Conditional Mutagenesis: An Approach to Disease Models, Robert Feil; Daniel Metzger

Автор: G?nter Obe; F. Cortes; P. Escalza; A. Hofmann; V.I
Название: Advances in Mutagenesis Research
ISBN: 3642774687 ISBN-13(EAN): 9783642774683
Издательство: Springer
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Автор: David Mittelman
Название: Stress-Induced Mutagenesis
ISBN: 1489994181 ISBN-13(EAN): 9781489994189
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Описание: This book covers pathways of stress-induced mutagenesis, which may yield models for genome instability underlying some cancers and genetic diseases, resistance to chemotherapeutic and antibiotic drugs, pathogenicity of microbes, and other important processes.

Автор: Burnet MacFarlane
Название: Intrinsic mutagenesis
ISBN: 9401166080 ISBN-13(EAN): 9789401166089
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Описание: The working hypothesis, which halfway through its writing became the new central theme of the book, arose when I was a member of a committee appointed by the Australian Academy of Science at the request of the Australian Government to advise on the danger from French nuclear tests in the South Pacific.

Автор: M. Bauchinger; G?nter Obe; F.K. Ennever; H. Hayats
Название: Advances in Mutagenesis Research
ISBN: 3642749577 ISBN-13(EAN): 9783642749575
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Описание: The new field of applied genetic research, genetic toxicology and mutation research investigates the mutagenicity and cancerogenicity of chemicals and other agents.

Автор: W. Generoso
Название: DNA Repair and Mutagenesis in Eukaryotes
ISBN: 1468438441 ISBN-13(EAN): 9781468438444
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Описание: Not many years ago most discussion of mutation induction by physical and chemical agents concentrated on the initial lesions induced in the DNA with the implicit assumption that once the lesions were made they were converted almost automatically to mutations by relatively simple processes associated with DNA replication.

Автор: G?nter Obe; H.H. Evans; D. Frankenberg; M. Franken
Название: Advances in Mutagenesis Research
ISBN: 3642762344 ISBN-13(EAN): 9783642762345
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Описание: Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity and cancerogenicity of chemicals and other agents.

Автор: Greg Davis; Kevin J. Kayser
Название: Chromosomal Mutagenesis
ISBN: 161737833X ISBN-13(EAN): 9781617378331
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Описание: In Chromosomal Mutagenesis, a team of experts provide a variety of chromosomal manipulation techniques, including insertional gene disruptions, gene knockouts, stimulated homologous recombination techniques and other novel tools, for both prokaryotic and eukaryotic organisms, and attempt to expand the genetic toolbox beyond model organisms.

Автор: Jeff Braman
Название: In Vitro Mutagenesis Protocols
ISBN: 1493956663 ISBN-13(EAN): 9781493956661
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Описание: In the post-genomic era, in vitro mutagenesis has emerged as a critically important tool for establishing the functions of components of the proteome. The third edition of In Vitro Mutagenesis Protocols represents a practical toolbox containing protocols vital to advancing our understanding of the connection between nucleotide sequence and sequence function. Fully updated from the previous editions, this volume contains a variety of specialty tools successfully employed to unravel the intricacies of protein-protein interaction, protein structure-function, protein regulation of biological processes, and protein activity, as well as a novel section on mutagenesis methods for unique microbes as a guide to the generalization of mutagenesis strategies for a host of microbial systems. Written in the highly successful Methods in Molecular Biology™ series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, In Vitro Mutagenesis Protocols, Third Edition offers today's researchers a valuable compendium of reliable and powerful techniques with which to illuminate the proteome and its rich web of biological implications.

Автор: Shondra M. Pruett-Miller
Название: Chromosomal Mutagenesis
ISBN: 1493918613 ISBN-13(EAN): 9781493918614
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Описание: This new edition explores current and emerging mutagenesis methods focusing specifically on mammalian systems and commonly used model organisms through comprehensive coverage and detailed protocols.

Автор: Adam J. Dupuy; David A. Largaespada
Название: Insertional Mutagenesis Strategies in Cancer Genetics
ISBN: 1489981349 ISBN-13(EAN): 9781489981349
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Описание: The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials.

Автор: F. Vogel; G. R?hrborn
Название: Chemical Mutagenesis in Mammals and Man
ISBN: 3642858767 ISBN-13(EAN): 9783642858765
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Описание: Encouraged by the results with radiation genetics, the editors of this volume have tried since 1963 to organize a team of scientists in Heidelberg who would examine the problem of chemical mutagenesis in mammals with a variety of methods. Meanwhile, other organizations have also become interested in this problem and various teams, particularly in the U.S.A., but also in West Germany, are working in this field. This development is very auspicious; the spectrum of our methods does permit limited conclusions as to the mutagenic effects of chemical substances in mammals, but we are still far away from a thorough determination of all the genetically relevant effects. New methods must be developed. This volume is the result of a request by the Chairman of the "Gesellschaft fUr Anthropologie und Humangenetik", Frau Professor Dr. I. SCHWIDETZKY (Mainz), that one of us (F.V.) organize a symposium concerning mutation research in the framework of its annual meeting on October 7, 1969. The most sensible approach seemed to be one of centering the discussion on the test methods employed in mutagenicity research with mammals. With the aid of the Deutsche Forschungsgemeinschaft and the pharma- ceutical industry it was possible to invite scientists from the U.S.A. We wish to thank Firma Thomae, Biberach, Firma Bayer, Leverkusen, and Firma Boehringer, Mannheim, for their contributions. We wish to thank Dr. HAsso SCHROEDER especially for his efforts on our behalf.

Автор: Y.F. Bogdanov; E. Dikomey; N.A. Liapunova; W.-U. M
Название: Advances in Mutagenesis Research
ISBN: 3642781950 ISBN-13(EAN): 9783642781957
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Описание: Applied genetic research, genetic toxicology and mutation research investigate the mutagenicity of chemicals and other agents. Permanent mutation in genes and chromosomes can be induced by a plethora of agents, including ionizing and nonionizing radiations, chemicals, and viruses.