Автор: Joan Stein-Streilein Название: Infection, Immune Homeostasis and Immune Privilege ISBN: 303480797X ISBN-13(EAN): 9783034807975 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.
Описание: The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases.There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.
Автор: Kelly Anne Hyndman; Thomas L. Pannabecker Название: Sodium and Water Homeostasis ISBN: 1493932128 ISBN-13(EAN): 9781493932122 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture. Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance.
Автор: Banfalvi Gaspar Название: Homeostasis - Tumor - Metastasis ISBN: 940077334X ISBN-13(EAN): 9789400773349 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explains how lifestyle, environment, genetic makeup and social conditions can help maintain or upset the biological balance and lead to cancer. Cover tumor formation as well as mestasis, the spread of tumor cells to distant parts of the organism.
Автор: Yuzuru Ishimura; Hideo Shimada; Makoto Suematsu Название: Oxygen Homeostasis and Its Dynamics ISBN: 4431684786 ISBN-13(EAN): 9784431684787 Издательство: Springer Рейтинг: Цена: 12157.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This first volume in a projected series contains the proceedings of the first of the Keio University International Symposia for Life Sciences and Medicine under the sponsorship of the Keio University Medical Science Fund.
Автор: Jen-Tsan Ashley Chi Название: Molecular Genetics of Dysregulated pH Homeostasis ISBN: 1493916823 ISBN-13(EAN): 9781493916825 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases.
Автор: E. Carafoli; J. Krebs Название: Calcium Homeostasis ISBN: 3642635326 ISBN-13(EAN): 9783642635328 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With contributions by numerous experts
Автор: Sidney Donald Bradshaw Название: Homeostasis in Desert Reptiles ISBN: 364264368X ISBN-13(EAN): 9783642643682 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Deserts, whether hot or cold, are considered to be one of the most difficult environments for living systems, lacking the essential free water which ac- counts for approximately 60-70% of their body mass and more than 98% of their constituent atoms {Macfarlane 1978}.
Автор: Susanne Sattler; Teresa Kennedy-Lydon Название: The Immunology of Cardiovascular Homeostasis and Pathology ISBN: 3319576119 ISBN-13(EAN): 9783319576114 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Preface Introduction Section 1: The Immune system in tissue and organ homeostasis Chapter 1: The Immune system beyond the fight against infection Section 2: Immune functions and properties of resident cells in the heart and cardiovascular system Chapter 2: Cardiomyocytes: Paying for the Tolls - The High Cost of the Innate Immune System for the Cardiac Myocyte Chapter 3: Fibroblasts: Properties and immune function of cardiac fibroblasts Chapter 4: Endothelial cells Chapter 5: Pericytes Chapter 6: Tissue-resident macrophages: The role of cardiac tissue macrophages in homeostasis and disease Section 3: The immune system in cardiovascular pathology Chapter 7: Atherosclerosis Chapter 8: Immune mediated heart disease Chapter 9: Vasculitis in the central nervous system Chapter 10: Cardiac Autoimmunity: Myocarditis Section 4: The immune system in repair and regeneration after myocardial infarct Chapter 11: Lymphocytes at the heart of wound healing Chapter 12: The innate immune system in cardiovascular repair and regeneration
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