The Future of Predictive Safety Evaluation, A.N. Worden; D.V. Parke; J. Marks

Автор: Xu
Название: Predictive Toxicology in Drug Safety
ISBN: 0521763649 ISBN-13(EAN): 9780521763646
Издательство: Cambridge Academ
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Описание: This book is a handbook on drug discovery toxicology for scientists working in this field dedicated to the development of safe drugs. It provides information on the present knowledge of drug side effects and their mitigation strategy during drug discovery, gives guidance for risk assessment and promotes evidence-based toxicology.

Автор: Wang
Название: Predictive ADMET: Integrated Approaches in Drug Discovery and Development
ISBN: 1118299922 ISBN-13(EAN): 9781118299920
Издательство: Wiley
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Цена: 21376.00 р.
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Описание: By guiding in the application of techniques and tools for predicting ADMET outcomes in drug candidates, Predictive ADMET offers a road map for drug discovery scientists to generate effective and safe drugs for unmet medical needs.

Автор: V. Hofmann; M.E. Berens; G. Martz
Название: Predictive Drug Testing on Human Tumor Cells
ISBN: 3642822975 ISBN-13(EAN): 9783642822971
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Predictive drug testing on human tumor cells in order to define the appropriate chemotherapy will remain imperative as long as the anticancer agents available are few in number and show only limited activity.

Автор: Gad
Название: Drug Safety Evaluation, 2nd Edition
ISBN: 0470253169 ISBN-13(EAN): 9780470253168
Издательство: Wiley
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Цена: 25186.00 р.
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Описание: Government regulatory agencies must approve any drug before it can be sold. This book presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. It also addresses specific approaches to evaluating hazards, including problems and solutions.

Автор: Jean-Charles Gautier
Название: Drug Safety Evaluation
ISBN: 1493956698 ISBN-13(EAN): 9781493956692
Издательство: Springer
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Цена: 20263.00 р.
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Описание: These meticulous contributions feature key topics such as acute to chronic general toxicity studies, histopathology studies, reproductive toxicity studies, genotoxicity studies, safety pharmacology studies, investigative toxicity studies, and safety biomarker studies.

Автор: Jean-Charles Gautier
Название: Drug Safety Evaluation
ISBN: 1493971700 ISBN-13(EAN): 9781493971701
Издательство: Springer
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Цена: 20962.00 р.
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Описание: Part I: General Toxicology

1. Nonclinical Development of Combination Drugs

18. Evaluation of Embryotoxicity Using

Автор: D.V. Parke; A.N. Worden; J. Marks
Название: The Future of Predictive Safety Evaluation
ISBN: 9401083363 ISBN-13(EAN): 9789401083362
Издательство: Springer
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Цена: 12157.00 р.
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Описание: The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes- tament, controls have existed[l]. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London.

Автор: Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso
Название: Predictive Methods in Percutaneous Absorption
ISBN: 3662473704 ISBN-13(EAN): 9783662473702
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models. The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Автор: Pal, Ranadip
Название: Predictive Modeling of Drug Sensitivity
ISBN: 0128052740 ISBN-13(EAN): 9780128052747
Издательство: Elsevier Science
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Цена: 12801.00 р.
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Описание:

Predictive Modeling of Drug Sensitivity gives an overview of drug sensitivity modeling for personalized medicine that includes data characterizations, modeling techniques, applications, and research challenges. It covers the major mathematical techniques used for modeling drug sensitivity, and includes the requisite biological knowledge to guide a user to apply the mathematical tools in different biological scenarios.

Автор: Gary P. Moss; Darren R. Gullick; Simon C. Wilkinso
Название: Predictive Methods in Percutaneous Absorption
ISBN: 3662508311 ISBN-13(EAN): 9783662508312
Издательство: Springer
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Цена: 16977.00 р.
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Описание: This book sheds new light on the development and use of quantitative models to describe the process of skin permeation.

Автор: Godfrey Grech; Iris Grossman
Название: Preventive and Predictive Genetics: Towards Personalised Medicine
ISBN: 3319380575 ISBN-13(EAN): 9783319380575
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Автор: Godfrey Grech; Iris Grossman
Название: Preventive and Predictive Genetics: Towards Personalised Medicine
ISBN: 3319153439 ISBN-13(EAN): 9783319153438
Издательство: Springer
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Цена: 22359.00 р.
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Описание: Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.