Magnetic Resonance and its Applications in Drug Formulation and Delivery 9781788017404

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Автор: Leslie P Hughes, Michael D Mantle
Название: Magnetic Resonance and its Applications in Drug Formulation and Delivery
ISBN: 9781788017404
Издательство: Royal Society of Chemistry
Классификация:

Магнитный резонанс

Технологии производства фармацевтических препаратов

ISBN-10: 1788017404
Обложка/Формат: Hardback
Страницы: 415
Вес: 0.79 кг.
Дата издания: 10.04.2024
Серия: New developments in nmr
Язык: English
Размер: 234 x 156
Ключевые слова: Magnetic resonance,Pharmaceutical technology, SCIENCE / Chemistry / Analytic,TECHNOLOGY & ENGINEERING / Biomedical,TECHNOLOGY & ENGINEERING / Chemical & Biochemical
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Поставляется из: Англии
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This book details the latest research and development in the use of magnetic resonance imaging and spectroscopy as tools to give quantitative insights concerning late stage pharmaceutical formulation, tablet manufacturing and drug dissolution behaviour. The book combines different facets of magnetic resonance and highlights the use of spatial resolution (MRI) and how this adds to the knowledge base to further our understanding of the microscopic physicochemical processes occurring during drug release from solid dosage forms.
New topics, that have not been thoroughly reviewed elsewhere, are covered including the applications of solution state magnetic resonance in process scale up, reaction monitoring/understanding and process analytical technologies (PAT); dissolution testing; and counterfeit analysis. Solid state NMR and its role in understanding phase separation in dispersions, polymorphism and crystallography is included and magnetic resonance imaging and its use in assessing tablet dissolution performance, mass transport and mixing in hot melt extrusion (HME) are covered.
Focusing on late stage development rather than molecular drug discovery provides a unique approach and the book will appeal to a diversity of disciplines using spectroscopy for study. Aimed at researchers in drug development, manufacture and formulation in both industry (pharmaceutical companies) and academia (pharmacy program), it includes examples, where appropriate, of studies on commercially available pharmaceutical products.

Magnetic Resonance and its Applications in Drug Formulation and Delivery, Leslie P Hughes, Michael D Mantle