Chromosomal Instability in Cancer Cells, B. Michael Ghadimi; Thomas Ried

Автор: Janet D. Rowley; Michelle M. Le Beau; Terence H. R
Название: Chromosomal Translocations and Genome Rearrangements in Cancer
ISBN: 331919982X ISBN-13(EAN): 9783319199825
Издательство: Springer
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Автор: Thomas Liehr
Название: Benign & Pathological Chromosomal Imbalances,
ISBN: 0124046312 ISBN-13(EAN): 9780124046313
Издательство: Elsevier Science
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Описание: Benign & Pathological Chromosomal Imbalances systematically clarifies the disease implications of cytogenetically visible copy number variants (CG-CNV) using cytogenetic assessment of heterochromatic or euchromatic DNA variants. While variants of several megabasepair can be present in the human genome without clinical consequence, visually distinguishing these benign areas from disease implications does not always occur to practitioners accustomed to costly molecular profiling methods such as FISH, aCGH, and NGS. . As technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment. Knowledge of the rare but recurrent rearrangements unfamiliar to practitioners saves time and money for molecular cytogeneticists and genetics counselors, helping to distinguish benign from harmful CG-CNV. It also supports them in deciding which molecular cytogenetics tools to deploy.

Автор: G?nter Obe; Vijayalaxmi
Название: Chromosomal Alterations
ISBN: 3642090591 ISBN-13(EAN): 9783642090592
Издательство: Springer
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Цена: 36570.00 р.
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Описание: The book provides a comprehensive review of basic and applied aspects of cytogenetics and thus is of intense interest to all those interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields.

Автор: G. Shashidhar Pai
Название: Handbook of Chromosomal Syndromes
ISBN: 047137217X ISBN-13(EAN): 9780471372172
Издательство: Wiley
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Цена: 26762.00 р.
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Описание: This comprehensive reference provides a pictorial and descriptive account of approximately 200 chromosomal aneuploidy syndromes. It focuses exclusively on clinical syndromes due to chromosomal abnormalities.

Автор: Chris Maxwell; Cal Roskelley
Название: Genomic Instability and Cancer Metastasis
ISBN: 3319352954 ISBN-13(EAN): 9783319352954
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse.

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319202901 ISBN-13(EAN): 9783319202907
Издательство: Springer
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Цена: 11878.00 р.
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Автор: G?nter Obe; A.T. Natarajan
Название: Chromosomal Aberrations
ISBN: 3642756840 ISBN-13(EAN): 9783642756849
Издательство: Springer
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Цена: 15372.00 р.
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Описание: Chromosomale Mutationen sind eine der m-glichen Ursachen f}r Ver{nderungen der Erbinformation. Neben grunds{tzlichen As- pekten, wie Reparaturmechanismen der Zelle oder Ursachen von Chromosomenver{nderungen, werden angewandte Aspekte, z.B. Chromosomen als Testindikatoren der Toxizit{t, behandelt.

Автор: Frank J. III Rauscher; Peter K. Vogt
Название: Chromosomal Translocations and Oncogenic Transcription Factors
ISBN: 3642644244 ISBN-13(EAN): 9783642644245
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Regulation of gene expression at the level of transcription is one of the major determinants of proper cellular proliferation and differentiation. This volume gives insights into how normal programs of gene expression can be subverted by the action of single transcription factors resulting in a specific tumor type.

Автор: G?nter Obe; Adayapalam T. Natarajan
Название: Chromosomal Alterations
ISBN: 3642788890 ISBN-13(EAN): 9783642788895
Издательство: Springer
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Цена: 15672.00 р.
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Описание: With contributions by numerous experts

Автор: Greg Davis; Kevin J. Kayser
Название: Chromosomal Mutagenesis
ISBN: 161737833X ISBN-13(EAN): 9781617378331
Издательство: Springer
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Цена: 16769.00 р.
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Описание: In Chromosomal Mutagenesis, a team of experts provide a variety of chromosomal manipulation techniques, including insertional gene disruptions, gene knockouts, stimulated homologous recombination techniques and other novel tools, for both prokaryotic and eukaryotic organisms, and attempt to expand the genetic toolbox beyond model organisms.

Автор: Shondra M. Pruett-Miller
Название: Chromosomal Mutagenesis
ISBN: 1493955411 ISBN-13(EAN): 9781493955411
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This new edition explores current and emerging mutagenesis methods focusing specifically on mammalian systems and commonly used model organisms through comprehensive coverage and detailed protocols.

Автор: Enrico Mihich; Leland Hartwell
Название: Genomic Instability and Immortality in Cancer
ISBN: 1461374480 ISBN-13(EAN): 9781461374480
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Proceedings of the Eighth Annual Pezcoller Symposium held in Trento, Italy, June 17-19, 1996