Neuropsychopharmacology of the Trace Amines, Alan A. Boulton; Peter R. Bieck; L. Maitre; P. Rie

Автор: Iversen, PhD, Leslie; Iversen, PhD, Susan; Bloom,
Название: Introduction to Neuropsychopharmacology
ISBN: 0195380533 ISBN-13(EAN): 9780195380538
Издательство: Oxford Academ
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Описание: Introduction to Neuropsychopharmacology expands on the molecular and cellular foundations of the classic Biochemical Basis of Neuropharmacology, Eighth Edition (Cooper, Bloom, and Roth) by now including the behavioral methods used to study psychoactive drugs in experimental animals and in
humans. Authored by four founders of modern neuroscience, this concise and comprehensive text covers the current series of medications used to treat diseases of the brain and nervous system--both psychiatric and neurologic--as well as legal and illegal recreational drugs and the neuroscientific
information that explains how these medications act on the brain from the molecular to the clinical level. The text ranges from drugs that affect the mood and behavior to hypnotics, narcotics, anticonvulsants, and analgesics.

Автор: Alan A. Boulton; A. V. Juorio; R. G. H. Downer
Название: Trace Amines
ISBN: 1461289459 ISBN-13(EAN): 9781461289456
Издательство: Springer
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Описание: This is the third Proceedings book to arise from biennial conferen- ces on the Trace Amines. Since our first meeting in 1983 in Edmonton, Canada, progress has been brisk and, as will be seen from the ensuing pages, it is now possible to include major contributions from inverte- brate neurobiologists as well as receptorologists. In the opening ses- sion we heard about the distribution of the trace amines-now clear- ly a misnomer-in insects and the pharmacological, receptor, and syn- aptic characteristics of octopamine and tryptamine as well as the pos- sibility of monoamines in general being targets for insecticide discov- ery. In mammalian brain the distribution and characterization of the tryptamine receptor has proceeded to the point where two types have been described as well as novel agonists and antagonists, and, for the first time, a binding site for p-tyramine has been described. The com- bination of lesions and pharmacological and metabolic manipulations now permits the mapping of trace aminergic pathways, and the rap- idly accumulating evidence from releasing drugs, in situ microdialy- sis, iontophoresis, and second messenger systems lends credence to the claim that the trace amines possess neuromodulatory functions.

Автор: Alan A. Boulton; Peter R. Bieck; L. Maitre; P. Rie
Название: Neuropsychopharmacology of the Trace Amines
ISBN: 1461293979 ISBN-13(EAN): 9781461293972
Издательство: Springer
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Описание: A probable neurobiological role for the trace amines began to emerge as soon as techniques sufficiently sophisticated to detect them were developed.

Автор: Ebenezer Ivor
Название: Neuropsychopharmacology and Therapeutics
ISBN: 1118385659 ISBN-13(EAN): 9781118385654
Издательство: Wiley
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Описание: Neuropsychopharmacology is a relatively new subject area in the neurosciences.

Автор: W.E. Jr. Bunney; Hanns Hippius; Gregor Laakmann; M
Название: Neuropsychopharmacology
ISBN: 3642740367 ISBN-13(EAN): 9783642740367
Издательство: Springer
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Автор: Robbins
Название: Translational Neuropsychopharmacology
ISBN: 3319339117 ISBN-13(EAN): 9783319339115
Издательство: Springer
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Описание: This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.

Автор: Alan A. Boulton; Glen B. Baker; William G. Dewhurs
Название: Neurobiology of the Trace Amines
ISBN: 1461297818 ISBN-13(EAN): 9781461297819
Издательство: Springer
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Автор: Farooqui, Tahira
Название: Trace Amines and Neurological Disorders
ISBN: 0128036036 ISBN-13(EAN): 9780128036037
Издательство: Elsevier Science
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Описание:

Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders.

Автор: Alan A. Boulton; A. V. Juorio; R. G. H. Downer
Название: Trace Amines
ISBN: 0896031446 ISBN-13(EAN): 9780896031449
Издательство: Springer
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Описание: This volume reflects the progress that has been made in the field of trace amines.

Автор: Alan A. Boulton; Glen B. Baker; William G. Dewhurs
Название: Neurobiology of the Trace Amines
ISBN: 0896030636 ISBN-13(EAN): 9780896030633
Издательство: Springer
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Описание: Many of the trace amines-more correctly called biogenic amines- have been known for decades, but because of their tiny concentra- tions (0. 01-100 ng/g) in brain, it was only after the development of sophisticated analytical techniques (such as mass spectrometry) that they could be identified and quantitated in nervous tissue. There are now more than 20 of them and most are related to the catecholamines and 5-hydroxytryptamine both structurally and metabolically. Their pharmacological and physiological properties make them prime candidates for a transmitter or neuromodulator role and many of them elicit profound behavioral syndromes after injection--one of them, phenylethylamine, has even been referred to as nature's amphetamine. In the clinical sphere several have been shown to be involved in: Parkinsonism, schizophrenia, depression, agoraphobia, aggression, hyperkinesis, migraine, hypertensive crises, hypertyrosinemia, he- patic encephalopathy, epilepsy, and cystic fibrosis. Thus the research reported here on these intriguing "new" substances will be of great interest to psychiatrists, neurologists, biochemists, pharmacologists, physiologists, psychologists, behaviorists and indeed to all those working in the neurosciences and related fields today. ACKNOWLEDGMENTS This book is based on the proceedings of Trace Amines and the Neurosciences, a meeting held at the University of Alberta, Edmonton, July 19-21, 1983. This meeting was organized as a Satellite Meeting of the Ninth Meeting of the International Society for Neurochemistry, held in Vancouver, July 10-15, 1983. International organizers of the satellite meeting were Drs. A. A. Boulton (Saskatoon), W. G. Dewhurst (Edmonton), G. B. Baker (Edmonton), and M. Sandler (London).

Автор: Alan A. Boulton; Glen B. Baker; Judith M. Baker
Название: Amines and Their Metabolites
ISBN: 0896030768 ISBN-13(EAN): 9780896030763
Издательство: Springer
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Автор: Alan A. Boulton; Glen B. Baker; Judith M. Baker
Название: Amines and Their Metabolites
ISBN: 1489941258 ISBN-13(EAN): 9781489941251
Издательство: Springer
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