Plant Epigenetics and Epigenomics, Charles Spillane; Peter C. McKeown

Автор: Randy L. Jirtle; Frederick L. Tyson
Название: Environmental Epigenomics in Health and Disease
ISBN: 3642368263 ISBN-13(EAN): 9783642368264
Издательство: Springer
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Цена: 30039.00 р.
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Описание: This book highlights the correlation between environmental exposure during early development, and diseases such as autism, addiction, neurological diseases, diabetes, obesity and cancer. Includes a chapter on the legal and ethical implications of epigenetics.

Автор: Trygve Tollefsbol
Название: Medical Epigenetics
ISBN: 0128032391 ISBN-13(EAN): 9780128032398
Издательство: Elsevier Science
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Цена: 22696.00 р.
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Описание: "

Medical Epigenetics" is an inclusive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic disease that affect these systems, and modes of treating epigenetic-based disorders and diseases. This book provides stand-alone coverage of all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. It is useful not only to physicians, nurses, medical students, and many others directly involved with healthcare, but also investigators in life sciences, biotech companies, graduate students, and all others who are interested in more applied aspects of epigenetics.

The expansion of the field of epigenetics has brought a wealth of information with respect to variations in phenotypes that are heritable. In addition, many advances have emerged that have shown epigenetic aberrations as central to a number of diseases and disorders that were previously thought to be manifested primarily through genetic factors. Along with the remarkable studies that have been made in our understanding of epigenetic-based diseases and disorders has come new information that allows treatments that target these many epigenetic aberrations. "Medical Epigenetics" brings all of this knowledge together to comprehensively review the state of medical epigenetics in one defining volume.

The basic design of "Medical Epigenetics" is to lead the reader from the fundamental mechanisms of epigenetics as they apply to humans through approaches for treating epigenetic-based diseases. This book begins with the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics. "Medical Epigenetics" closes with a chapter on future prospects in medical epigenetics. This book is by far the most complete book in the area of applied epigenetics.
Focuses on practical and applied aspects of medical epigeneticsIncludes peer-reviewed chapters with up-to-date coverage of emerging topics in medical epigenetics by leading expertsAppeals to those interested in fundamental epigenetics and inheritance, as well as those with more clinical interests including practicing physicians and other health care professionalsCovers the basic tenets of epigenetics in human systems and progresses through general medical aspects of epigenetics, epigenetics or system disorders, multi-system medical epigenetics, pharmacology of epigenetics, and therapeutic epigenetics

Автор: Igor Kovalchuk; Franz J. Zemp
Название: Plant Epigenetics
ISBN: 1493957562 ISBN-13(EAN): 9781493957569
Издательство: Springer
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Цена: 19564.00 р.
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Описание: The discovery of DNA as the genetic material brought great hope to scientists all over the world. It was believed that many of the lingering questions in genetics and the mechanisms of heredity would fnally be answered. However, as often is the case in science, more qu- tions arose out of this discovery. What defnes a gene? What are the mechanisms of gene regulation? Further discovery and technological innovations brought about sequencing techniques that allowed the study of complete genomes from many organisms, including Arabidopsis and humans. Despite all the excitement surrounding these technologies, many features of the genome remained unclear. Peculiar characteristics in genome composition such as signifcant redundancy consisting of many repetitive elements and noncoding sequences, active transcriptional units with no protein product, and unusual sequences in promoter regions added to the mysteries of genetic make-up and gene regulation. Indeed, the more we discovered about the genome, the more diffcult it became to understand the complexity of cellular function and regulation. Out of the study of the intricacies of the genome and gene regulation, arose a new science that was independent of actual DNA changes, but critical in maintaining gene regulation and genetic stability. Epigenetics, literally translated as “above genetics,” is the science that describes the mechanisms of heritable changes in gene regulation that does not involve modifcations of DNA sequence. These changes may last through somatic cell division and, in some cases, throughout multiple generations.

Автор: Sophie Rousseaux; Saadi Khochbin
Название: Epigenetics and Human Reproduction
ISBN: 3642265820 ISBN-13(EAN): 9783642265822
Издательство: Springer
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Цена: 28732.00 р.
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Описание: The rapidly expanding field of epigenetics examines heritable traits that are not attributable to changes in the DNA sequence. Edited by two preeminent experts, this volume is part of a wider series and analyzes the role of epigenetics in human reproduction.

Автор: Francis Richard C.
Название: Epigenetics: How Environment Shapes Our Genes
ISBN: 039334228X ISBN-13(EAN): 9780393342284
Издательство: Wiley
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Цена: 2058.00 р.
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Описание: Goodbye, genetic blueprint. . . . The first book for general readers on the game-changing field of epigenetics.

Автор: Charles Spillane; Peter C. McKeown
Название: Plant Epigenetics and Epigenomics
ISBN: 1493962299 ISBN-13(EAN): 9781493962297
Издательство: Springer
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Цена: 14673.00 р.
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Описание: Many fundamental discoveries concerning epigenetics and the elucidation of mechanisms of epigenetic regulation have developed from studies performed in plants.

Автор: Randy L Jirtle; Frederick L. Tyson
Название: Environmental Epigenomics in Health and Disease
ISBN: 3642427286 ISBN-13(EAN): 9783642427282
Издательство: Springer
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Цена: 32142.00 р.
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Описание: There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Автор: Randy L. Jirtle; Frederick L. Tyson
Название: Environmental Epigenomics in Health and Disease
ISBN: 3642435955 ISBN-13(EAN): 9783642435959
Издательство: Springer
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Цена: 32142.00 р.
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Описание: There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this two volume book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. Consequently, epigenetic research promises to markedly improve our ability to diagnosis, prevent, and treat the pathological conditions of humans; however, it also introduces unique legal and ethical issues. This volume highlights the correlation between environmental factors and complex diseases, such as autism, addiction, neurological diseases, diabetes, obesity and cancer. It concludes with a chapter on legal and ethical implications of epigenetics.

Автор: Kovalchuk
Название: Plant Epigenetics
ISBN: 1489977066 ISBN-13(EAN): 9781489977069
Издательство: Springer
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Цена: 19564.00 р.
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Описание: Thisvolume provides a variety of protocols to analyze various epigeneticchanges, including differential expression of non-coding RNAs, changes in DNAmethylation, and histone modifications in plants. Chapters detail protocolswith different degrees of complexity, and describe bioinformatics approachesfor data processing and analysis. Written in the highly successful Methodsin Molecular Biology series format, chapters include introductions to theirrespective topics, lists of the necessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips on troubleshooting andavoiding known pitfalls.Authoritative andcutting-edge, Plant Epigenetics: Methods and Protocols, Second Editionaims to ensure successful results in the further study of this vital field.

Автор: Nikolaus Rajewsky; Stefan Jurga; Jan Barciszewski
Название: Plant Epigenetics
ISBN: 3319555197 ISBN-13(EAN): 9783319555195
Издательство: Springer
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Цена: 34937.00 р.
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Описание: Discussing areas ranging from the complex regulation of stress and heterosis to the precise mechanisms of DNA and histone modifications, it presents breakthroughs in our understanding of complex phenotypic phenomena.

Автор: Igor Kovalchuk; Franz J. Zemp
Название: Plant Epigenetics
ISBN: 1607616459 ISBN-13(EAN): 9781607616450
Издательство: Springer
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Цена: 20263.00 р.
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Описание: Epigenetics is one of the most popular and quickly evolving fields of modern science. In this book, expert researchers explore the most recent developments, examining in great detail the contribution of epigenetic regulation to cell function in plants.

Автор: Arturas Petronis; Jonathan Mill
Название: Brain, Behavior and Epigenetics
ISBN: 3642268323 ISBN-13(EAN): 9783642268328
Издательство: Springer
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Цена: 28732.00 р.
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Описание: Epigenetics, once believed stable after development, has been found to occur in fully differentiated, post-mitotic central nervous system cells in response to environmental signals. This book explores the role of epigenetic risk factors in complex diseases.