Steroid Hormone Resistance, George P. Chrousos; D. Lynn Loriaux; Mortimer B. L

Автор: G.A.W. Rook; S. Lightman
Название: Steroid Hormones and the T-Cell Cytokine Profile
ISBN: 1447112385 ISBN-13(EAN): 9781447112389
Издательство: Springer
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Описание: The fact that certain adrenal steroid hormones are immunosuppressive and anti-inflammatory has been known for many years, and is routinely exploited by physicians. These effects are attributable to glucocorticoid steroids such as cortisol. Pharmacological doses of glucocorticoids inhibit most or all T cell types. However we now know that the effect of exposure to raised physiological levels is mainly to drive developing lymphocyte responses towards a Th2 cytokine profile (interleukin-4 secreting) while suppressing the development ofThi (gamma interferon- secreting) lymphocytes. Only recently have two further regulatory mechanisms become appar- ent. First, these effects of cortisol are balanced by pro-inflammatory and ThI-enhancing effects of another adrenal steroid, dehydroepiandro- sterone sulfate (DHEAS). Second, the activity of cortisol is directly modulated by enzymes in the target organs and lymphoid tissues that convert it into inactive cortisone. This new information leads to the possibility that immunoregulatory steroids could be used by physicians in novel ways. We can envisage steroid combinations that exploit the anti-inflammatory effects of corti- sol, while the Thi-suppressing and Th2-promoting properties of these hormones are opposed by derivatives of DHEAS. Such therapies are already proving effective in animal models of infection, and could revol- utionize treatment of Th2-mediated diseases such as asthma, where the anti-inflammatory effects of cortisol are desirable but the effects on T lymphocyte differentiation are not.

Автор: Arun K. Roy; James H. Clark
Название: Gene Regulation by Steroid Hormones IV
ISBN: 1461281970 ISBN-13(EAN): 9781461281979
Издательство: Springer
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Описание: The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds.

Автор: Arun K. Roy; James H. Clark
Название: Gene Regulation by Steroid Hormones III
ISBN: 1461291143 ISBN-13(EAN): 9781461291145
Издательство: Springer
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Цена: 19591.00 р.
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Описание: . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Автор: Luck Martin
Название: Hormones: A Very Short Introduction
ISBN: 0199672873 ISBN-13(EAN): 9780199672875
Издательство: Oxford Education
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Описание: Hormones are vital to the workings of the body, and while many people are aware of what hormones do, few have an appreciation of the nature and importance of the endocrine system. In this Very Short Introduction, Martin Luck explains what hormones are, what they do, where they come from, and how they work.

Автор: Lieberman Benjamin A.
Название: Steroid Receptor Methods / Protocols and Assays
ISBN: 0896037541 ISBN-13(EAN): 9780896037540
Издательство: Springer
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Описание: A distinguished team of principal investigators and their associates describe in step-by-step detail a cross-section of the latest research techniques available for studying the endocrine system. As a basis for sophisticated biochemical analysis of receptor properties, the contributors provide methods for the production and purification of a variety of receptors, including progesterone, glucocorticoid, and androgen. Other protocols allow the reader to experiment with DNA binding characteristics, hormone binding assays, and the use of combinatorial chemistry for drug discovery. A series of novel methods utilizing the latest advances in immunochemistry, yeast two-hybrid screening, and fluorescence are included for the detection and analysis of a variety of cellular proteins that influence steroid receptor effectiveness.

Автор: A.K. Roy; J.H. Clark
Название: Gene Regulation by Steroid Hormones II
ISBN: 1461254841 ISBN-13(EAN): 9781461254843
Издательство: Springer
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Цена: 19591.00 р.
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Описание: Receptors and Gene Expression It is now more than three years since the last Meadow Brook Conference on Hormones, and a great deal has happened in the meantime. Steroid hormones have been localized on target genes providing the long awaited evidence for the concept of a direct effect of the steroid-receptor complex on gene regulation.

Автор: Michael N. Alexis; Constantin E. Sekeris
Название: Activation of Hormone and Growth Factor Receptors
ISBN: 9401073643 ISBN-13(EAN): 9789401073646
Издательство: Springer
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Описание: Proceedings of the NATO Advanced Research Workshop, Nafplion, Greece, September 25-30, 1988