Описание: The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA's ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods, expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics.
Описание: This book covers application of graph theory for efficient analysis; the force method extended to finite element analysis; meta-heuristic algorithms applied to ordering; efficient use of symmetry and regularity in structural analysis by force method; and more.
Автор: Nikolay V Dokholyan Название: Computational Modeling of Biological Systems ISBN: 1489987509 ISBN-13(EAN): 9781489987501 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides an overview of emerging computational methods for modeling biologically and medically relevant systems. The book describes multiple methods for modeling, visualizing and rationally altering systems at various length scales.
Автор: Walter Rocchia; Michela Spagnuolo Название: Computational Electrostatics for Biological Applications ISBN: 3319379348 ISBN-13(EAN): 9783319379340 Издательство: Springer Рейтинг: Цена: 18284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents established and new approaches to perform calculations of electrostatic interactions at the nanoscale, with particular focus on molecular biology applications.
Автор: David Posada Название: Bioinformatics for DNA Sequence Analysis ISBN: 1617378399 ISBN-13(EAN): 9781617378393 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In Bioinformatics for DNA Sequence Analysis, experts provide practical guidance and troubleshooting advice for the computational analysis of DNA sequences, covering a range of issues and methods that demonstrate the vital relevance bioinformatics has today.
Автор: Reijer Idema; Domenico J.P. Lahaye Название: Computational Methods in Power System Analysis ISBN: 9462390630 ISBN-13(EAN): 9789462390638 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With sections handling the latest computational methods, mathematical concepts, power flow, and contingency analysis, this volume`s integrated treatment of the subject prepares technicians and engineers for the large and complex power systems of the future.
Описание: This work focuses on proteins and their structures, protein structure similarity searching at main representation levels and various techniques that can be used to accelerate similarity searches.
Автор: Michel Dayd?; Osni Marques; Kengo Nakajima Название: High Performance Computing for Computational Science -- VECPAR 2014 ISBN: 3319173529 ISBN-13(EAN): 9783319173528 Издательство: Springer Рейтинг: Цена: 7826.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book constitutes the thoroughly refereed post-conference proceedings of the 11th International Conference on High Performance Computing for Computational Science, VECPAR 2014, held in Eugene, OR, USA, in June/July 2014.
Автор: Walter Rocchia; Michela Spagnuolo Название: Computational Electrostatics for Biological Applications ISBN: 331912210X ISBN-13(EAN): 9783319122106 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents established and new approaches to perform calculations of electrostatic interactions at the nanoscale, with particular focus on molecular biology applications. It is based on the proceedings of the Computational Electrostatics for Biological Applications international meeting, which brought together researchers in computational disciplines to discuss and explore diverse methods to improve electrostatic calculations. Fostering an interdisciplinary approach to the description of complex physical and biological problems, this book encompasses contributions originating in the fields of geometry processing, shape modeling, applied mathematics, and computational biology and chemistry. The main topics covered are theoretical and numerical aspects of the solution of the Poisson-Boltzmann equation, surveys and comparison among geometric approaches to the modelling of molecular surfaces and related discretization and computational issues. It also includes a number of contributions addressing applications in biology, biophysics and nanotechnology. The book is primarily intended as a reference for researchers in the computational molecular biology and chemistry fields. As such, it also aims at becoming a key source of information for a wide range of scientists who need to know how modeling and computing at the molecular level may influence the design and interpretation of their experiments.
Автор: Richard Durrett Название: Probability Models for DNA Sequence Evolution ISBN: 1441926771 ISBN-13(EAN): 9781441926777 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In approaching this question a number of probability models are introduced and anyalyzed.Throughout the book, the theory is developed in close connection with data from more than 60 experimental studies that illustrate the use of these results.
Описание: The introduction of Next Generation Sequencing (NGS) technologies resulted in a major transformation in the way scientists extract genetic information from biological systems, revealing limitless insight about the genome, transcriptome and epigenome of any species. However, with NGS, came its own challenges that require continuous development in the sequencing technologies and bioinformatics analysis of the resultant raw data and assembly of the full length genome and transcriptome. Such developments lead to outstanding improvements of the performance and coverage of sequencing and improved quality for the assembled sequences, nevertheless, challenges such as sequencing errors, expensive processing and memory usage for assembly and sequencer specific errors remains major challenges in the field. This book aims to provide brief overviews the NGS field with special focus on the challenges facing the NGS field, including information on different experimental platforms, assembly algorithms and software tools, assembly error correction approaches and the correlated challenges.
Автор: John Parkinson Название: Expressed Sequence Tags (ESTs) ISBN: 1617377600 ISBN-13(EAN): 9781617377600 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Leading experts in the field introduce the reader to many of the fundamental concepts underlying the generation and analysis of ESTs through accessible and affordable sequencing technologies. The book includes reproducible protocols and troubleshooting advice.
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