The Living Brain and Alzheimer`s Disease, Bradley T. Hyman; Jean-Francois Demonet

Автор: Farooqui, Akhlaq A.
Название: Neurochemical Aspects of Alzheimer Disease
ISBN: 0128099372 ISBN-13(EAN): 9780128099377
Издательство: Elsevier Science
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Цена: 13298.00 р.
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Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders.

Автор: Atta-ur-Rahman
Название: Drug Design and Discovery in Alzheimer`s Disease
ISBN: 0128039590 ISBN-13(EAN): 9780128039595
Издательство: Elsevier Science
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Цена: 15159.00 р.
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Drug Design and Discovery in Alzheimer's Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of -amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery.

Автор: Ken S. Kosik; Dennis J. Selkoe
Название: Alzheimer`s Disease: Lessons from Cell Biology
ISBN: 3642794254 ISBN-13(EAN): 9783642794254
Издательство: Springer
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Цена: 20896.00 р.
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Описание: Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer`s disease was descriptive, and lay in the province of pathologists.

Автор: Yoshikuni Mizuno; Abraham Fisher; Israel Hanin
Название: Mapping the Progress of Alzheimer`s and Parkinson`s Disease
ISBN: 1475709730 ISBN-13(EAN): 9781475709735
Издательство: Springer
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Цена: 26122.00 р.
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Описание: 1h The 5 International Conference on the Progress in Alzheimer`s Disease and Parkinson`s 51 1 Disease took place from March 31 to April 5 \ 2001 in Kroto, Japan. This international 1 conference was organized as a joint Congress with the 9 International Catecholamine Symposium.

Автор: Bradley T. Hyman; Charles Duyckaerts
Название: Connections, Cognition and Alzheimer`s Disease
ISBN: 3642645046 ISBN-13(EAN): 9783642645044
Издательство: Springer
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Цена: 16979.00 р.
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Автор: Steven G. Younkin; Rudolph E. Tanzi
Название: Presenilins and Alzheimer`s Disease
ISBN: 3642721052 ISBN-13(EAN): 9783642721052
Издательство: Springer
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Цена: 19591.00 р.
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Описание: The role of the familial Alzheimer`s Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.

Автор: de la Torre
Название: Alzheimer`s Turning Point
ISBN: 3319340565 ISBN-13(EAN): 9783319340562
Издательство: Springer
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Цена: 12577.00 р.
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Описание: This compelling text provides an overview of the available technology for early detection and therapeutic management of vascular risk factors to Alzheimer’s before severe cognitive impairment symptoms appear. Chapters bring the reader from the trackless clinical research that has characterized Alzheimer’s progress for the last 20 years, to a nexus of new ideas and concepts that can change our outlook of this dementia. In-depth examinations of various hypotheses, preventive measures, current and prospective treatments are openly and clearly explored. The author discusses in depth his proposal of the vascular hypothesis of Alzheimer's disease which has become a mother-lode for basic and clinical studies and a key approach to the prevention of this dementia.Alzheimer’s Turning Point offers professionals, students and those looking to learn more about this disorder a fresh clinical perspective of this devastating disease.

Автор: Mathias Jucker; Konrad Beyreuther; Christian Haass
Название: Alzheimer: 100 Years and Beyond
ISBN: 3642072321 ISBN-13(EAN): 9783642072321
Издательство: Springer
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Цена: 36570.00 р.
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Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tubingen.

The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiation of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, was the highlight of the Year of Alzheimer. However, beyond these few months of tributes, the centennial offers a unique opportunity to assess both the progress achieved and the uncertainties remaining. This volume, a collection comprised mainly of articles by the invited speakers and also of a few other prominent researchers, is meant to be a record of those events.

Автор: Suzanne Craft
Название: Diabetes, Insulin and Alzheimer`s Disease
ISBN: 3642262813 ISBN-13(EAN): 9783642262814
Издательство: Springer
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Цена: 26120.00 р.
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Описание: This text provides a broad survey of the role of insulin in the brain. And it discusses the mechanisms through which insulin dysregulation contributes to the development of cognitive impairment and late-life neurodegenerative disease.

Автор: Michael R. D`Andrea
Название: Intracellular Consequences of Amyloid in Alzheimer`s Disease
ISBN: 0128042567 ISBN-13(EAN): 9780128042564
Издательство: Elsevier Science
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Цена: 8083.00 р.
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Описание: . Consequences of Intracellular Amyloid in Alzheimer’s Disease addresses one of the more currently unresolved aspects confounding Alzheimer’s research, the significance of intraneuronal amyloid. It seeks to explain some of the unresolved questions concerning intracellular amyloid and its origin, entry, and toxicity. . Following up on Dr. D’Andrea’s first book, Bursting Neurons and Fading Memories: An Alternative Hypothesis for the Pathogenesis of Alzheimer’s Disease, this book further examines the Inside-Out or Bursting alternative hypothesis of how amyloid escapes the circulatory system to ultimately enter neurons, also examining whether there is a relationship between intracellular amyloid, amyloid plaques, and cognitive impairment. Through a comprehensive explanation of the currently relevant scientific research on intracellular amyloid compiled in this handy reference, readers will better understand the mechanisms that lead to neuron death.

Автор: Derreumaux Philippe
Название: Alzheimer`s Disease: Insights into Low Molecular Weight and
ISBN: 1848167547 ISBN-13(EAN): 9781848167544
Издательство: World Scientific Publishing
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Цена: 22968.00 р.
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Описание: Alzheimer`s disease is the most common form of senile dementia, affecting more than 24 million people worldwide. This book provides a panoramic view across in vitro and in vivo studies along with computer simulations, designed to increase the readers` understanding of oligomerisation and fibril formation.

Автор: Patricia S. Churchland
Название: Neurophilosophy and Alzheimer`s Disease
ISBN: 364246761X ISBN-13(EAN): 9783642467615
Издательство: Springer
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Цена: 16979.00 р.
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Описание: Any mention of the relationship, still poorly understood, between body (or brain) and mind invariably invokes the name of Descartes, who is often thought of as the father of modern philosophy and perhaps of neurophilosophy.