Neurobiology of the Trace Amines, Alan A. Boulton; Glen B. Baker; William G. Dewhurs

Автор: Farooqui, Tahira
Название: Trace Amines and Neurological Disorders
ISBN: 0128036036 ISBN-13(EAN): 9780128036037
Издательство: Elsevier Science
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Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders.

Автор: Alan A. Boulton; Glen B. Baker; Judith M. Baker
Название: Amines and Their Metabolites
ISBN: 0896030768 ISBN-13(EAN): 9780896030763
Издательство: Springer
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Автор: Alan A. Boulton; Glen B. Baker; William G. Dewhurs
Название: Neurobiology of the Trace Amines
ISBN: 1461297818 ISBN-13(EAN): 9781461297819
Издательство: Springer
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Автор: Alan A. Boulton; Peter R. Bieck; L. Maitre; P. Rie
Название: Neuropsychopharmacology of the Trace Amines
ISBN: 0896030997 ISBN-13(EAN): 9780896030992
Издательство: Springer
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Описание: A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed.

Автор: Alan A. Boulton; A. V. Juorio; R. G. H. Downer
Название: Trace Amines
ISBN: 1461289459 ISBN-13(EAN): 9781461289456
Издательство: Springer
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Описание: This is the third Proceedings book to arise from biennial conferen- ces on the Trace Amines. Since our first meeting in 1983 in Edmonton, Canada, progress has been brisk and, as will be seen from the ensuing pages, it is now possible to include major contributions from inverte- brate neurobiologists as well as receptorologists. In the opening ses- sion we heard about the distribution of the trace amines-now clear- ly a misnomer-in insects and the pharmacological, receptor, and syn- aptic characteristics of octopamine and tryptamine as well as the pos- sibility of monoamines in general being targets for insecticide discov- ery. In mammalian brain the distribution and characterization of the tryptamine receptor has proceeded to the point where two types have been described as well as novel agonists and antagonists, and, for the first time, a binding site for p-tyramine has been described. The com- bination of lesions and pharmacological and metabolic manipulations now permits the mapping of trace aminergic pathways, and the rap- idly accumulating evidence from releasing drugs, in situ microdialy- sis, iontophoresis, and second messenger systems lends credence to the claim that the trace amines possess neuromodulatory functions.

Автор: Alan A. Boulton; A. V. Juorio; R. G. H. Downer
Название: Trace Amines
ISBN: 0896031446 ISBN-13(EAN): 9780896031449
Издательство: Springer
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Описание: This volume reflects the progress that has been made in the field of trace amines.

Автор: Alan A. Boulton; Glen B. Baker; Judith M. Baker
Название: Amines and Their Metabolites
ISBN: 1489941258 ISBN-13(EAN): 9781489941251
Издательство: Springer
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Автор: Peter Riederer; Moussa B.H. Youdim
Название: Amine Oxidases and Their Impact on Neurobiology
ISBN: 3211822399 ISBN-13(EAN): 9783211822395
Издательство: Springer
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Описание: Describes the most recent research in the field of monoamine oxidase (MAO), diamine oxidase and semicarbazide-sensitive amine oxidase. The roles of catechol-O-methyltransferase, sulfation and up-take processes are also discussed in detail.

Автор: Ivor E. Dreosti; Richard M. Smith
Название: Neurobiology of the Trace Elements
ISBN: 1475759592 ISBN-13(EAN): 9781475759594
Издательство: Springer
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Описание: More recently I have developed a rather more specific interest in the role of zinc, particularly in relation to the dominance of zinc metalloenzymes in the processes of DNA replication and repair, and its possible significance for human pathology.

Автор: Ivor E. Dreosti; Richard M. Smith
Название: Neurobiology of the Trace Elements
ISBN: 0896030466 ISBN-13(EAN): 9780896030466
Издательство: Springer
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Описание: This text is a treatise drawing together and critically examining the current explosion of experimental and clinical research on the metabolism, nutrition, pharmacology, toxicology, pathology, neuropsychology, and developmental neurobiology of trace elements.

Автор: Charney Dennis, Sklar Pamela, Buxbaum Joseph
Название: Neurobiology of Mental Illness
ISBN: 0199398461 ISBN-13(EAN): 9780199398461
Издательство: Oxford Academ
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Описание: Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Автор: Lajtha,A.(Eds)
Название: Hdbk Neurochemistry, Molec.Neurobiology: Pract.Neurochem.
ISBN: 0387303596 ISBN-13(EAN): 9780387303598
Издательство: Springer
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Описание: The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies.