Genomic Instability and Immortality in Cancer, Enrico Mihich; Leland Hartwell

Автор: Chris Maxwell; Cal Roskelley
Название: Genomic Instability and Cancer Metastasis
ISBN: 3319352954 ISBN-13(EAN): 9783319352954
Издательство: Springer
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Описание: Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse.

Название: Genomic instability and cancer metastasis
ISBN: 3319121359 ISBN-13(EAN): 9783319121352
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Описание: Genomic Instability and Cancer Metastasis

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319202901 ISBN-13(EAN): 9783319202907
Издательство: Springer
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319349627 ISBN-13(EAN): 9783319349626
Издательство: Springer
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer.

Автор: Michael B. Kastan
Название: Genetic Instability and Tumorigenesis
ISBN: 3642644341 ISBN-13(EAN): 9783642644344
Издательство: Springer
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Описание: KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe- notypic changes in somatic cells. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual.

Автор: Ben A. Oostra
Название: Trinucleotide Diseases and Instability
ISBN: 3662225654 ISBN-13(EAN): 9783662225653
Издательство: Springer
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Описание: Trinu- cleotide repeat diseases are ideal subjects for direct testing because the muta- tion is almost exclusively of the same type and there is an extremely low occur- ance of new mutations in these diseases.

Автор: Igor Jurisica; Dennis A. Wigle; Bill Wong
Название: Cancer Informatics in the Post Genomic Era
ISBN: 1441943447 ISBN-13(EAN): 9781441943446
Издательство: Springer
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Описание: Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools for analyzing data in the field of medical information science.

Автор: Diponkar Banerjee; Sohrab P. Shah
Название: Array Comparative Genomic Hybridization
ISBN: 1493959557 ISBN-13(EAN): 9781493959556
Издательство: Springer
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Описание: This Methods in Molecular Biology (TM) book explores the scope of what is possible today in documenting abnormalities associated with several human cancers. Offers materials and reagents lists, step-by-step protocols, troubleshooting tips, pitfalls and more.

Автор: Lars Feuk
Название: Genomic Structural Variants
ISBN: 1493961896 ISBN-13(EAN): 9781493961894
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Описание: This book reviews progress in the understanding of structural genetic variation and its implications for human disease, from the introduction of microarrays to current sequencing strategies. Covers major research and diagnostic technologies, and more.

Автор: Marie A. DiBerardino; Laurence D. Etkin
Название: Genomic Adaptability in Somatic Cell Specialization
ISBN: 1461568226 ISBN-13(EAN): 9781461568223
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Описание: I am pleased to include this book as Volume 6 of Developmental Biology: A Comprehensive Synthesis. This series was established to create comprehensive treatises on specific topics in developmental biology.

Автор: Surinder Singh Papiha; Ranjan Deka; Ranajit Chakra
Название: Genomic Diversity
ISBN: 1461369142 ISBN-13(EAN): 9781461369141
Издательство: Springer
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Описание: Proceedings of the Symposium on Molecular Anthropology in the 21st Century, held during the 14th International Congress of the Association of Anthropological and Ethnological Sciences, 26 July to 1 August, 1998, in Williamsburg, Virginia, USA