Описание: This new publication in the Methods in Molecular Biology series sets out detailed protocols for the targeted bioinformatics procedures dedicated to RNA structure. It features practical and algorithmic approaches as well as expert problem-solving advice.
Описание: The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.
Автор: Tieng K. Yap; Ophir Frieder; Robert L. Martino Название: High Performance Computational Methods for Biological Sequence Analysis ISBN: 1461286026 ISBN-13(EAN): 9781461286028 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: High Performance Computational Methods for Biological Sequence Analysis presents biological sequence analysis using an interdisciplinary approach that integrates biological, mathematical and computational concepts.
Описание: The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA's ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods, expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics.
Автор: K. Gardiner; U. Hochgeschwender Название: Identification of Transcribed Sequences ISBN: 1461360943 ISBN-13(EAN): 9781461360940 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The Human Genome Project, an endeavor to map and sequence the entire human genome, has been in existence for almost seven years. This latter endeavor represents a new facet of the genome project, and as such requires the recognition and solution of a new set of problems, with the attendant development and application of a new set of techniques.
Автор: Volker A. Erdmann; Jan Barciszewski Название: From Nucleic Acids Sequences to Molecular Medicine ISBN: 364243083X ISBN-13(EAN): 9783642430831 Издательство: Springer Рейтинг: Цена: 28732.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Written by leading experts in the field , this book covers hot topics such as small interference RNAs for gene silencing in molecular biology and medicine. Includes numerous illustrations.
Автор: Nadav Ahituv Название: Gene Regulatory Sequences and Human Disease ISBN: 1489987851 ISBN-13(EAN): 9781489987853 Издательство: Springer Рейтинг: Цена: 26120.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book reviews breakthroughs in genomics that have led to new understanding of the effect of gene regulatory sequences in disease. Includes examples of nucleotide variants in noncoding sequences that have been shown to be associated with human diseases.
Автор: David Posada Название: Bioinformatics for DNA Sequence Analysis ISBN: 1617378399 ISBN-13(EAN): 9781617378393 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In Bioinformatics for DNA Sequence Analysis, experts provide practical guidance and troubleshooting advice for the computational analysis of DNA sequences, covering a range of issues and methods that demonstrate the vital relevance bioinformatics has today.
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