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Integrative Omics in Parkinson`s Disease, Edited by Joanne Trinh, PhD, Institute of Neurogen


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Автор: Edited by Joanne Trinh, PhD, Institute of Neurogen
Название:  Integrative Omics in Parkinson`s Disease
ISBN: 9780443135507
Издательство: Elsevier Science
Классификация:

ISBN-10: 0443135509
Обложка/Формат: Paperback
Страницы: 274
Вес: 0.45 кг.
Дата издания: 24.09.2024
Размер: 229 x 152
Ссылка на Издательство: Link
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Поставляется из: Европейский союз
Описание: Integrative Omics in Parkinson’s Disease provides a comprehensive understanding of the current literature on high-throughput technologies relating to discoveries for Parkinsons disease etiology. This emerging field uses large omics datasets to investigate the etiology of Parkinson’s disease and other forms of parkinsonism. The book traces the evolution of omics technologies from the discovery of monogenic Parkinsons disease forms. Chapters delve into genomics, transcriptomics, epigenomics, artificial intelligence, and gene-environment interactions. Furthermore, it examines the potential therapeutic applications of these advancements and provides insights into the future of omics research in Parkinsons disease.
Дополнительное описание: Reviews evolution of omics technologies from the first identification of monogenic forms of Parkinson’s diseaseOutlines machine learning algorithm application to Parkinson’s disease datasetsReviews big datasets on gene-environment interactions, genomics,



Sexual Dysfunction in Parkinson`s Disease: Volume 162

Название: Sexual Dysfunction in Parkinson`s Disease: Volume 162
ISBN: 012821175X ISBN-13(EAN): 9780128211755
Издательство: Elsevier Science
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Цена: 27791.00 р.
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Описание: Sexual Dysfunction in Parkinson's Disease, Volume 182, the latest release in the International Review of Neurobiology series, highlights new advances in the field with this new volume presenting interesting chapters on a variety of trending and important topics, including Prevalence, clinical presentations and impact on relationship, Pathophysiology, Scales for assessing sexual dysfunction in Parkinson's disease, Diagnostic work up: Laboratory and biomarkers, Management strategies, ICD DDS and sex dysfunction, Non-motor fluctuations and sex dysfunction, Exploring Sexual Dysfunction in Care Homes, and The impact of non-motor symptoms burden on sexual functions.

The Neuroscience Of Parkinson`S Disease

Автор: Martin, Colin R.
Название: The Neuroscience Of Parkinson`S Disease
ISBN: 0128159588 ISBN-13(EAN): 9780128159583
Издательство: Elsevier Science
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Цена: 45477.00 р.
Наличие на складе: Нет в наличии.

Описание: Collins Big Cat Phonics for Letters and Sounds features exciting fiction and non-fiction decodable readers to enthuse and inspire children. They are fully aligned to Letters and Sounds Phases 1-6 and contain notes in the back. The Handbooks provide support in demonstration and modelling, monitoring comprehension and expanding vocabulary.

Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson`s Disease

Автор: Gruschus James M.
Название: Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson`s Disease
ISBN: 0323857078 ISBN-13(EAN): 9780323857079
Издательство: Elsevier Science
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Цена: 19370.00 р.
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Описание:

Most neurodegenerative diseases have animal parallels such as Alzheimer's in chimpanzees, multiple sclerosis in macaques, Lou Gehrig's disease in dogs, but nothing like Parkinson's has ever been seen in any species but humans. Synuclein and the Coelacanth: The Molecular and Evolutionary Origins of Parkinson's Disease delves into the causes of Parkinson's disease and how the evolution of the human brain has left us uniquely vulnerable. Genetic risk factors, environmental toxins, and neuroanatomy are woven together in a multidisciplinary discussion that ranges from subatomic physics to socioeconomics. Connections between neurodegenerative disease, neural pathways, and innate immunity are explored. Finally, the author discusses new therapeutic agents are being developed that hope to go beyond just treating the symptoms of Parkinson's and actually halt the disease.

Neuroimaging In Parkinson`S Disease And Related Disorders

Автор: Politis, Marios
Название: Neuroimaging In Parkinson`S Disease And Related Disorders
ISBN: 0128216514 ISBN-13(EAN): 9780128216514
Издательство: Elsevier Science
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Цена: 26107.00 р.
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Описание: My experience as a State Correction Officer inside New Yorks Prisons. As you read Paul Harringtons day-to-day and month-to-month experiences within the states prison system, you will see a broken system one that is full of loopholes, lies, cover-ups and corruption. This system is full of daily violence and numerous officers are injured by violent inmates. Each officer has their unique view of the prison system. Here, Harrington wishes to share his perspective of how different administrations created changes in the daily operations at Fishkill Correctional Facility, where he was stationed after a 15-month stint at Sing Sing. Not every day was

Restorative Therapies in Parkinson`s Disease

Автор: Patrik Brundin; C. Warren Olanow
Название: Restorative Therapies in Parkinson`s Disease
ISBN: 1489995226 ISBN-13(EAN): 9781489995223
Издательство: Springer
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Цена: 22359.00 р.
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Описание: Never in history has there been greater hope that novel experimental therapies can support significant restoration of brain function. The field of restorative therapies in Parkinson’s disease has passed the initial phase of pioneering experimental and clinical trials. There still does not exist restorative therapy that can be applied in large numbers of patients, but the initial trials have provided us with fundamental insight into the potential for plasticity in the diseased brain. This book gives an overview of the current state-of-the-art research for brain repair, what the challenges are and an indication of what research can provide for the next generation of people with Parkinson’s disease.

Parkinson`s: A Glimpse Into the Disease. 2nd Edition

Автор: Keller Steven P.
Название: Parkinson`s: A Glimpse Into the Disease. 2nd Edition
ISBN: 1087944244 ISBN-13(EAN): 9781087944241
Издательство: Неизвестно
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Цена: 2757.00 р.
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Описание:

Hidden Truths discusses nearly every aspect of Parkinson`s disease. It provides answers to unexplained questions and concerns. This is a useful guide for patients, caregivers and medical personnel providing insight on coping with the disease.

Parkinson`s disease

Название: Parkinson`s disease
ISBN: 0367389150 ISBN-13(EAN): 9780367389154
Издательство: Taylor&Francis
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Цена: 9492.00 р.
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Описание:

An authoritative collection of recent breakthroughs in Parkinson's Disease (PD) research, Parkinson's Disease: Genetics and Pathogenesis spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead to improved therapies for PD. The book reviews the major aspects of the disease including motoric and pathologic features, autonomic dysfunction, sleep disorders, and neuropsychiatric manifestations. It also provides an in-depth review of genetic considerations. With contributions by recognized experts on the topic, emphasis is placed on pathogenesis, experimental models, future therapeutic opportunities, and research trends affecting the field.

Mitochondrial Mechanisms of Degeneration and Repair in Parkinson`s Disease

Автор: Buhlman
Название: Mitochondrial Mechanisms of Degeneration and Repair in Parkinson`s Disease
ISBN: 3319421379 ISBN-13(EAN): 9783319421377
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This volume brings together various theories of how aberrations in mitochondrial function and morphology contribute to neurodegeneration in idiopathic and familial forms of Parkinson’s disease. Moreover, it comprehensively reviews the current search for therapies, and proposes how molecules are involved in specific functions as attractive therapeutic targets. It is expected to facilitate critical thought and discussion about the fundamental aspects of neurodegeneration in Parkinson’s disease and foster the development of therapeutic strategies among researchers and graduate students. Theories of idiopathic Parkinson’s etiology support roles for chronic inflammation and exposure to heavy metals or pesticides. Interestingly, as this project proposes, a case can be made that abnormalities in mitochondrial morphology and function are at the core of each of these theories. In fact, the most common approach to the generation of animal and cell-culture models of idiopathic Parkinson’s disease involves exposure to mitochondrial toxins. Even more compelling is the fact that most familial patients harbor genetic mutations that cause disruptions in normal mitochondrial morphology and function. While there remains to be no effective treatment for Parkinson’s disease, efforts to postpone, prevent and “cure” onset mitochondrial aberrations and neurodegeneration associated with Parkinson’s disease in various models are encouraging. While only about ten percent of Parkinson’s patients inherit disease-causing mutations, discovering common mechanisms by which familial forms of Parkinson’s disease manifest will likely shed light on the pathophysiology of the more common idiopathic form and provide insight to the general process of neurodegeneration, thus revealing therapeutic targets that will become more and more accessible as technology improves.

Nonlinear Dynamics Of Parkinson`S Disease And The Basal Ganglia-Thalamic-Cortical System

Автор: Montgomery Jr.,Erwin B.
Название: Nonlinear Dynamics Of Parkinson`S Disease And The Basal Ganglia-Thalamic-Cortical System
ISBN: 0443216991 ISBN-13(EAN): 9780443216992
Издательство: Elsevier Science
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Цена: 27791.00 р.
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Experimental Models of Parkinson`s Disease

Автор: Imai Yuzuru
Название: Experimental Models of Parkinson`s Disease
ISBN: 1071614940 ISBN-13(EAN): 9781071614945
Издательство: Springer
Цена: 18167.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Part I: Biochemical Experiments and Cellular Models of Parkinson's Disease

1. α-Synuclein Seeding Assay Using RT-QuIC

Ayami Okuzumi, Taku Hatano, Takeshi Fukuhara, Shinichi Ueno, Nobuyuki Nukina, Yuzuru Imai, and Nobutaka Hattori

2. Electron-Microscopic Analysis of α-Synuclein Fibrils

Airi Tarutani and Masato Hasegawa

3. α-Synuclein Seeding Assay Using Cultured Cells

Jun Ogata, Daisaku Takemoto, Shotaro Shimonaka, Yuzuru Imai, and Nobutaka Hattori

4. Analysis of α-Synuclein in Exosomes

Taiji Tsunemi, Yuta Ishiguro, Asako Yoroisaka, and Nobutaka Hattori

5. Measurement of GCase Activity in Cultured Cells

Yuri Shojima, Jun Ogata, Taiji Tsunemi, Yuzuru Imai, and Nobutaka Hattori

6. Detection of Substrate Phosphorylation of LRRK2 in Tissues and Cultured Cells

Kyohei Ito, Lejia Xu, Genta Ito, and Taisuke Tomita

7. Two Methods to Analyze LRRK2 Functions Under Lysosomal Stress: The Measurements of Cathepsin Release and Lysosomal Enlargement

Maria Sakurai and Tomoki Kuwahara

8. Differentiation of Midbrain Dopaminergic Neurons from Human iPS Cells

Kei-ichi Ishikawa, Risa Nonaka, and Wado Akamatsu

9. Monitoring PINK1-Parkin Signaling Using Dopaminergic Neurons from iPS Cells

Kahori Shiba-Fukushima and Yuzuru Imai

Part II: Mammalian Models of Parkinson's Disease

10. Generation of Mitochondrial Toxin Rodent Models of Parkinson's Disease Using 6-OHDA, MPTP, and Rotenone

Hiroharu Maegawa and Hitoshi Niwa

11. Midbrain Slice Culture as an Ex Vivo Analysis Platform for Parkinson's Disease

Yuji Kamikubo, Keiko Wakisaka, Yuzuru Imai, and Takashi Sakurai

12. α-Synuclein Propagation Mouse Models of Parkinson's Disease

Norihito Uemura, Jun Ueda, Shinya Okuda, Masanori Sawamura, and Ryosuke Takahashi

13. Common Marmoset Model of α-Synuclein Propagation

Masami Masuda-Suzukake, Aki Shimozawa, Masashi Hashimoto, and Masato Hasegawa

14. Application of a Tissue Clearing Method for the Analysis of Dopaminergic Axonal Projections

Kenta Yamauchi, Megumu Takahashi, and Hiroyuki Hioki

15. Deep Brain Stimulation Using Animal Models of Parkinson's Disease

Asuka Nakajima and Yasushi Shimo

Part III: Invertebrate Models of Parkinson's Disease

16. Assessment of Cytotoxicity of α-Synuclein in Budding Yeast Using a Spot Growth Assay and Fluorescent Microscopy

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Clinical Trials In Parkinson`s Disease

Автор: Santiago Perez-Lloret
Название: Clinical Trials In Parkinson`s Disease
ISBN: 1071609114 ISBN-13(EAN): 9781071609118
Издательство: Springer
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Цена: 15372.00 р.
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Описание: This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson`s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection.

The Molecular and Cellular Basis for Parkinson`s Disease

Название: The Molecular and Cellular Basis for Parkinson`s Disease
ISBN: 3039215485 ISBN-13(EAN): 9783039215485
Издательство: Неизвестно
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Цена: 9402.00 р.
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