The Immunology of Cardiovascular Homeostasis and Pathology, Susanne Sattler; Teresa Kennedy-Lydon

Автор: Jen-Tsan Ashley Chi
Название: Molecular Genetics of Dysregulated pH Homeostasis
ISBN: 1493916823 ISBN-13(EAN): 9781493916825
Издательство: Springer
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Цена: 13974.00 р.
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Описание: Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases.

Автор: Banfalvi Gaspar
Название: Homeostasis - Tumor - Metastasis
ISBN: 940077334X ISBN-13(EAN): 9789400773349
Издательство: Springer
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Цена: 23508.00 р.
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Описание: This book explains how lifestyle, environment, genetic makeup and social conditions can help maintain or upset the biological balance and lead to cancer. Cover tumor formation as well as mestasis, the spread of tumor cells to distant parts of the organism.

Автор: D.H. Wang
Название: Molecular Sensors for Cardiovascular Homeostasis
ISBN: 1489991999 ISBN-13(EAN): 9781489991997
Издательство: Springer
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Цена: 22359.00 р.
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Описание: Biological homeostasis is maintained via intact function of an array of molecules detecting changes of microenvironments inside and outside of the biological system. These molecules, including cell membrane proteins and ion channels, are intimately involved in a variety of sensory pathways and respond to environmental stimuli, including altered temperature, pH, mechanical and osmotic stress, intra- and extracellular messengers, as well as changes in energy consumption. The book reveals the state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases. This work offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.

Автор: Jen-Tsan Ashley Chi
Название: Molecular Genetics of Dysregulated pH Homeostasis
ISBN: 1493953176 ISBN-13(EAN): 9781493953172
Издательство: Springer
Рейтинг:
Цена: 13974.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases.

Автор: Andrew L. Snow; Michael J. Lenardo
Название: Immune Homeostasis
ISBN: 1493959689 ISBN-13(EAN): 9781493959686
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This book examines experimental techniques for measuring and analyzing immune cell dynamics, with an emphasizes lymphocyte programmed cell deaths in different contexts. It features expert tips and key implementation advice to guarantee successful results.

Автор: Nektarios Tavernarakis
Название: Protein Metabolism and Homeostasis in Aging
ISBN: 1489979395 ISBN-13(EAN): 9781489979391
Издательство: Springer
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Цена: 26120.00 р.
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Описание: This book examines the role of protein metabolism and homeostasis in aging. It offers an overview of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, and degradation and turnover.

Автор: Joan Stein-Streilein
Название: Infection, Immune Homeostasis and Immune Privilege
ISBN: 303480797X ISBN-13(EAN): 9783034807975
Издательство: Springer
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Цена: 23757.00 р.
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Описание: Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.

Автор: E. Carafoli; J. Krebs
Название: Calcium Homeostasis
ISBN: 3642635326 ISBN-13(EAN): 9783642635328
Издательство: Springer
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Цена: 15672.00 р.
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Описание: With contributions by numerous experts

Автор: T. Godfraind; G. Mancia; M.P. Abbracchio; L. Aguil
Название: Pharmacological Control of Calcium and Potassium Homeostasis
ISBN: 9401040567 ISBN-13(EAN): 9789401040563
Издательство: Springer
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Цена: 20962.00 р.
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Описание: As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. Calcium homeostasis within the cell is not only regulated by calcium channels;

Автор: Gaspar Banfalvi
Название: Homeostasis - Tumor - Metastasis
ISBN: 9402402489 ISBN-13(EAN): 9789402402483
Издательство: Springer
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Цена: 19589.00 р.
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Описание: This book explains how lifestyle, environment, genetic makeup and social conditions can help maintain or upset the biological balance and lead to cancer. Cover tumor formation as well as mestasis, the spread of tumor cells to distant parts of the organism.

Автор: Richard Bucala; J?rgen Bernhagen
Название: MIF Family Cytokines in Innate Immunity and Homeostasis
ISBN: 331952352X ISBN-13(EAN): 9783319523521
Издательство: Springer
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Цена: 22359.00 р.
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Описание: The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established.

Автор: T. Godfraind; G. Mancia; M.P. Abbracchio; L. Aguil
Название: Pharmacological Control of Calcium and Potassium Homeostasis
ISBN: 0792336046 ISBN-13(EAN): 9780792336044
Издательство: Springer
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Цена: 30606.00 р.
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Описание: Gives a treatment of calcium and potassium channel pharmacology. This work first presents both molecular and preclinical pharmacology data, followed by contributions on the clinical application of the drugs that modulate calcium and potassium channels. It also includes chapters that discuss possible roles and application to the nervous system.