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Trinucleotide Diseases and Instability, Ben A. Oostra


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Автор: Ben A. Oostra
Название:  Trinucleotide Diseases and Instability
ISBN: 9783662225653
Издательство: Springer
Классификация:






ISBN-10: 3662225654
Обложка/Формат: Paperback
Страницы: 169
Вес: 0.26 кг.
Дата издания: 03.10.2013
Серия: Results and Problems in Cell Differentiation
Язык: English
Размер: 234 x 156 x 10
Основная тема: Life Sciences
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание: Trinu- cleotide repeat diseases are ideal subjects for direct testing because the muta- tion is almost exclusively of the same type and there is an extremely low occur- ance of new mutations in these diseases.


Chromosomal Instability in Cancer Cells

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319202901 ISBN-13(EAN): 9783319202907
Издательство: Springer
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Цена: 11878.00 р.
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Trinucleotide Repeat Protocols

Автор: Yoshinori Kohwi; Cynthia T. McMurray
Название: Trinucleotide Repeat Protocols
ISBN: 1493959719 ISBN-13(EAN): 9781493959716
Издательство: Springer
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Цена: 16769.00 р.
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Описание: Coverage in this volume includes an overview of trinucleotide repeat diseases, synaptic plasticity, embryonic stem (ES) cell-related protocols with a focus on HD, RNA-related protocols, and analysis of epigenetic modification in fragile X syndrome.

Trinucleotide Repeat Protocols

Автор: Yoshinori Kohwi
Название: Trinucleotide Repeat Protocols
ISBN: 1617374466 ISBN-13(EAN): 9781617374463
Издательство: Springer
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Цена: 21661.00 р.
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Описание: Trinucleotide repeats are relatively common in the human genome. These simple repeats have received much attention since epoch-making discoveries were made that particular trinucleotide repeats are expanded in the causal genes of human hereditary neurological disorders.

Evolutionary Instability

Автор: Gebhard Geiger
Название: Evolutionary Instability
ISBN: 3540518088 ISBN-13(EAN): 9783540518082
Издательство: Springer
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Цена: 15372.00 р.
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Описание: The scope of this book can be described best as a compilation of papers presented to an imaginary interdisciplinary conference on philosophical and material problems of biosocial evolution. The conference is espe- cially designed to discuss unifying theoretical approaches to pheno- mena of both increasing structural complexity ("natural self-organi- sation") and biosocial adaptation. Among the contributors to the confe- rence are mathematical system theoretists, philosophers of science, theoretical population biologists, and social scientists. The only diffe- rence to a real conference of this kind is that all contributions are deli- vered by one and the same author, who also tries to integrate them to some higher degree than can normally be attained in conference papers. Technically, this integration amounts to the embedding of the biobeha- vioural concepts of evolutionarily stable and unstable strategies into the framework of the structure and stability of hierarchical systems. When embarking on my work on philosophical and interdisciplinary problems of the life sciences about 6 years ago, I decided not to contri- bute to the obscurantist talk of - horribile dictu - "emergence," "onto- logical reductionism" and the like contaminating the recent sociobio- logy debate. I rather found it a genuinely philosophical task to analyse this talk, and so I attempted to recast the relevant concepts and princip- les into a form allowing for definite conclusions. Among other things, which I hope the reader will find more pleasant, this attempt had some unfortunate effect, however.

Developmental Instability: Its Origins and Evolutionary Implications

Автор: T.A. Markow
Название: Developmental Instability: Its Origins and Evolutionary Implications
ISBN: 0792326784 ISBN-13(EAN): 9780792326786
Издательство: Springer
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Цена: 56042.00 р.
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Genomic Instability and Cancer Metastasis

Автор: Chris Maxwell; Cal Roskelley
Название: Genomic Instability and Cancer Metastasis
ISBN: 3319352954 ISBN-13(EAN): 9783319352954
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse.

Chromosomal Instability in Cancer Cells

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319349627 ISBN-13(EAN): 9783319349626
Издательство: Springer
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Цена: 11179.00 р.
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer.

Trinucleotide Repeat Protocols

Автор: Yoshinori Kohwi; Cynthia T. McMurray
Название: Trinucleotide Repeat Protocols
ISBN: 1627034102 ISBN-13(EAN): 9781627034104
Издательство: Springer
Рейтинг:
Цена: 15372.00 р.
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Описание: Coverage in this volume includes an overview of trinucleotide repeat diseases, synaptic plasticity, embryonic stem (ES) cell-related protocols with a focus on HD, RNA-related protocols, and analysis of epigenetic modification in fragile X syndrome.

Genome Instability

Автор: Marco Muzi-Falconi; Grant W Brown
Название: Genome Instability
ISBN: 1493973053 ISBN-13(EAN): 9781493973057
Издательство: Springer
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Цена: 22359.00 р.
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Описание:

1. The A-like Faker Assay for Measuring Yeast Chromosome III Stability

Carolina A. Novoa, J. Sidney Ang, and Peter C. Stirling

2. The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast

Supipi Duffy and Philip Hieter

3. Measuring Mutation Rates using the Luria-Delbrьck Fluctuation Assay

Gregory I. Lang

4. Molecular Genetic Characterization of Mutagenesis Using a Highly Sensitized Single-Stranded DNA Reporter System in Budding Yeast

Kin Chan

5. Analyzing Genome Rearrangements in Saccharomyces cerevisiae

Anjana Srivatsan, Christopher D. Putnam, and Richard D. Kolodner

6. High Resolution Mapping of Modified DNA Nucleobases using Excision Repair Enzymes

Monica Ransom, D. Suzi Bryan and Jay R. Hesselberth

7. Integrated Microarray-based Tools for Detection of Genomic DNA Damage and Repair Mechanisms

Patrick van Eijk, Yumin Teng, Mark R. Bennet, Katie E. Evans, James R. Powell, Richard M. Webster, and Simon H. Reed

8. Study of UV-induced DNA Repair Factor Recruitment: Kinetics and Dynamics

Sertic S., Roma S., Plevani P., Lazzaro F., and Muzi-Falconi M.

9. Inserting Site-specific DNA Lesions into Whole Genomes

Vincent Pagиs and Robert P Fuchs

10. A qPCR-based Protocol to Quantify DSB Resection

Matteo Ferrari, Shyam Twayana, Federica Marini, and Achille Pellicioli

11. Alkaline Denaturing Southern Blot Analysis to Monitor Double-strand Break Processing

Chiara Vittoria Colombo, Luca Menin, and Michela Clerici

12. Single Molecule Analysis of Resection Tracks

Pablo Huertas and Andrйs Cruz-Garcнa

13. Mapping DNA Breaks by Next-generation Sequencing

Laura Baranello, Fedor Kouzine, Damian Wojtowicz, Kairong Cui, Keji Zhao, Teresa M Przytycka, Giovanni Capranico, and David Levens

14. Genome-wide Profiling of DNA Double-strand Breaks by the BLESS and BLISS Methods

Reza Mirzazadeh, Tomasz Kallas, Magda Bienko, and Nicola Crosetto

15. DNA Replication Profiling using Deep Sequencing

Xanita Saayman, Cristina Ramos-Pйrez, and Grant W Brown

16. Quantitative Bromodeoxyuridine Immunoprecipitation Analyzed by High-Throughput Sequencing (qBrdU-seq or QBU)

Joanna E. Haye-Bertolozzi and Oscar M. Aparicio

17. Strand-specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast

Chuanhe Yu, Haiyun Gan, and Zhiguo Zhang

18. Analysis of Replicative Polymerase Usage by Ribonucleotide Incorporation

Andrea Keszthelyi, Izumi Miyabe, Katie Ptasińska, Yasukazu Daigaku, Karel Naiman, and Antony M. Carr

19. Dynamic Architecture of Eukaryotic DNA Replication Forks in vivo, Visualized by Electron Microscopy

Ralph Zellweger and Massimo Lopes

20. A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation

Nicolai B. Larsen, Ian D. Hickson, and Hocine W. Mankouri

21. Single Cell Gel Electrophoresis for the Detection of Genomic Ribonucleotides

Barbara Kind, Christine Wolf, Kerstin Engel, Alexander Rapp, M. Cristina Cardoso, and Min Ae Lee-Kirsch

22. Measuring the Levels of Ribonucleotides Embedded in Genomic DNA

Meroni A., Nava G.M., Sertic S., Plevani P., Muzi-Falconi M. and Lazzaro F.

23. Mapping Ribonucleotides Incorporated into DNA by Hydrolytic End-Sequencing

Clinton D. Orebaugh, Scott A. Lujan, Adam B. Burkholder, Anders R Clausen, and Thomas A. Kunkel

Genetic Instability and Tumorigenesis

Автор: Michael B. Kastan
Название: Genetic Instability and Tumorigenesis
ISBN: 3642644341 ISBN-13(EAN): 9783642644344
Издательство: Springer
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Цена: 18167.00 р.
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Описание: KASTAN Cancer is a disease resulting from alterations of cellular genes which cause phe- notypic changes in somatic cells. The vast majority of genes which are altered in the cancer cells are not transmitted through the germ line, but rather become abnormal in somatic cells sometime during the lifetime of the individual.

Genomic Instability and Immortality in Cancer

Автор: Enrico Mihich; Leland Hartwell
Название: Genomic Instability and Immortality in Cancer
ISBN: 1461374480 ISBN-13(EAN): 9781461374480
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Proceedings of the Eighth Annual Pezcoller Symposium held in Trento, Italy, June 17-19, 1996


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