Bioinformatics and Drug Discovery, Richard S. Larson; Tudor I. Oprea
Автор: Loging William T. Название: Bioinformatics and Computational Biology in Drug Discovery a ISBN: 1108461158 ISBN-13(EAN): 9781108461153 Издательство: Cambridge Academ Рейтинг: Цена: 5702.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Providing a comprehensive overview of the drug discovery and development pipeline, this book focuses on the integral role that computational biology methods play in this process. Covering technological advances and their relation to drug developmental processes, readers are exposed to new methods of discovery utilising the available technology.
Автор: Larson Richard S. Название: Bioinformatics and Drug Discovery ISBN: 1588293467 ISBN-13(EAN): 9781588293466 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A collection of readily reproducible bioinformatic methods to advance the drug discovery process from gene identification to protein modeling to the identification of specific drug candidates. The authors demonstrate these techniques, including microarray analysis, the analysis of genes as potential drug targets, virtual screening and in silico protein design, and cheminformatics, in a variety of practical situations. Because these technologies are still emergent, each chapter contains an extended introduction that explains the theory and application of the technology and techniques described.
Описание: Providing a comprehensive overview of the drug discovery and development pipeline, this book focuses on the integral role that computational biology methods play in this process. Covering technological advances and their relation to drug developmental processes, readers are exposed to new methods of discovery utilising the available technology.
Автор: Wadhwa, Gulshan. Название: Current trends in bioinformatics : ISBN: 981107481X ISBN-13(EAN): 9789811074813 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: This book highlights the latest breakthrough developments in bioinformatics. It presents a series of timely, in-depth reviews, drug clinical trial studies, biodiversity informatics and thematic issues. In addition, it includes insightful reviews on advances in computational molecular/structural biology, which address areas such as computing in biomedicine and genomics, computational proteomics and systems biology, and metabolic pathway engineering. Innovations in these fields have direct impacts on key issues related to healthcare, medicine, genetic disorders, the development of agricultural products, renewable energy, and environmental protection. Written by respected leaders in the field and covering a wide range of topics involving the integration of biology with computer and information science, the book offers an ideal basis for teaching at the undergraduate and graduate levels. It can also be used for self-instruction by research investigators interested in applying bioinformatics-based analytical methods and information technologists working with academic and industrial laboratories.
Автор: Forsdyke, Donald R. Название: Evolutionary bioinformatics / ISBN: 3319287532 ISBN-13(EAN): 9783319287539 Издательство: Springer Рейтинг: Цена: 26552.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Now in its third edition and supplemented with more online material, this book aims to make the "new" information-based (rather than gene-based) bioinformatics intelligible both to the "bio" people and the "info" people.
Автор: David Posada Название: Bioinformatics for DNA Sequence Analysis ISBN: 1617378399 ISBN-13(EAN): 9781617378393 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In Bioinformatics for DNA Sequence Analysis, experts provide practical guidance and troubleshooting advice for the computational analysis of DNA sequences, covering a range of issues and methods that demonstrate the vital relevance bioinformatics has today.
Автор: Ronald J.A. Trent Название: Clinical Bioinformatics ISBN: 1617377813 ISBN-13(EAN): 9781617377815 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: With the ever-increasing volume of information in clinical medicine, researchers and health professionals need computer-based storage, processing and dissemination. In this book, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance.
This book reviews the advances and challenges of structure-based drug design in the preclinical drug discovery process, addressing various diseases, including malaria, tuberculosis and cancer. Written by internationally recognized researchers, this edited book discusses how the application of the various in-silico techniques, such as molecular docking, virtual screening, pharmacophore modeling, molecular dynamics simulations, and residue interaction networks offers insights into pharmacologically active novel molecular entities. It presents a clear concept of the molecular mechanism of different drug targets and explores methods to help understand drug resistance. In addition, it includes chapters dedicated to natural-product- derived medicines, combinatorial drug discovery, the CryoEM technique for structure-based drug design and big data in drug discovery.
The book offers an invaluable resource for graduate and postgraduate students, as well as for researchers in academic and industrial laboratories working in the areas of chemoinformatics, medicinal and pharmaceutical chemistry and pharmacoinformatics.
Автор: Andrei L. Osterman; Svetlana Y. Gerdes Название: Microbial Gene Essentiality: Protocols and Bioinformatics ISBN: 1617375292 ISBN-13(EAN): 9781617375293 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book contains a comprehensive collection of experimental and computational strategies and techniques for microbial genome-scale essentiality studies, developed and presented by the leading groups in the field. It contains detailed description of the procedures, discussion of potential difficulties and failures.
Introduction.- Review of Literature.- Materials and Methods (Tools and Databases).- Flowchart.- Conclusion.-References.
Название: Companion diagnostics (cdx) in precision medicine ISBN: 9814800236 ISBN-13(EAN): 9789814800235 Издательство: Taylor&Francis Рейтинг: Цена: 17762.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book covers the technical, historical, clinical, and regulatory aspects of CDx in precision medicine. Clearly, more and more newly developed oncology drugs will require accompanying CDx assays, and this book, with chapters contributed by renowned oncologists.
Автор: Mias Название: Mathematica for Bioinformatics ISBN: 3319723766 ISBN-13(EAN): 9783319723761 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1 Introduction to Bioinformatics
1.1 Principles of Genomics
1.2 Beyond the Genomes: Multiple Omics
1.3 Systems and Networks
1.4 Bioinformatics in modern genetics
2. A Mathematica Primer for Bioinformaticians
2.1 Getting Started
2.2 Variables
2.3 Lists
2.4 Functions
2.4 Importing and Exporting Data
2.5 Graphics
2.6 Associations and Query
2.7 Wolfram Alpha
2.8 Wolfram Language Resources
3. Statistics for Genomic Analysis
3.1 Probability
3.2 Distributions
3.3 Hypotheses
3.4 Parametric Testing
3.5 Non-parametric Testing
3.6 Markov Chains
3.7 Exploratory Data Analysis
4. Genomic Sequences
4.1 Sequence Alignments
4.2 Pairwise Alignment
4.3 Dynamic Programming
4.4 Processing Sequencing Files
5. Databases
5.1 Connecting to Databases
5.2 UCSC Browser and MySQL
5.3 Gene Ontology Annotations
5.4 Biological Pathways
5.5 Genomic Medicine Data Sources
6. Transcriptomics
6.1 Transcriptomic Data
6.2 Quality Control
6.3 Normalization
6.4 Differential Gene Expression
6.5 Visualization
6.6 Classification and Biological Significance
7. Proteomics
7.1 Proteomics Data
7.2 Spectral Visualization
7.3 Quality Control
7.4 Normalization
7.5 Differential Protein Expression
7.6 Visualization
8. Metabolomics
8.1 Metabolomics Data
8.2 Metabolomics Databases
8.3 Metabolomics Data Analysis
8.4 Putative Identification of Compounds
8.5 Clustering and Principal Co
mponents Analysis
9. Systems Biology
9.1 Introduction to Systems Biology
9.2 Basic Models
9.3 Visualization of Data
9.4 Beyond Basic Models
10. Networks
10.1 Introduction to Network Analysis
10.2 Basic Network Construction
10.3 Network Properties
10.4 Network Comparison
10.5 Scale Free Networks
11. Time Series Analysis
11.1 Introduction to Time Series
11.2 Regularly Sampled Time Series
11.3 Frequency Representation of Longitudinal Data
11.4 Uneven Sampling
12. Omics Integration and Systems Medicine
12.1 Introduction to Multiple Omics Integration
12.2 Systems Medicine Approaches
12.3 Example Integration of Omics Datasets
13. Bioinformatics Development with Mathematica
13.1 Introduction to Pa
ckages
13.2 Creating a Simple Bioinformatics Package
13.3 Dynamics, Manipulate and Interactive Interfaces
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