Connections, Cognition and Alzheimer`s Disease, Bradley T. Hyman; Charles Duyckaerts
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 17149.00 р. 24499.00-30% Наличие на складе: Есть (1 шт.) Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Автор: Bradley T. Hyman; Jean-Francois Demonet Название: The Living Brain and Alzheimer`s Disease ISBN: 3642639275 ISBN-13(EAN): 9783642639272 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer`s Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas.
Автор: Yoshikuni Mizuno; Abraham Fisher; Israel Hanin Название: Mapping the Progress of Alzheimer`s and Parkinson`s Disease ISBN: 1475709730 ISBN-13(EAN): 9781475709735 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 1h The 5 International Conference on the Progress in Alzheimer`s Disease and Parkinson`s 51 1 Disease took place from March 31 to April 5 \ 2001 in Kroto, Japan. This international 1 conference was organized as a joint Congress with the 9 International Catecholamine Symposium.
Автор: Budson Название: The Handbook of Alzheimer`s Disease and Other Dementias ISBN: 1118672852 ISBN-13(EAN): 9781118672853 Издательство: Wiley Рейтинг: Цена: 4744.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is a broad-ranging review of the current research on Alzheimer`s disease and other dementias from both basic neuroscience and clinical perspectives. It provides scientists and medical professionals with an extensive introduction and an up-to-date review of cutting-edge scientific advances in a single volume.
Автор: Mathias Jucker; Konrad Beyreuther; Christian Haass Название: Alzheimer: 100 Years and Beyond ISBN: 3642072321 ISBN-13(EAN): 9783642072321 Издательство: Springer Рейтинг: Цена: 36570.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tubingen.
The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiation of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, was the highlight of the Year of Alzheimer. However, beyond these few months of tributes, the centennial offers a unique opportunity to assess both the progress achieved and the uncertainties remaining. This volume, a collection comprised mainly of articles by the invited speakers and also of a few other prominent researchers, is meant to be a record of those events.
Описание: Due to rapidly aging populations, the number of people worldwide experiencing dementia is increasing, and the projections are grim. Despite billions of dollars invested in medical research, no effective treatment has been discovered for Alzheimer`s disease, the most common form of dementia. The Alzheimer Conundrum exposes the predicaments embedded
Автор: de la Torre Название: Alzheimer`s Turning Point ISBN: 3319340565 ISBN-13(EAN): 9783319340562 Издательство: Springer Рейтинг: Цена: 12577.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.
Автор: Farooqui, Akhlaq A. Название: Neurochemical Aspects of Alzheimer Disease ISBN: 0128099372 ISBN-13(EAN): 9780128099377 Издательство: Elsevier Science Рейтинг: Цена: 13298.00 р. Наличие на складе: Поставка под заказ.
Описание:
Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders.
Автор: Steven G. Younkin; Rudolph E. Tanzi Название: Presenilins and Alzheimer`s Disease ISBN: 3642721052 ISBN-13(EAN): 9783642721052 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The role of the familial Alzheimer`s Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.
Автор: Martina Zimmermann Название: The Poetics and Politics of Alzheimer`s Disease Life-Writing ISBN: 3319443879 ISBN-13(EAN): 9783319443874 Издательство: Springer Рейтинг: Цена: 3913.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: and second, committed alleviation of caregiver burden through social support systems and altered healthcare policies requires significantly altered views about aging, dementia, and Alzheimer`s patients.
Автор: Davis Название: Alzheimer Talk, Text and Context ISBN: 1403935327 ISBN-13(EAN): 9781403935328 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This collection augments clinical inventories of Alzheimer`s studies with an emphasis on the ways caregivers and researchers can focus on communication enhancement and person-centered care. The contributors examine discourse boundaries and social relationships, gender-cued interaction and life-course analysis, online text by and about Alzheimer`s
Автор: Ken S. Kosik; Dennis J. Selkoe Название: Alzheimer`s Disease: Lessons from Cell Biology ISBN: 3642794254 ISBN-13(EAN): 9783642794254 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer`s disease was descriptive, and lay in the province of pathologists.
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