Автор: Reeves Название: In Vitro Mutagenesis ISBN: 1493964704 ISBN-13(EAN): 9781493964703 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In vitro mutagenesis remains a critical experimental approach for investigating gene and protein function at the cellular level. This volume provides a wide variety of updated and novel approaches for performing in vitro mutagenesis using such methods as genome editing, transposon (Tn) mutagenesis, site-directed, and random mutagenesis. In Vitro Mutagenesis: Methods and Protocols guides readers through methods for gene and genome editing, practical bioinformatics approaches for identifying mutagenesis targets, and novel site-directed and random mutagenesis approaches aimed at gaining a better understanding of protein-protein and protein-cofactor interactions. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, In Vitro Mutagenesis: Methods and Protocols aims to provide a highly accessible and practical manual for current and future molecular biology researchers, from the beginner practitioner to the advanced investigator in fields such as molecular genetics, biochemistry, and biochemical and metabolic engineering.
Автор: Mittelman David Название: Stress-Induced Mutagenesis ISBN: 1461462797 ISBN-13(EAN): 9781461462798 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers pathways of stress-induced mutagenesis, which may yield models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and other important processes.
Автор: F. Vogel; G. R?hrborn Название: Chemical Mutagenesis in Mammals and Man ISBN: 3642858767 ISBN-13(EAN): 9783642858765 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Encouraged by the results with radiation genetics, the editors of this volume have tried since 1963 to organize a team of scientists in Heidelberg who would examine the problem of chemical mutagenesis in mammals with a variety of methods. Meanwhile, other organizations have also become interested in this problem and various teams, particularly in the U.S.A., but also in West Germany, are working in this field. This development is very auspicious; the spectrum of our methods does permit limited conclusions as to the mutagenic effects of chemical substances in mammals, but we are still far away from a thorough determination of all the genetically relevant effects. New methods must be developed. This volume is the result of a request by the Chairman of the "Gesellschaft fUr Anthropologie und Humangenetik", Frau Professor Dr. I. SCHWIDETZKY (Mainz), that one of us (F.V.) organize a symposium concerning mutation research in the framework of its annual meeting on October 7, 1969. The most sensible approach seemed to be one of centering the discussion on the test methods employed in mutagenicity research with mammals. With the aid of the Deutsche Forschungsgemeinschaft and the pharma- ceutical industry it was possible to invite scientists from the U.S.A. We wish to thank Firma Thomae, Biberach, Firma Bayer, Leverkusen, and Firma Boehringer, Mannheim, for their contributions. We wish to thank Dr. HAsso SCHROEDER especially for his efforts on our behalf.
Автор: Burnet MacFarlane Название: Intrinsic mutagenesis ISBN: 9401166080 ISBN-13(EAN): 9789401166089 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.
Автор: Adam J. Dupuy; David A. Largaespada Название: Insertional Mutagenesis Strategies in Cancer Genetics ISBN: 1489981349 ISBN-13(EAN): 9781489981349 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.
Автор: Shondra M. Pruett-Miller Название: Chromosomal Mutagenesis ISBN: 1493918613 ISBN-13(EAN): 9781493918614 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This new edition explores current and emerging mutagenesis methods focusing specifically on mammalian systems and commonly used model organisms through comprehensive coverage and detailed protocols.
Автор: Robert Feil; Daniel Metzger Название: Conditional Mutagenesis: An Approach to Disease Models ISBN: 364207121X ISBN-13(EAN): 9783642071218 Издательство: Springer Рейтинг: Цена: 65305.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Greg Davis; Kevin J. Kayser Название: Chromosomal Mutagenesis ISBN: 161737833X ISBN-13(EAN): 9781617378331 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In Chromosomal Mutagenesis, a team of experts provide a variety of chromosomal manipulation techniques, including insertional gene disruptions, gene knockouts, stimulated homologous recombination techniques and other novel tools, for both prokaryotic and eukaryotic organisms, and attempt to expand the genetic toolbox beyond model organisms.
Автор: G?nter Obe; H.H. Evans; D. Frankenberg; M. Franken Название: Advances in Mutagenesis Research ISBN: 3642762344 ISBN-13(EAN): 9783642762345 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity and cancerogenicity of chemicals and other agents.
Автор: A. Muhammed Название: Basic and Applied Mutagenesis ISBN: 1468449788 ISBN-13(EAN): 9781468449785 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: These are the same chemicals that are in use throughout the develop- ing world, although the quantities of the different types that are used may vary from country to country, and from region to region within countries.
Автор: F.A. Beland; L.G. Cain; J.S. Felton; J.D. Groopman Название: Chemical Carcinogenesis and Mutagenesis I ISBN: 3642747779 ISBN-13(EAN): 9783642747779 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: I have been privileged to witness and participate in the great growth of knowledge on chemical carcinogenesis and mutagenesis since 1939 when I entered graduate school in biochemistry at the University of Wisconsin- Madison.
Автор: Monica Justice; Mary Bedell Название: Mutagenesis of the Mouse Genome ISBN: 9401751048 ISBN-13(EAN): 9789401751049 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
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