Trinucleotide Diseases and Instability, Ben A. Oostra
Автор: Yoshinori Kohwi; Cynthia T. McMurray Название: Trinucleotide Repeat Protocols ISBN: 1493959719 ISBN-13(EAN): 9781493959716 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Coverage in this volume includes an overview of trinucleotide repeat diseases, synaptic plasticity, embryonic stem (ES) cell-related protocols with a focus on HD, RNA-related protocols, and analysis of epigenetic modification in fragile X syndrome.
Автор: Yoshinori Kohwi; Cynthia T. McMurray Название: Trinucleotide Repeat Protocols ISBN: 1627034102 ISBN-13(EAN): 9781627034104 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Coverage in this volume includes an overview of trinucleotide repeat diseases, synaptic plasticity, embryonic stem (ES) cell-related protocols with a focus on HD, RNA-related protocols, and analysis of epigenetic modification in fragile X syndrome.
Автор: Yoshinori Kohwi Название: Trinucleotide Repeat Protocols ISBN: 1617374466 ISBN-13(EAN): 9781617374463 Издательство: Springer Рейтинг: Цена: 21661.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Trinucleotide repeats are relatively common in the human genome. These simple repeats have received much attention since epoch-making discoveries were made that particular trinucleotide repeats are expanded in the causal genes of human hereditary neurological disorders.
Автор: Gebhard Geiger Название: Evolutionary Instability ISBN: 3540518088 ISBN-13(EAN): 9783540518082 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The scope of this book can be described best as a compilation of papers presented to an imaginary interdisciplinary conference on philosophical and material problems of biosocial evolution. The conference is espe- cially designed to discuss unifying theoretical approaches to pheno- mena of both increasing structural complexity ("natural self-organi- sation") and biosocial adaptation. Among the contributors to the confe- rence are mathematical system theoretists, philosophers of science, theoretical population biologists, and social scientists. The only diffe- rence to a real conference of this kind is that all contributions are deli- vered by one and the same author, who also tries to integrate them to some higher degree than can normally be attained in conference papers. Technically, this integration amounts to the embedding of the biobeha- vioural concepts of evolutionarily stable and unstable strategies into the framework of the structure and stability of hierarchical systems. When embarking on my work on philosophical and interdisciplinary problems of the life sciences about 6 years ago, I decided not to contri- bute to the obscurantist talk of - horribile dictu - "emergence," "onto- logical reductionism" and the like contaminating the recent sociobio- logy debate. I rather found it a genuinely philosophical task to analyse this talk, and so I attempted to recast the relevant concepts and princip- les into a form allowing for definite conclusions. Among other things, which I hope the reader will find more pleasant, this attempt had some unfortunate effect, however.
Автор: Chris Maxwell; Cal Roskelley Название: Genomic Instability and Cancer Metastasis ISBN: 3319352954 ISBN-13(EAN): 9783319352954 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse.
Автор: B. Michael Ghadimi; Thomas Ried Название: Chromosomal Instability in Cancer Cells ISBN: 3319202901 ISBN-13(EAN): 9783319202907 Издательство: Springer Рейтинг: Цена: 11878.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.
Автор: Michael B. Kastan Название: Genetic Instability and Tumorigenesis ISBN: 3642644341 ISBN-13(EAN): 9783642644344 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe- notypic changes in somatic cells. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual.
Автор: B. Michael Ghadimi; Thomas Ried Название: Chromosomal Instability in Cancer Cells ISBN: 3319349627 ISBN-13(EAN): 9783319349626 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer.
Автор: Enrico Mihich; Leland Hartwell Название: Genomic Instability and Immortality in Cancer ISBN: 1461374480 ISBN-13(EAN): 9781461374480 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the Eighth Annual Pezcoller Symposium held in Trento, Italy, June 17-19, 1996
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