How We Age : The Science of Longevity, Murphy, Coleen T.

Автор: Lopez-Otin, Carlos
Название: Mitochondria and Longevity
ISBN: 0128157364 ISBN-13(EAN): 9780128157367
Издательство: Elsevier Science
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Цена: 27791.00 р.
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Описание: Mitochondria and Longevity, Volume 340, the latest release in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics with this release focusing on topics such as Mitochondria metabolism and aging, Mitohormesis, Mitochondrial dynamics in the aging stem cell compartment, Mitochondrial proteostasis and aging, Mitochondrial DNA mutations and aging, Mitochondrial sirtuins, NAD+, NADH and aging, Mitophagy and aging, Mitochondria, calcium transport and aging.

Автор: Suresh Rattan; Ramesh Sharma
Название: Hormones in Ageing and Longevity
ISBN: 3319874500 ISBN-13(EAN): 9783319874500
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This multi-chapter book focuses on one of the hottest topics in ageing research - the role of hormones in health and longevity, offering a comprehensive and up-to-date overview of their mechanistic roles in health, ageing and longevity.

Автор: Moskalev, Alexey
Название: Epigenetics of Aging and Longevity
ISBN: 0128110600 ISBN-13(EAN): 9780128110607
Издательство: Elsevier Science
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Цена: 19875.00 р.
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Описание:

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses--including cancer and cardiovascular, metabolic, and neurodegenerative diseases--are explored in detail.

Автор: Marco Malavolta; Eugenio Mocchegiani
Название: Trace Elements and Minerals in Health and Longevity
ISBN: 303003741X ISBN-13(EAN): 9783030037413
Издательство: Springer
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Цена: 22359.00 р.
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Описание: This book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, ande) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.

Автор: Mori
Название: Aging Mechanisms II
ISBN: 9811679797 ISBN-13(EAN): 9789811679797
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book describes the recent advancement of basic research on the biology of aging and longevity studies in various organisms, as well as the neurobiology of aging and neurodegeneration mechanisms. Chapters present new findings and conceptual developments concerning the basic mechanisms of aging and longevity determination. As a follow-up volume to the previous book Aging Mechanisms (2015), it overviews the rapid progress of aging research introducing new topics from leading laboratories in Japan. Chapter contributors are selected based on recent scientific achievements on the mechanisms of aging in various model organisms, including yeast, worm (C. elegans), fly (Drosophila), mice, and rats. Chapters are ordered from the discussion on molecular and cellular levels to physiological and systemic levels. The book also provides an overview of aging science in the region and helps readers quickly grasp who is doing what in this research area. As the aging of population becomes an ever more pressing issue in Asia, advancing the understanding of basic mechanisms of organism aging and longevity determination will be crucial to developing more effective therapies and protective strategies. Researchers and graduate students in biomedical aging research will find this as a rich source of information and a stimulus to novel research directions.

Автор: Anders Olsen; Matthew S. Gill
Название: Ageing: Lessons from C. elegans
ISBN: 3319447017 ISBN-13(EAN): 9783319447018
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans. With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.

Автор: Gil Atzmon, PhD
Название: Longevity Genes
ISBN: 1493924036 ISBN-13(EAN): 9781493924035
Издательство: Springer
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Цена: 19564.00 р.
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Описание: The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

Автор: Arthur V. Everitt; Suresh I. S. Rattan; David G. C
Название: Calorie Restriction, Aging and Longevity
ISBN: 9400791151 ISBN-13(EAN): 9789400791152
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Long-term reduction in calorie intake will delay the onset of age-related diseases such as heart disease, diabetes and cancer. This book provides the latest information on the beneficial effects of calorie restriction on health and life-span.

Автор: Arking, Robert (professor Of Biological Sciences, Professor Of Biological Sciences, Wayne State University)
Название: Biology of longevity and aging
ISBN: 0199387966 ISBN-13(EAN): 9780199387960
Издательство: Oxford Academ
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Цена: 14573.00 р.
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Описание: The world is facing an energy crisis. As the finite supply of fossil fuels such as coal, gas and oil upon which we depend dwindle - indeed, some scientists predict that oil could run out within the next 45 years - humanity must look to renewable sources of energy to generate power. But how efficient and sustainable are alternative energy sources such as wind, wave and solar power? And is it safe to continue using nuclear power? Can we as individuals make a difference? This book looks at our current use of energy and at what the future is likely to hold. The information comes from a variety of sources, including government reports and statistics, newspapers and magazine articles, surveys and polls, academic research and literature from charities and lobby groups; articles have been tailored to an 11 to 14 age group. Additionally, at the end of each chapter are two pages of activities relating to the articles and issues raised in that chapter.

Автор: Jagota
Название: Sleep and Clocks in Aging and Longevity
ISBN: 3031224671 ISBN-13(EAN): 9783031224676
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This edited volume focuses on the interplay between sleep and circadian rhythms with health, aging and longevity. Sleep is absolutely important for human health and survival, as insufficient sleep is associated with a plethora of conditions, including the poor quality of life, onset of several diseases, and premature death. The sleep–wake cycle is an evolutionary conserved neurobiological phenomenon, and is a prominent manifestation of the biological clocks localised in the suprachiasmatic nucleus (SCN). Understanding bidirectional relationship between sleep and circadian rhythms is of utmost importance and urgency, especially in the context of modern lifestyle where sleep is often out of phase with the internal body clocks, social jetlag, artificial lights and so on. The 25 chapters by leading researchers and experts from 11 countries are arranged into seven sections: understanding sleep and clock interlink in health and longevity; sleep, aging and longevity; clock, aging and longevity; melatonin, sleep and clock; genetic regulation of sleep and clock; therapeutic interventions in sleep disorders and clock misalignment; and experimental models to study sleep and clocks in aging and longevity. This book is useful for advanced undergraduate and graduate students, and researchers, educators, and other biomedical professionals.

Автор: Byung Pal Yu
Название: Nutrition, Exercise and Epigenetics: Ageing Interventions
ISBN: 331914829X ISBN-13(EAN): 9783319148298
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.

Автор: Muсoz-Espin Daniel, DeMaria Marco
Название: Senolytics in Disease, Ageing and Longevity
ISBN: 303044905X ISBN-13(EAN): 9783030449056
Издательство: Springer
Цена: 19564.00 р.
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Описание: This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing.