Excitatory-Inhibitory Balance, Takao K. Hensch; Michela Fagiolini

Автор: Satya Prakash Gupta
Название: Matrix Metalloproteinase Inhibitors
ISBN: 3034807643 ISBN-13(EAN): 9783034807647
Издательство: Springer
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Описание: MMPs are involved in numerous biological processes, fostering tissue degradation resulting in pathologies from osteoarthritis to tumor metastasis. This book focuses on the latest quantitative research into the endogenous inhibitors that disrupt MMP activity.

Автор: T. Kato; W. Kr?mer; K.-H. Kuck; D.M. Norris; H. Sc
Название: Sterol Biosynthesis Inhibitors and Anti-Feeding Compounds
ISBN: 3642697925 ISBN-13(EAN): 9783642697920
Издательство: Springer
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Описание: Living organisms are separated from the outside world by their membranes, which perform important roles for maintaining their lives. Sterols are indispensable com- ponents in eukaryotic organisms for stabilizing membranes composed of phospho- lipid bilayers. Most prokaryotic organisms, on the other hand, do not contain sterols in their membranes, although recent studies indicated that the bacterium Methylo- coccus capsulatus produces sterols 1) and many strains of Mycoplasma, bacteria without cell walls, require sterols as an essential growth factor 2). Some bacterial species synthesize hopanoids which are hypothesized to function like st rols in eu- karyotic organisms 3). Significance of ergosterol in fungi has been recognized from the fact that the yeast Saccharomyces cerevisiae requires ergosterol for growth, when cultured in a strictly anaerobic condition "'. l: .lectron microscopic studies showed that membrane structures disappeared in the yeast grown anaerobically without a supplement of ergosterol 5.6), indicating the necessity of ergosterol for membrane biogenesis. Further confirmation of the significant role of ergosterol in the membranes was derived from the studies on polyene antibiotics. In the presence of polyenes such as nystatin, filipin and amphotericin B, fungal cells lose selective permeability of the membranes, since polyenes interact with ergosterol, such that the structure of the fungal membranes is disrupted 7).

Автор: Louis M. Aledort; Leon W. Hoyer; Jeanne M. Lusher;
Название: Inhibitors to Coagulation Factors
ISBN: 1461380014 ISBN-13(EAN): 9781461380016
Издательство: Springer
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Цена: 12157.00 р.
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Описание: Proceedings of the Second International Symposium held in Chapel Hill, North Carolina, November 3-5, 1993

Автор: V. Kefeli; Bruno Borsari; M.V. Kalevitch
Название: Natural Growth Inhibitors and Phytohormones in Plants and Environment
ISBN: 9048161983 ISBN-13(EAN): 9789048161980
Издательство: Springer
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Цена: 26120.00 р.
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Описание: Therefore, this effort proposes a more holistic approach to the study of plant physiology, in which the plant-soil interactions are discussed, with a profound description of different allelochemicals and their effects on plants growth.

Название: Viral proteases and their inhibitors
ISBN: 0128097124 ISBN-13(EAN): 9780128097120
Издательство: Elsevier Science
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Цена: 15831.00 р.
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Описание: Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.

Автор: Takao K. Hensch; Michela Fagiolini
Название: Excitatory-Inhibitory Balance
ISBN: 0306479621 ISBN-13(EAN): 9780306479625
Издательство: Springer
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Цена: 26122.00 р.
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Описание: Aims to provide an integrated view of neuron function, operating in a balanced regime of excitation and inhibition. Emphasizing how this balance is established, maintained, and modified from the molecular to system levels, this book is useful for advanced graduate students, post-docs, and faculty.

Автор: Melanie A. Woodin; Arianna Maffei
Название: Inhibitory Synaptic Plasticity
ISBN: 1489981276 ISBN-13(EAN): 9781489981271
Издательство: Springer
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Цена: 27950.00 р.
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Описание: This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug addiction and in neuropathology. Inhibitory Synaptic Plasticity will be of particular interest to neuroscientists and neurophysiologists.

Автор: D. Vazquez
Название: Inhibitors of Protein Biosynthesis
ISBN: 3642813119 ISBN-13(EAN): 9783642813115
Издательство: Springer
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Автор: Theodor B?cher; H. Sies
Название: Inhibitors Tools in Cell Research
ISBN: 3540044418 ISBN-13(EAN): 9783540044413
Издательство: Springer
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Описание: The scope of the 20th Mosbach Colloquium may be best illustrated by the following notes sent to the speakers when the colloquium was organized. 2) At this colloquium we want to contribute illustrations of the useful application of inhibitors to biological problems.

Автор: Yehezkel Ben-Ari
Название: Excitatory Amino Acids and Neuronal Plasticity
ISBN: 1468457713 ISBN-13(EAN): 9781468457711
Издательство: Springer
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Описание: Proceedings of the European Neuroscience Association Satellite Symposium held in Fillerval, France, August 27-31, 1989

Автор: Sarah L. Pallas
Название: Developmental Plasticity of Inhibitory Circuitry
ISBN: 1489982833 ISBN-13(EAN): 9781489982834
Издательство: Springer
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Описание: Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. Experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging. The book brings together the work of researchers investigating inhibitory plasticity at many levels of analysis and in several different preparations. This topic is of wide relevance across a number of different areas of research in neuroscience and neurology. Medical problems such as epilepsy, mental illness, drug abuse, and movement disorders can result from malfunctioning inhibitory circuits. Further, the maturation of inhibitory circuits may trigger the onset of critical periods of neural circuit plasticity, raising the possibility that such plastici periods could be reactivated for medical benefit by manipulating inhibitory circuitry.