на складе: Поставка под заказ.
Описание: Benign & Pathological Chromosomal Imbalances systematically clarifies the disease implications of cytogenetically visible copy number variants (CG-CNV) using cytogenetic assessment of heterochromatic or euchromatic DNA variants. While variants of several megabasepair can be present in the human genome without clinical consequence, visually distinguishing these benign areas from disease implications does not always occur to practitioners accustomed to costly molecular profiling methods such as FISH, aCGH, and NGS. . As technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment. Knowledge of the rare but recurrent rearrangements unfamiliar to practitioners saves time and money for molecular cytogeneticists and genetics counselors, helping to distinguish benign from harmful CG-CNV. It also supports them in deciding which molecular cytogenetics tools to deploy.
Автор: Janet D. Rowley; Michelle M. Le Beau; Terence H. R Название: Chromosomal Translocations and Genome Rearrangements in Cancer ISBN: 331919982X ISBN-13(EAN): 9783319199825 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This guide discusses chromosomal abnormalities and how best to report and communicate lab findings in research and clinical settings. Providing a standard approach to writing cytogenetic laboratory reports, the guide further covers useful guidance on implementing International System for Human Cytogenetic Nomenclature in reports.
Автор: Shondra M. Pruett-Miller Название: Chromosomal Mutagenesis ISBN: 1493918613 ISBN-13(EAN): 9781493918614 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This new edition explores current and emerging mutagenesis methods focusing specifically on mammalian systems and commonly used model organisms through comprehensive coverage and detailed protocols.
Автор: G?nter Obe; A.T. Natarajan Название: Chromosomal Aberrations ISBN: 3642756840 ISBN-13(EAN): 9783642756849 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Chromosomale Mutationen sind eine der m-glichen Ursachen f}r Ver{nderungen der Erbinformation. Neben grunds{tzlichen As- pekten, wie Reparaturmechanismen der Zelle oder Ursachen von Chromosomenver{nderungen, werden angewandte Aspekte, z.B. Chromosomen als Testindikatoren der Toxizit{t, behandelt.
Автор: G. Shashidhar Pai Название: Handbook of Chromosomal Syndromes ISBN: 047137217X ISBN-13(EAN): 9780471372172 Издательство: Wiley Рейтинг: Цена: 26762.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This comprehensive reference provides a pictorial and descriptive account of approximately 200 chromosomal aneuploidy syndromes. It focuses exclusively on clinical syndromes due to chromosomal abnormalities.
Автор: Uchiumi, Fumiaki (professor Of Pharmaceutical Sciences, Tokyo University Of Science, Japan) Название: Bidirectional gene promoters ISBN: 0128187875 ISBN-13(EAN): 9780128187876 Издательство: Elsevier Science Рейтинг: Цена: 19370.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: He is exactly what this age needs, a real voice of universal spirituality. His appeal is urgent, human and sacred. DAN CRUSEY Sidney, Ohio Each era has its own prophet poets. Russia has been praying and is praying poems by Pushkin, a holy name for every Russian. Ayaz seems to touch us with that sensitivity, inspiring and changing the rhythm of our breathing. SEBARITA KAKHOVSKAYA Ukraine His words transform you through a subtle Alchemy process, and you suddenly travel from a Neophyte to the Connoisseur of Mysteries. His poetry is a gateway to the stars ELLURA ZURIA Rhn, Germany Reading Ayaz is akin to a journey into the
Описание: This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.
Автор: Frederick De Serres Название: Genetic Consequences of Nucleotide Pool Imbalance ISBN: 1461294886 ISBN-13(EAN): 9781461294887 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is concerned with the genetic consequences of nu- cleotide pool imbalance. This book grew out of a Conference on "Genetic Consequences of Nu- cleotide Pool Imbalance" which was held at the National Institute of Environmental Health Sciences on May 9-11, 1983.
Автор: B. Michael Ghadimi; Thomas Ried Название: Chromosomal Instability in Cancer Cells ISBN: 3319349627 ISBN-13(EAN): 9783319349626 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer.
Автор: Shondra M. Pruett-Miller Название: Chromosomal Mutagenesis ISBN: 1493955411 ISBN-13(EAN): 9781493955411 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This new edition explores current and emerging mutagenesis methods focusing specifically on mammalian systems and commonly used model organisms through comprehensive coverage and detailed protocols.
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