Molecular Genetics of Dysregulated pH Homeostasis, Jen-Tsan Ashley Chi

Автор: Susanne Sattler; Teresa Kennedy-Lydon
Название: The Immunology of Cardiovascular Homeostasis and Pathology
ISBN: 3319576119 ISBN-13(EAN): 9783319576114
Издательство: Springer
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Описание: Preface
Introduction
Section 1: The Immune system in tissue and organ homeostasis
Chapter 1: The Immune system beyond the fight against infection
Section 2: Immune functions and properties of resident cells in the heart and cardiovascular system
Chapter 2: Cardiomyocytes: Paying for the Tolls - The High Cost of the Innate Immune System for the Cardiac Myocyte
Chapter 3: Fibroblasts: Properties and immune function of cardiac fibroblasts
Chapter 4: Endothelial cells
Chapter 5: Pericytes
Chapter 6: Tissue-resident macrophages: The role of cardiac tissue macrophages in homeostasis and disease
Section 3: The immune system in cardiovascular pathology
Chapter 7: Atherosclerosis
Chapter 8: Immune mediated heart disease
Chapter 9: Vasculitis in the central nervous system
Chapter 10: Cardiac Autoimmunity: Myocarditis
Section 4: The immune system in repair and regeneration after myocardial infarct
Chapter 11: Lymphocytes at the heart of wound healing
Chapter 12: The innate immune system in cardiovascular repair and regeneration
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Автор: Jen-Tsan Ashley Chi
Название: Molecular Genetics of Dysregulated pH Homeostasis
ISBN: 1493916823 ISBN-13(EAN): 9781493916825
Издательство: Springer
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Описание: Most biological reactions and functions occur within a narrow range of pH. Any changes in the pH have great impacts on the biological functional at every level, including protein folding, enzymatic activities and proliferation and cell death. Therefore, maintain the pH homeostasis at the local or systemic level is one of the highest priorities for all multicellular organisms. Many redundant mechanisms are in place to maintain the pH homeostasis, a topic that is well covered in the scientific literature and medical textbooks. However, when the pH homeostasis is disrupted in various physiological adaptations and pathological situations, resulting acidity may trigger significant pathophysiological events and modulate disease outcomes. Therefore, understanding how various cells sense and react to acidity have broad impact in a wide variety of human diseases, including cancer, stroke, myocardial infarction and diabetes, renal and infectious diseases. In this book, many investigators have summarized the molecular genetics on the detailed mechanisms by which different mammalian cells sense and response acidity. These chapters cover the acidity with broad impact in biological understanding and human diseases and review various sensing mechanism and cellular responses to pH alterations in both physiological (taste, pain) and pathological settings (ischemia and cancers). Furthermore, these authors present a broad spectrum of investigative approaches to cellular response to acidosis in a in wide variety of human diseases.

Автор: Gaspar Banfalvi
Название: Homeostasis - Tumor - Metastasis
ISBN: 9402402489 ISBN-13(EAN): 9789402402483
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Описание: This book explains how lifestyle, environment, genetic makeup and social conditions can help maintain or upset the biological balance and lead to cancer. Cover tumor formation as well as mestasis, the spread of tumor cells to distant parts of the organism.

Автор: Alfred Locker
Название: Biogenesis Evolution Homeostasis
ISBN: 3540061347 ISBN-13(EAN): 9783540061342
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Описание: In 1963, 1965 and 1967 "Symposia on Quantitative Biology of Metabolism" were organized on the pretty island of Helgoland (Biologische Anstalt) by me in col- laboration with O.

Автор: Joan Stein-Streilein
Название: Infection, Immune Homeostasis and Immune Privilege
ISBN: 303480797X ISBN-13(EAN): 9783034807975
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Описание: Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.

Автор: Yuzuru Ishimura; Hideo Shimada; Makoto Suematsu
Название: Oxygen Homeostasis and Its Dynamics
ISBN: 4431684786 ISBN-13(EAN): 9784431684787
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Описание: This first volume in a projected series contains the proceedings of the first of the Keio University International Symposia for Life Sciences and Medicine under the sponsorship of the Keio University Medical Science Fund.

Автор: Richard Bucala; J?rgen Bernhagen
Название: MIF Family Cytokines in Innate Immunity and Homeostasis
ISBN: 331952352X ISBN-13(EAN): 9783319523521
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Описание: The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established.

Автор: E. Carafoli; J. Krebs
Название: Calcium Homeostasis
ISBN: 3642635326 ISBN-13(EAN): 9783642635328
Издательство: Springer
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Описание: With contributions by numerous experts

Автор: Banfalvi Gaspar
Название: Homeostasis - Tumor - Metastasis
ISBN: 940077334X ISBN-13(EAN): 9789400773349
Издательство: Springer
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Описание: This book explains how lifestyle, environment, genetic makeup and social conditions can help maintain or upset the biological balance and lead to cancer. Cover tumor formation as well as mestasis, the spread of tumor cells to distant parts of the organism.

Автор: D.H. Wang
Название: Molecular Sensors for Cardiovascular Homeostasis
ISBN: 1489991999 ISBN-13(EAN): 9781489991997
Издательство: Springer
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Описание: Biological homeostasis is maintained via intact function of an array of molecules detecting changes of microenvironments inside and outside of the biological system. These molecules, including cell membrane proteins and ion channels, are intimately involved in a variety of sensory pathways and respond to environmental stimuli, including altered temperature, pH, mechanical and osmotic stress, intra- and extracellular messengers, as well as changes in energy consumption. The book reveals the state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases. This work offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.

Автор: Nektarios Tavernarakis
Название: Protein Metabolism and Homeostasis in Aging
ISBN: 1489979395 ISBN-13(EAN): 9781489979391
Издательство: Springer
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Описание: This book examines the role of protein metabolism and homeostasis in aging. It offers an overview of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, and degradation and turnover.

Автор: Ingrid C. Gelissen; Andrew J. Brown
Название: Cholesterol Homeostasis
ISBN: 1493968734 ISBN-13(EAN): 9781493968732
Издательство: Springer
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Описание: This volume provides state-of-the-art techniques for studying various aspects of cholesterol homeostasis, including its uptake, synthesis and efflux from the cell, as well as its trafficking within the cell.