Описание: The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases.There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.
Автор: Kelly Anne Hyndman; Thomas L. Pannabecker Название: Sodium and Water Homeostasis ISBN: 1493932128 ISBN-13(EAN): 9781493932122 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture. Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance.
Автор: Banfalvi Gaspar Название: Homeostasis - Tumor - Metastasis ISBN: 940077334X ISBN-13(EAN): 9789400773349 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explains how lifestyle, environment, genetic makeup and social conditions can help maintain or upset the biological balance and lead to cancer. Cover tumor formation as well as mestasis, the spread of tumor cells to distant parts of the organism.
Автор: Yuzuru Ishimura; Hideo Shimada; Makoto Suematsu Название: Oxygen Homeostasis and Its Dynamics ISBN: 4431702024 ISBN-13(EAN): 9784431702023 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This first volume in a projected series contains the proceedings of the first of the Keio University International Symposia for Life Sciences and Medicine under the sponsorship of the Keio University Medical Science Fund.
Автор: Ingrid C. Gelissen; Andrew J. Brown Название: Cholesterol Homeostasis ISBN: 1493968734 ISBN-13(EAN): 9781493968732 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides state-of-the-art techniques for studying various aspects of cholesterol homeostasis, including its uptake, synthesis and efflux from the cell, as well as its trafficking within the cell.
Автор: Keith Schillo Название: Human Anatomy and Physiology: Form, Function, and Homeostasis ISBN: 151652957X ISBN-13(EAN): 9781516529575 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 27582.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Human Anatomy and Physiology: Form, Function, and Homeostasis helps students understand the human body in terms of the structures and functions of various body systems. Clear and concise, the selected material provides descriptions of how major organ systems, individual organs, tissues, and cells interact to maintain homeostasis. The text establishes a conceptual framework for studying anatomy and physiology at the molecular, cellular, and systematic levels. The major chapters of the text include the integumentary, skeletal, muscular, nervous, endocrine, cardiovascular, respiratory, digestive, urinary, and reproductive systems. Chapters that focus on physiology begin with case studies that highlight major concepts and progress to discussions of the major processes that regulate homeostasis. All chapters include a list of learning outcomes that are aligned with a collection of study questions. Many standard texts provide more information than can be covered, even in a standard, two-course progression. Human Anatomy and Physiology streamlines information and focuses on the most important aspects of human form and function in a no-frills, non-intimidating manner. The book is specifically designed for standard two-course sequences in anatomy and physiology, and is best suited to students who have completed a semester of biology.
Автор: Gaspar Banfalvi Название: Homeostasis - Tumor - Metastasis ISBN: 9402402489 ISBN-13(EAN): 9789402402483 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explains how lifestyle, environment, genetic makeup and social conditions can help maintain or upset the biological balance and lead to cancer. Cover tumor formation as well as mestasis, the spread of tumor cells to distant parts of the organism.
Автор: Yuzuru Ishimura; Hideo Shimada; Makoto Suematsu Название: Oxygen Homeostasis and Its Dynamics ISBN: 4431684786 ISBN-13(EAN): 9784431684787 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This first volume in a projected series contains the proceedings of the first of the Keio University International Symposia for Life Sciences and Medicine under the sponsorship of the Keio University Medical Science Fund.
Автор: Alfred Locker Название: Biogenesis Evolution Homeostasis ISBN: 3540061347 ISBN-13(EAN): 9783540061342 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In 1963, 1965 and 1967 "Symposia on Quantitative Biology of Metabolism" were organized on the pretty island of Helgoland (Biologische Anstalt) by me in col- laboration with O.
Автор: D.H. Wang Название: Molecular Sensors for Cardiovascular Homeostasis ISBN: 1489991999 ISBN-13(EAN): 9781489991997 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Biological homeostasis is maintained via intact function of an array of molecules detecting changes of microenvironments inside and outside of the biological system. These molecules, including cell membrane proteins and ion channels, are intimately involved in a variety of sensory pathways and respond to environmental stimuli, including altered temperature, pH, mechanical and osmotic stress, intra- and extracellular messengers, as well as changes in energy consumption. The book reveals the state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases. This work offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.
Автор: Joan Stein-Streilein Название: Infection, Immune Homeostasis and Immune Privilege ISBN: 303480797X ISBN-13(EAN): 9783034807975 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.
Автор: Danielle Pansu; Felix Bronner Название: Calcium Transport and Intracellular Calcium Homeostasis ISBN: 3642839797 ISBN-13(EAN): 9783642839795 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Research Workshop on Calcium Transport and Intracellular Calcium Homeostasis held in Lyon, France, March 4-7, 1990
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