Описание: Hamed Alborzinia uses the biosensor chip to monitor the metabolic and morphological changes in cancer cell lines in real time, particularly: (i) real-time measurements of basic cancer cell metabolism of different cancer cell lines;
Автор: K.W. Bock; Frederick C. Kauffman; B. Burchell; M. Название: Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity ISBN: 3642784313 ISBN-13(EAN): 9783642784316 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology.
Автор: Hawksworth, Gabrielle M. Название: Current Concepts In Drug Metabolism And Toxicology,63 ISBN: 0123983398 ISBN-13(EAN): 9780123983398 Издательство: Elsevier Science Рейтинг: Цена: 29812.00 р. Наличие на складе: Нет в наличии.
Описание: Suitable for Pharmacologists, Immunologists and Biochemists alike, this title explores the concepts in drug metabolism and toxicology.
Описание: In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization.
Описание: Drug Metabolism in Drug Design and Development provides a practical description of what happens during the drug design and development process and focuses on issues such as: what data are needed; what experiments and analytical methods are typically employed; and how to interpret and apply data.
Автор: G. Gordon Gibson; Paul Skett Название: Introduction to Drug Metabolism ISBN: 0412263904 ISBN-13(EAN): 9780412263903 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Although the scientific literature on drug metabolism is extensive, it suffers from the disadvantage that the material is diffuse and consists largely of specialist monographs dealing with particular aspects of the subject.
Автор: Nagar Название: Enzyme Kinetics in Drug Metabolism ISBN: 1071615564 ISBN-13(EAN): 9781071615560 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This second edition further develops the principles of applying kinetic principles to drug metabolizing enzymes and transporters. Chapters are divided into six sections detailing fundamental principles of enzyme kinetics, enzyme and transporter structures, highlighting specific oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for drug metabolizing enzymes and transporters, understanding of variability both experimental and interindividual (pharmacogenomic), and expanded case studies that provide real life examples of applying these principles. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, in some cases step-by-step instructions with readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and fully updated, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications, Second Edition serves as a practical teaching tool for novice and advanced scientists interested in the fundamental concepts.
Автор: Carlat Daniel J. Название: Drug Metabolism in Psychiatry: A Clinical Guide ISBN: 0692357882 ISBN-13(EAN): 9780692357880 Издательство: Неизвестно Цена: 6890.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Nagar Swati, Argikar Upendra A., Tweedie Donald Название: Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications ISBN: 107161553X ISBN-13(EAN): 9781071615539 Издательство: Springer Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed book aims to provide an overview of novel bioinformatics resources for exploring diverse aspects of RNA biology. This edition focuses on methods dealing with non-coding RNA (miRNAs, circRNAs or lncRNAs), RNA modifications (m6A or RNA editing), single cell RNA-seq and statistical models to handle count data from RNA-seq experiments.
Название: Handbook of Drug Metabolism ISBN: 0367399857 ISBN-13(EAN): 9780367399856 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject in a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.
Описание: This multi-volume, state-of-the-art encyclopedia discusses all preclinical, clinical, toxicological, regulatory and marketing perspectives of drug metabolism and interactions. Methods and detailed protocols describing how to perform studies of metabolism and drug interactions are presented in one of the volumes.
Автор: Aparajita Dey Название: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism ISBN: 9400758804 ISBN-13(EAN): 9789400758803 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The book examines clinical aspects of cytochrome P450 2E1(CYP2E1), covering clinical disorders associated with changes in the regulation of CYP2E1 and consequent abnormalities including alcoholic liver disease, hepatitis C, inhibition of bone repair and more.
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