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Genomic Instability and Immortality in Cancer, Enrico Mihich; Leland Hartwell


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Автор: Enrico Mihich; Leland Hartwell
Название:  Genomic Instability and Immortality in Cancer
ISBN: 9781461374480
Издательство: Springer
Классификация:


ISBN-10: 1461374480
Обложка/Формат: Paperback
Страницы: 251
Вес: 0.46 кг.
Дата издания: 24.10.2012
Серия: Pezcoller Foundation Symposia
Язык: English
Размер: 254 x 178 x 14
Основная тема: Medicine & Public Health
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Proceedings of the Eighth Annual Pezcoller Symposium held in Trento, Italy, June 17-19, 1996


Chromosomal Instability in Cancer Cells

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319349627 ISBN-13(EAN): 9783319349626
Издательство: Springer
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Цена: 11179.00 р.
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer.

Genomic Diversity

Автор: Surinder Singh Papiha; Ranjan Deka; Ranajit Chakra
Название: Genomic Diversity
ISBN: 1461369142 ISBN-13(EAN): 9781461369141
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Proceedings of the Symposium on Molecular Anthropology in the 21st Century, held during the 14th International Congress of the Association of Anthropological and Ethnological Sciences, 26 July to 1 August, 1998, in Williamsburg, Virginia, USA

Genomic Instability and Cancer Metastasis

Автор: Chris Maxwell; Cal Roskelley
Название: Genomic Instability and Cancer Metastasis
ISBN: 3319352954 ISBN-13(EAN): 9783319352954
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse.

Chromosomal Instability in Cancer Cells

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319202901 ISBN-13(EAN): 9783319202907
Издательство: Springer
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Цена: 11878.00 р.
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Genomic instability and cancer metastasis

Название: Genomic instability and cancer metastasis
ISBN: 3319121359 ISBN-13(EAN): 9783319121352
Издательство: Springer
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Цена: 22203.00 р.
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Описание: Genomic Instability and Cancer Metastasis

Genetic Instability and Tumorigenesis

Автор: Michael B. Kastan
Название: Genetic Instability and Tumorigenesis
ISBN: 3642644341 ISBN-13(EAN): 9783642644344
Издательство: Springer
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Цена: 18167.00 р.
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Описание: KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe- notypic changes in somatic cells. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual.

Trinucleotide Diseases and Instability

Автор: Ben A. Oostra
Название: Trinucleotide Diseases and Instability
ISBN: 3662225654 ISBN-13(EAN): 9783662225653
Издательство: Springer
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Описание: Trinu- cleotide repeat diseases are ideal subjects for direct testing because the muta- tion is almost exclusively of the same type and there is an extremely low occur- ance of new mutations in these diseases.

Genome Instability

Автор: Marco Muzi-Falconi; Grant W Brown
Название: Genome Instability
ISBN: 1493973053 ISBN-13(EAN): 9781493973057
Издательство: Springer
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Цена: 22359.00 р.
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Описание:

1. The A-like Faker Assay for Measuring Yeast Chromosome III Stability

Carolina A. Novoa, J. Sidney Ang, and Peter C. Stirling

2. The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast

Supipi Duffy and Philip Hieter

3. Measuring Mutation Rates using the Luria-Delbrьck Fluctuation Assay

Gregory I. Lang

4. Molecular Genetic Characterization of Mutagenesis Using a Highly Sensitized Single-Stranded DNA Reporter System in Budding Yeast

Kin Chan

5. Analyzing Genome Rearrangements in Saccharomyces cerevisiae

Anjana Srivatsan, Christopher D. Putnam, and Richard D. Kolodner

6. High Resolution Mapping of Modified DNA Nucleobases using Excision Repair Enzymes

Monica Ransom, D. Suzi Bryan and Jay R. Hesselberth

7. Integrated Microarray-based Tools for Detection of Genomic DNA Damage and Repair Mechanisms

Patrick van Eijk, Yumin Teng, Mark R. Bennet, Katie E. Evans, James R. Powell, Richard M. Webster, and Simon H. Reed

8. Study of UV-induced DNA Repair Factor Recruitment: Kinetics and Dynamics

Sertic S., Roma S., Plevani P., Lazzaro F., and Muzi-Falconi M.

9. Inserting Site-specific DNA Lesions into Whole Genomes

Vincent Pagиs and Robert P Fuchs

10. A qPCR-based Protocol to Quantify DSB Resection

Matteo Ferrari, Shyam Twayana, Federica Marini, and Achille Pellicioli

11. Alkaline Denaturing Southern Blot Analysis to Monitor Double-strand Break Processing

Chiara Vittoria Colombo, Luca Menin, and Michela Clerici

12. Single Molecule Analysis of Resection Tracks

Pablo Huertas and Andrйs Cruz-Garcнa

13. Mapping DNA Breaks by Next-generation Sequencing

Laura Baranello, Fedor Kouzine, Damian Wojtowicz, Kairong Cui, Keji Zhao, Teresa M Przytycka, Giovanni Capranico, and David Levens

14. Genome-wide Profiling of DNA Double-strand Breaks by the BLESS and BLISS Methods

Reza Mirzazadeh, Tomasz Kallas, Magda Bienko, and Nicola Crosetto

15. DNA Replication Profiling using Deep Sequencing

Xanita Saayman, Cristina Ramos-Pйrez, and Grant W Brown

16. Quantitative Bromodeoxyuridine Immunoprecipitation Analyzed by High-Throughput Sequencing (qBrdU-seq or QBU)

Joanna E. Haye-Bertolozzi and Oscar M. Aparicio

17. Strand-specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast

Chuanhe Yu, Haiyun Gan, and Zhiguo Zhang

18. Analysis of Replicative Polymerase Usage by Ribonucleotide Incorporation

Andrea Keszthelyi, Izumi Miyabe, Katie Ptasińska, Yasukazu Daigaku, Karel Naiman, and Antony M. Carr

19. Dynamic Architecture of Eukaryotic DNA Replication Forks in vivo, Visualized by Electron Microscopy

Ralph Zellweger and Massimo Lopes

20. A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation

Nicolai B. Larsen, Ian D. Hickson, and Hocine W. Mankouri

21. Single Cell Gel Electrophoresis for the Detection of Genomic Ribonucleotides

Barbara Kind, Christine Wolf, Kerstin Engel, Alexander Rapp, M. Cristina Cardoso, and Min Ae Lee-Kirsch

22. Measuring the Levels of Ribonucleotides Embedded in Genomic DNA

Meroni A., Nava G.M., Sertic S., Plevani P., Muzi-Falconi M. and Lazzaro F.

23. Mapping Ribonucleotides Incorporated into DNA by Hydrolytic End-Sequencing

Clinton D. Orebaugh, Scott A. Lujan, Adam B. Burkholder, Anders R Clausen, and Thomas A. Kunkel

Cancer Informatics in the Post Genomic Era

Автор: Igor Jurisica; Dennis A. Wigle; Bill Wong
Название: Cancer Informatics in the Post Genomic Era
ISBN: 1441943447 ISBN-13(EAN): 9781441943446
Издательство: Springer
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Цена: 27951.00 р.
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Описание: Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools for analyzing data in the field of medical information science.

Array Comparative Genomic Hybridization

Автор: Diponkar Banerjee; Sohrab P. Shah
Название: Array Comparative Genomic Hybridization
ISBN: 1493959557 ISBN-13(EAN): 9781493959556
Издательство: Springer
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Цена: 20263.00 р.
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Описание: This Methods in Molecular Biology (TM) book explores the scope of what is possible today in documenting abnormalities associated with several human cancers. Offers materials and reagents lists, step-by-step protocols, troubleshooting tips, pitfalls and more.

Genomic Structural Variants

Автор: Lars Feuk
Название: Genomic Structural Variants
ISBN: 1493961896 ISBN-13(EAN): 9781493961894
Издательство: Springer
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Цена: 20263.00 р.
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Описание: This book reviews progress in the understanding of structural genetic variation and its implications for human disease, from the introduction of microarrays to current sequencing strategies. Covers major research and diagnostic technologies, and more.

Genomic Adaptability in Somatic Cell Specialization

Автор: Marie A. DiBerardino; Laurence D. Etkin
Название: Genomic Adaptability in Somatic Cell Specialization
ISBN: 1461568226 ISBN-13(EAN): 9781461568223
Издательство: Springer
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Цена: 6986.00 р.
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Описание: I am pleased to include this book as Volume 6 of Developmental Biology: A Comprehensive Synthesis. This series was established to create comprehensive treatises on specific topics in developmental biology.


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