Preventive and Predictive Genetics: Towards Personalised Medicine, Godfrey Grech; Iris Grossman
Автор: Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso Название: Predictive Methods in Percutaneous Absorption ISBN: 3662473704 ISBN-13(EAN): 9783662473702 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.
Автор: Minor, Jessica Название: Informed consent in predictive genetic testing ISBN: 3319385585 ISBN-13(EAN): 9783319385587 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This important book proposes revising the current informed consent protocol for predictive genetic testing to reflect the trend toward patient-centered medicine. Emphasizing the predictive aspect of testing, the author analyzes the state of informed consent procedure in terms of three components: comprehension of risk assessment, disclosure to select appropriate treatment, and voluntariness. The book's revised model revisits these cornerstones, restructuring the consent process to allow for expanded comprehension time, enhanced patient safety, greater patient involvement and autonomy, and reduced chance of coercion by family or others. A comparison of the current and revised versions and case studies showing the new model in real-world applications add extra usefulness to this resource.
Included in the coverage:
The science behind PGT.
Understanding genetic risks and probability.
The history of informed consent.
Revised model of informed consent: comprehension, disclosure, voluntariness, patient safety.
Applications of the model in DTC and pleiotropic genetic testing.
Implementation of the revised model, and assessing its effectiveness.
A milestone in the bioethics literature, Informed Consent in Predictive Genetic Testing will be of considerable interest to genetic counselors, medical and bioethicists, and public health professionals.
Автор: V. Hofmann; M.E. Berens; G. Martz Название: Predictive Drug Testing on Human Tumor Cells ISBN: 3642822975 ISBN-13(EAN): 9783642822971 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents available are few in number and show only limited activity.
Автор: Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso Название: Predictive Methods in Percutaneous Absorption ISBN: 3662508311 ISBN-13(EAN): 9783662508312 Издательство: Springer Рейтинг: Цена: 16977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation.
Описание: By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs.
Автор: Godfrey Grech; Iris Grossman Название: Preventive and Predictive Genetics: Towards Personalised Medicine ISBN: 3319153439 ISBN-13(EAN): 9783319153438 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.
Автор: Ingrid Emerit; Lester Packer; Christian Auclair Название: Antioxidants in Therapy and Preventive Medicine ISBN: 1468457322 ISBN-13(EAN): 9781468457322 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the Society for Free Radical Research Winter Meeting 1988 on Free Radicals in Medicine: Current Status of Antioxidant Therapy, held in Paris, France, December 9-10, 1988
Автор: A.N. Worden; D.V. Parke; J. Marks Название: The Future of Predictive Safety Evaluation ISBN: 9401079366 ISBN-13(EAN): 9789401079365 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents.
Автор: D.V. Parke; A.N. Worden; J. Marks Название: The Future of Predictive Safety Evaluation ISBN: 9401083363 ISBN-13(EAN): 9789401083362 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes- tament, controls have existed[l]. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London.
Автор: Jessica Minor Название: Informed Consent in Predictive Genetic Testing ISBN: 3319174150 ISBN-13(EAN): 9783319174150 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Informed Consent in Predictive Genetic Testing
Автор: Xu Название: Predictive Toxicology in Drug Safety ISBN: 0521763649 ISBN-13(EAN): 9780521763646 Издательство: Cambridge Academ Рейтинг: Цена: 19800.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a handbook on drug discovery toxicology for scientists working in this field dedicated to the development of safe drugs. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment and promotes evidence-based toxicology.
Автор: Pal, Ranadip Название: Predictive Modeling of Drug Sensitivity ISBN: 0128052740 ISBN-13(EAN): 9780128052747 Издательство: Elsevier Science Рейтинг: Цена: 12801.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Predictive Modeling of Drug Sensitivity gives an overview of drug sensitivity modeling for personalized medicine that includes data characterizations, modeling techniques, applications, and research challenges. It covers the major mathematical techniques used for modeling drug sensitivity, and includes the requisite biological knowledge to guide a user to apply the mathematical tools in different biological scenarios.
This book is an ideal reference for computer scientists, engineers, computational biologists, and mathematicians who want to understand and apply multiple approaches and methods to drug sensitivity modeling. The reader will learn a broad range of mathematical and computational techniques applied to the modeling of drug sensitivity, biological concepts, and measurement techniques crucial to drug sensitivity modeling, how to design a combination of drugs under different constraints, and the applications of drug sensitivity prediction methodologies.
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