Trace Amines, Alan A. Boulton; A. V. Juorio; R. G. H. Downer

Автор: Alan A. Boulton; Glen B. Baker; William G. Dewhurs
Название: Neurobiology of the Trace Amines
ISBN: 0896030636 ISBN-13(EAN): 9780896030633
Издательство: Springer
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Описание: Many of the trace amines-more correctly called biogenic amines- have been known for decades, but because of their tiny concentra- tions (0. 01-100 ng/g) in brain, it was only after the development of sophisticated analytical techniques (such as mass spectrometry) that they could be identified and quantitated in nervous tissue. There are now more than 20 of them and most are related to the catecholamines and 5-hydroxytryptamine both structurally and metabolically. Their pharmacological and physiological properties make them prime candidates for a transmitter or neuromodulator role and many of them elicit profound behavioral syndromes after injection--one of them, phenylethylamine, has even been referred to as nature's amphetamine. In the clinical sphere several have been shown to be involved in: Parkinsonism, schizophrenia, depression, agoraphobia, aggression, hyperkinesis, migraine, hypertensive crises, hypertyrosinemia, he- patic encephalopathy, epilepsy, and cystic fibrosis. Thus the research reported here on these intriguing "new" substances will be of great interest to psychiatrists, neurologists, biochemists, pharmacologists, physiologists, psychologists, behaviorists and indeed to all those working in the neurosciences and related fields today. ACKNOWLEDGMENTS This book is based on the proceedings of Trace Amines and the Neurosciences, a meeting held at the University of Alberta, Edmonton, July 19-21, 1983. This meeting was organized as a Satellite Meeting of the Ninth Meeting of the International Society for Neurochemistry, held in Vancouver, July 10-15, 1983. International organizers of the satellite meeting were Drs. A. A. Boulton (Saskatoon), W. G. Dewhurst (Edmonton), G. B. Baker (Edmonton), and M. Sandler (London).

Автор: Alan A. Boulton; Peter R. Bieck; L. Maitre; P. Rie
Название: Neuropsychopharmacology of the Trace Amines
ISBN: 1461293979 ISBN-13(EAN): 9781461293972
Издательство: Springer
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Описание: A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed.

Автор: Alan A. Boulton; A. V. Juorio; R. G. H. Downer
Название: Trace Amines
ISBN: 0896031446 ISBN-13(EAN): 9780896031449
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Описание: This volume reflects the progress that has been made in the field of trace amines.

Автор: Alan A. Boulton; Peter R. Bieck; L. Maitre; P. Rie
Название: Neuropsychopharmacology of the Trace Amines
ISBN: 0896030997 ISBN-13(EAN): 9780896030992
Издательство: Springer
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Описание: A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed.

Автор: Alan A. Boulton; Glen B. Baker; William G. Dewhurs
Название: Neurobiology of the Trace Amines
ISBN: 1461297818 ISBN-13(EAN): 9781461297819
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Автор: Farooqui, Tahira
Название: Trace Amines and Neurological Disorders
ISBN: 0128036036 ISBN-13(EAN): 9780128036037
Издательство: Elsevier Science
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Описание:

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders.

Автор: Alan A. Boulton; Glen B. Baker; Judith M. Baker
Название: Amines and Their Metabolites
ISBN: 0896030768 ISBN-13(EAN): 9780896030763
Издательство: Springer
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Автор: Alan A. Boulton; Glen B. Baker; Judith M. Baker
Название: Amines and Their Metabolites
ISBN: 1489941258 ISBN-13(EAN): 9781489941251
Издательство: Springer
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Автор: Peter Riederer; Moussa B.H. Youdim
Название: Amine Oxidases and Their Impact on Neurobiology
ISBN: 3211822399 ISBN-13(EAN): 9783211822395
Издательство: Springer
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Описание: Describes the most recent research in the field of monoamine oxidase (MAO), diamine oxidase and semicarbazide-sensitive amine oxidase. The roles of catechol-O-methyltransferase, sulfation and up-take processes are also discussed in detail.