Development of Antibody-Based Therapeutics, Mohammad A. Tabrizi; Gadi G. Bornstein; Scott L. K
Автор: Steven J. Shire; Wayne Gombotz; Karoline Bechtold- Название: Current Trends in Monoclonal Antibody Development and Manufacturing ISBN: 1461424917 ISBN-13(EAN): 9781461424918 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides an understanding of the development, manufacturing techniques, and requirements of monoclonal antibodies. Covering one of the fastest growing areas of drug development, readers will find an informative text that describes the parameters for a successful regulatory submission.
Автор: Lo Benny K. C. Название: Antibody Engineering / Methods and Protocols ISBN: 1588290921 ISBN-13(EAN): 9781588290922 Издательство: Springer Рейтинг: Цена: 24456.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A core collection of diverse cutting-edge techniques for the generation, expression, optimization, and characterization of recombinant antibodies. Readily reproducible protocols for lead generation range from the cloning of human immunoglobulin genes to the selection and generation of human recombinant antibodies by humanization approaches, molecular display technologies and transgenic animals. Procedures are also described on restructuring antibody leads into monovalent, multivalent, and bispecific binding fragments for a wide variety of in vivo applications. State-of-the-art technologies are described for the characterization of antigen-binding affinity and specificity with novel applications in radioimmunotargeting, cancer immunotherapy, drug abuse, and proteomics.
Автор: Robert Aitken (Ed.) Название: Antibody Phage Display ISBN: 1603273018 ISBN-13(EAN): 9781603273015 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Поставка под заказ.
Описание: Phage display technology has revolutionized approaches to the analysis of biomedical problems, impacting the fields of immunology, cell biology, biotechnology, pharmacology, and drug discovery. This title provides a resource that guides readers in the design and execution of experiments based around antibody phage display.
Автор: Ducry Название: Antibody-Drug Conjugates ISBN: 1627035400 ISBN-13(EAN): 9781627035408 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.
Автор: Borrebaeck, Carl A. K. Название: Antibody Engineering ISBN: 0195091507 ISBN-13(EAN): 9780195091502 Издательство: Oxford Academ Рейтинг: Цена: 13306.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This text has been designed to help researchers understand and develop designer antibodies. Its practical approach makes use of state-of-the-art technologies for the production of recombinant human or mouse monoclonal antibodies.
Автор: Ulf Grawunder; Stefan Barth Название: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins ISBN: 3319468758 ISBN-13(EAN): 9783319468754 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.
The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Автор: Brandon DeKosky Название: Decoding the Antibody Repertoire ISBN: 3319585177 ISBN-13(EAN): 9783319585178 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This thesis outlines the development of the very first technology for high-throughput analysis of paired heavy and light-chain antibody sequences, opening an entirely new window for antibody discovery and the investigation of adaptive immune responses to vaccines and diseases.
Previous methods for high-throughput immune repertoire sequencing have been unable to provide information on the identity of immune receptor pairs encoded by individual B or T lymphocytes. The author directly addresses these limitations by designing two new technologies for sequencing multiple mRNA transcripts from up to 10 million isolated, single cells.
The techniques developed in this work have enabled comprehensive interrogation of human B-cell repertoires and have been applied for rapid discovery of new human antibodies, to gain new insights into the development of human antibody repertoires, and for analysis of human immune responses to vaccination and disease.
Автор: Laurent Ducry Название: Antibody-Drug Conjugates ISBN: 1493960261 ISBN-13(EAN): 9781493960262 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents detailed protocols for key antibody-drug conjugates techniques necessary for working in the field. It provides step-by-step methodologies that are readily reproducible and features expert tips and key implementation advice.
Описание: In the anti-breast cancer antibody field the availability of molecular engineering approaches to humanize murine antibodies has induced intense interest in the creation of less immunogenic antibody forms that are now available for clinical testing.
ООО "Логосфера " Тел:+7(495) 980-12-10 www.logobook.ru
