Neuropsychiatric Disorders And Epigenetics, Peedicayil,Jacob
Старое издание
Автор: Yasui, Dag Название: Neuropsychiatric Disorders and Epigenetics ISBN: 0128002263 ISBN-13(EAN): 9780128002261 Издательство: Elsevier Science Цена: 13980.00 р. Наличие на складе: Есть у поставщикаПоставка под заказ. Описание:
Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.
Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.
Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment
Автор: Johannes Backs, Timothy McKinsey Название: Epigenetics in Cardiac Disease ISBN: 3319414550 ISBN-13(EAN): 9783319414553 Издательство: Springer Рейтинг: Цена: 14673.00 р. 20962.00-30% Наличие на складе: Есть (1 шт.) Описание: This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.
Автор: Naumova Anna K & Taketo-Hosotani Teruko Название: Epigenetics In Human Reproduction And Development ISBN: 9813144262 ISBN-13(EAN): 9789813144262 Издательство: World Scientific Publishing Цена: 18216.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Epigenetics is defined as heritable changes that do not affect the DNA sequence but influence gene expression. Epigenetic changes occur at the levels of DNA, histone, protein, and chromatin structures. Proper epigenetic modifications are essential for cell differentiation and function during development, while some epigenetic modifications are passed on from parents to offspring through gametes. Therefore, alterations of epigenetic states would have serious consequences for human development and health. This realization and the advent of new technologies have encouraged the advance of epigenetic studies in recent years. Nonetheless, many aspects of epigenetics, such as regulatory mechanisms and evolutional advantages, remain to be better understood.
Written by 26 scientists at the forefront of epigenetics research, this book discusses the different facets of epigenetics: from gametogenesis to child development, as well as from mechanistic studies in animal models to reviews of human clinical data.
Описание: This book explores mental disorders from a uniquely evolutionary perspective.
Автор: Guest Paul C. Название: Proteomic Methods in Neuropsychiatric Research ISBN: 3319849115 ISBN-13(EAN): 9783319849119 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Due to continuous technical developments and new insights into the high complexity of neurological diseases, there is an increasing need for the application of proteomic technologies which can yield potential biomarker readouts for improved clinical management as well as for the development of new drugs by struggling pharmaceutical companies.
Автор: Yasui, Dag Название: Neuropsychiatric Disorders and Epigenetics ISBN: 0128002263 ISBN-13(EAN): 9780128002261 Издательство: Elsevier Science Рейтинг: Цена: 13980.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease.
Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development.
Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction
Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists
Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment
Автор: Gupta Название: Sleep and Neuropsychiatric Disorders ISBN: 9811601259 ISBN-13(EAN): 9789811601255 Издательство: Springer Рейтинг: Цена: 32142.00 р. Наличие на складе: Поставка под заказ.
Описание: This book explores the intricate links between sleep and neuropsychiatric diseases. In clinical settings, understanding the development, treatment, and management of neuropsychiatric diseases poses a substantial challenge. Neuropsychiatric disorders place a significant cost on society, affecting the health of people affected, care providers, and the general community. Sleep and neuropsychiatric disease are inextricably linked. Sleep disorders are widespread in these populations and are frequently overlooked in neurology and psychiatry. The book offers readers up-to-date information on different facets of the bidirectional connections between sleep and neuropsychiatric diseases. Following the initial fundamental science part, a unique series of chapters concentrate on the behavioural manifestations of sleep problems, a hitherto unexplored field. Additional chapters include patient evaluation techniques as well as public health implications of sleep disorders. The individual chapters cover all main mental and neurological diseases where a change in sleep is evident, and recent concepts in pathogenesis, presentation, evaluation, and treatment. Neuropsychotropic drugs must be seen as a double-edged sword when it comes to sleep and sleep disorders. Overall, this book is an excellent resource for learning about neuropsychiatric diseases and how they affect sleep while simultaneously being impacted by sleep.
Описание: This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
Описание: This book provides an up-to-date overview of the role of neurosteroids and neuroactive steroids in the regulation of brain processes and neuropsychiatric disorders. It addresses the neurosteroid function in brain development and plasticity, in both the normal and the pathological brain.
Автор: Pavlovic Название: Glutamate and Neuropsychiatric Disorders ISBN: 3030874826 ISBN-13(EAN): 9783030874827 Издательство: Springer Рейтинг: Цена: 32142.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a comprehensive overview of recent advances in targeting glutamate signaling for the treatment of major psychiatric and neurological disorders. It draws on the latest findings in glutamate neurobiology and offers valuable insights into the application of translational principles in neuroscience drug discovery and development. In each chapter, glutamate as a neurotransmitter, its receptors and transporters, and their interplay with other neurotransmitters and neurotrophic factors, are discussed in the context of a specific, highly prevalent and disabling CNS disease. Most recent and detailed information is provided on Ischemic Stroke, Chronic Stress, Major Depressive Disorder, Bipolar Disorder, Autism Spectrum Disorders (ASD), Posttraumatic Stress Disorder (PTSD), Alzheimer’s Dementia, Schizophrenia, Impulsive Aggression, Substance Use Disorders (SUD), Amyotrophic Lateral Sclerosis (ALS), Chronic Pain, Multiple Sclerosis, Parkinson’s Disease, Attention Deficit Hyperactivity Disorder (ADHD), Migraine, Epilepsy and Anxiety disorders. Moreover, the book includes an extensive overview of glutamatergic treatments already available on the market, and those which are currently in pharmaceutical drug development pipelines. The primary beneficiaries will be neurology and psychiatry specialists and residents, neuroscientists, neuropharmacologists, pharmaceutical industry and clinical research organization professionals, academics, and clinicians working with psychiatric and neurological patients with comorbidities such as cardiologists, pulmonologists, and endocrinologists. This book will also appeal to psychiatry and neurology subspecialists and clinicians working in neuroscience labs seeking an easy-to-understand yet comprehensive overview of contemporary evidence-based clinical insights backed by basic science (preclinical) research evidence. Given its scope, the book is also a unique and indispensable resource for both preclinical and clinical neuroscientists, medical advisors, and clinical research specialists in the pharmaceutical industry. In addition, it will appeal to neuroscience and neuropsychopharmacology students and guide them through the complexities of glutamate involvement in the pathophysiology of the most common debilitating brain diseases with high unmet medical needs.
Автор: Granacher, Jr. Название: Traumatic Brain Injury ISBN: 1466594802 ISBN-13(EAN): 9781466594807 Издательство: Taylor&Francis Рейтинг: Цена: 26796.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Traumatic Brain Injury: Methods for Clinical and Forensic Neuropsychiatric Assessment, Third Edition provides physicians and psychologists with a scientifically based schema for the clinical evaluation of traumatic brain injury (TBI).
The book assists physicians and psychologists in developing treatment plans for patients who have sustained TBIs and also guides those providing forensic analysis to lawyers, insurance bodies, workers' compensation systems, triers of fact, and other stakeholders in the adjudication of victims of TBI.
The procedures and recommendations in this book are grounded in highly referenced evidence-based science but also come from more than 5000 cases wherein the author and contributors have personally examined individuals who have sustained a TBI, or who claim to have sustained a TBI.
This edition has been entirely rewritten. The style now follows a more traditional neuropsychiatric format than previous editions. Since the last edition, there has been increased awareness and scientific study regarding the effects of blast brain injury as a consequence of US military experiences in Afghanistan and Iraq.
There is also increased interest in the phenomenology of mild traumatic brain injury and, in particular, the forensic complications associated with evaluations of this disorder. Chronic traumatic encephalopathy has also received significant scrutiny in the last decade, possibly associated with sports injuries.
This book is a comprehensive resource for clinicians treating patients as well as for forensic specialists. Its purpose remains the same as in prior editions--to provide physicians or psychologists with a practical method for an effective evaluation of TBI based upon known scientific principles of brain-behavior relationships and state-of-the-art clinical, neuroimaging, neuropsychological, and psychological techniques.
Автор: Francis Richard C. Название: Epigenetics: How Environment Shapes Our Genes ISBN: 039334228X ISBN-13(EAN): 9780393342284 Издательство: Wiley Рейтинг: Цена: 2058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Goodbye, genetic blueprint. . . . The first book for general readers on the game-changing field of epigenetics.
Автор: Moskalev, Alexey Название: Epigenetics of Aging and Longevity ISBN: 0128110600 ISBN-13(EAN): 9780128110607 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Описание:
Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses--including cancer and cardiovascular, metabolic, and neurodegenerative diseases--are explored in detail.
This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
