Structure And Function Of The Extracellular Matrix, Suki, Bela

Автор: Zaccai, Nathan R. (University of Cambridge) Serdyuk, Igor N. Zaccai, Joseph
Название: Methods in Molecular Biophysics: Structure, Dynamics, Function for Biology and Medicine, 2 ed.
ISBN: 1107056373 ISBN-13(EAN): 9781107056374
Издательство: Cambridge Academ
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Описание: Reflecting the significant developments of the past decade, this textbook explains key physical methods in modern biology. Each method is illustrated through real-world examples, alongside background information designed for both physicists and biologists, making this an ideal resource for students in biophysics at science and medical schools.

Автор: Jennie B. Leach; Elizabeth M. Powell
Название: Extracellular Matrix
ISBN: 1493946870 ISBN-13(EAN): 9781493946877
Издательство: Springer
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Описание:

Part I: Native Tissue

1. Immunohistochemical Characterization of Brain Neural and Vascular Basement Membranes

Zhen Huang

2. The Use of Synaptic Basal Lamina and Its Components to Identify Sites of Recent Morphological Alterations at Mammalian Neuromuscular Junctions

Young il Lee and Yue Li

3. Perineuronal Nets: A Special Structure in the Central Nervous System Extracellular Matrix

Jessica C.F. Kwok, Simona Foscarin, and James W. Fawcett

Part II: In Vitro Models

4. Isolation of Perinatal Mouse Cerebral Cortical Astrocytes

Rolicia F. Martin and Elizabeth M. Powell

5. Techniques for Examining the Effect of Substratum Bound Proteoglycans on Neurite Outgrowth In Vitro

Justin A. Beller, Thomas M. Hering, and Diane M. Snow

6. High-Throughput Quantitative Assay for Analyzing Neurite Outgrowth on a Uniform Substratum: The Cell-Substratum Assay

Justin A. Beller, Thomas M. Hering, and Diane M. Snow

7. Extracellular Matrix Components as a Substrate for Outgrowing Motoneurons

Rebecca Conrad, Alice Klausmeyer, Teresa Tsai, Andreas Faissner, and Stefan Wiese

8. Replicating the In Vivo Environment: Organotypic and Submerged Three-Dimensional Culture Methods

Cйline Plachez and Elizabeth M. Powell

9. Culturing Neurons, Glia, and Progenitor Cells in Three-Dimensional Hydrogels

Swarnalatha Balasubramanian, Elizabeth M. Powell, and Jennie B. Leach

10. Investigating Cell-ECM Interactions and ECM Synthesis in Three-Dimensional Hydrogels

Swarnalatha Balasubramanian, Elizabeth M. Powell, and Jennie B. Leach

Part III: Injury, Degeneration, and Regeneration

11. Characterization and Analysis of Extracellular Matrix in Malignant Brain Tumors and Their Cellular Derivatives

Maksim Sinyuk, Justin D. Lathia, and Mariano S. Viapiano

12. Chondroitinase Gene Therapy for Spinal Cord Injury

Jianli Hu, Gabrielle M. Curinga, and George M. Smith

13. Modulation of Neural Stem Cell Expressed Extracellular Matrix (ECM) by Targeting Glycosyltransferases

Eva Hennen and Andreas Faissner

Part IV: Therapeutics and Engineered Systems

14. Evaluating the Spatial and Temporal Protein Production in Neural Tissue Engineering Constructs In Vitro

Caroline P. Addington, Christine Pauken, and Sarah E. Stabenfeldt

15. Cultivation and Imaging of Astrocytes on Protein-Coated Fluorescent Topographies Constructed from Aligned PLLA Electrospun Fibers

Jonathan M. Zuidema, Marнa C. Hyzinski-Garcнa, Alexander A. Mongin, and Ryan J. Gilbert

16. Engineered Microdevices to Study and Manipulate Neural Stem Cell Chemotaxis

Hui Xu and Sarah C. Heilshorn

17. Hydrolytically Degradable Polyethylene Glycol (PEG) Hydrogel: Synthesis, Gel Formation, and Characterization

Silviya Petrova Zustiak.

Автор: E.D. Hay
Название: Cell Biology of Extracellular Matrix
ISBN: 0306439514 ISBN-13(EAN): 9780306439513
Издательство: Springer
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Описание: Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Автор: Struther Arnott; D. A. Rees; E. R. Morris
Название: Molecular Biophysics of the Extracellular Matrix
ISBN: 0896030512 ISBN-13(EAN): 9780896030510
Издательство: Springer
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Описание: This work offers an interdisciplinary synthesis of what is currently known about the molecular architecture and properties of the complex biological milieux in which cells exist and function.

Автор: Struther Arnott; D. A. Rees; E. R. Morris
Название: Molecular Biophysics of the Extracellular Matrix
ISBN: 1461295939 ISBN-13(EAN): 9781461295938
Издательство: Springer
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Описание: Biopolymers, such as proteins and nucleic acids have been subjected to a rational succession of structural studies in which the determination of chemical compositions, link- ages, and sequences is followed by investigations of molecu- lar architecture and interactions. By the end of the 1960s the covalent structures of glycosaminoglycans and proteo- glycans had been defined both within the carbohydrate chains and in respect to their linkages to protein. The scene was therefore set for successful probing of three- dimensional shapes and intermolecular associations. For- tunately, during the 1970s appropriate physical methods were themselves greatly increasing in power. Consequently much progress has been made using X-ray diffraction anal- ysis of hydrated films, nuclear magnetic resonance spectro- scopy, and chromatographie methods for investigation of molecular interactions in solution. We now have a great deal of information about molecular shapes, their sensitiv- ity to environment (especially associated cations), and their modes of interaction that could be relevant to super- molecular assemblies in biological milieux. For these rea- sons we judged that it would be timely to distil the main conclusions from this phase of research to prepare for the next, which will involve detailed study of the interplay be- tween biological function and molecular structure. The idea for this volume emerged from a workshop meeting at Colworth sponsored by the Biochemical Society.

Автор: Schmuck
Название: Cardiac Extracellular Matrix
ISBN: 3319974203 ISBN-13(EAN): 9783319974200
Издательство: Springer
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Описание: This book on cardiac extracellular matrix (ECM) features three sections, Fundamental Science, Pre-Clinical and Translational Science, and Clinical Applications. In the Fundamental Science section, we will cover the spectrum of basic ECM science from ECM’s role in development, biomechanical properties, cardiac ECM influence of cardiomyocyte biology, pathophysiology of ECM in heart disease, and ECM in tissue engineering. Section two, Preclinical and Translational Science, will discuss cardiac ECM technologies in the clinical pipeline including approaches to ECM as a therapeutic, animal models of cardiac research, tracking and imaging methods of cardiac ECM, and cGMP manufacturing and regulatory considerations for ECM based therapeutics. Finally, the third section, Clinical Applications, will highlight the clinical experience around cardiac ECM including therapeutic strategies targeting scar tissue in the heart, Clinical trial design and regulatory considerations, current human clinical trials in cardiovascular medicine and the role of pharmaceutical and biotech companies in the commercialization of ECM technologies for cardiovascular indications. This book provides a comprehensive review for basic and translational researchers as well as clinical practitioners and those involved in commercialization, regulatory and entrepreneurial activities.

Автор: Nikos Karamanos
Название: Extracellular Matrix: Pathobiology and Signaling
ISBN: 3110258765 ISBN-13(EAN): 9783110258769
Издательство: Walter de Gruyter
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Описание: Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling.

Автор: Hudalla Gregory A., Murphy William L.
Название: Mimicking the Extracellular Matrix: The Intersection of Matrix Biology and Biomaterials
ISBN: 1839161485 ISBN-13(EAN): 9781839161483
Издательство: Royal Society of Chemistry
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Описание: Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

Автор: Yanhang Zhang
Название: Multi-scale Extracellular Matrix Mechanics and Mechanobiology
ISBN: 3030201813 ISBN-13(EAN): 9783030201814
Издательство: Springer
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Описание: This book describes the current state of knowledge in the field of multi-scale ECM mechanics and mechanobiology with a focus on experimental and modelling studies in biomechanical characterization, advanced optical microscopy and imaging, as well as computational modeling. This book also discusses the scale dependency of ECM mechanics, translation of mechanical forces from tissue to cellular level, and advances and challenges in improving our understanding of cellular mechanotransduction in the context of living tissues and organisms.

Автор: Litscher, Eveline
Название: Extracellular Matrix in Development
ISBN: 0128098023 ISBN-13(EAN): 9780128098028
Издательство: Elsevier Science
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Описание: Extracellular Matrix and Egg Coats, Volume 130, the latest release in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on The Human Egg’s Zona Pellucida, the Structure of Zona Pellucida Module Proteins, The Fish Egg’s Zona Pellucidam The Chicken Egg’s Zona Pellucidam The Marsupial Egg’s Zona Pellucida, the Evolution of Zona Pellucida Proteins, The Mouse Egg’s Zona Pellucida, Aspects of ECM, ECM and Morphogenesis, Collagen fibril assembly and function, The Ear's Tectorial Membrane, ECM and Cell Fate, and the Aspects of ECM.

Автор: Anna C. Berardi
Название: Extracellular Matrix for Tissue Engineering and Biomaterials
ISBN: 3319770217 ISBN-13(EAN): 9783319770215
Издательство: Springer
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Описание: This volume provides a state-of-art-report on the new methodologies in tissue engineering and developments in the biomaterials field based on the extracellular matrix-relevant discovery. Extracellular Matrix for Tissue Engineering and Biomaterials opens with an overview of the latest extracellular matrix research and in Part I, focuses on its biology and its role on cell behavior and cell fate relevant for the design of biomimetic surfaces. Part II details issues regarding the strategies currently applied in the research of biologically inspired materials and material systems for the replacement, repair and regeneration of tissues and organs. Part III presents the latest development methods applying knowledge from biology towards nanotechnology, to promote the restoration of the functionality of a living tissue. The book ranges from fundamental biology associated with tissue regeneration for the development of biomimetic approaches to controlling tissue formation, cell function, differentiation and angiogenesis using factors involved in normal tissue development and function. With the breadth and depth of the coverage of this topic, this book will serve as a valuable reference for anyone working in tissue engineering or biomaterials – from scientists, chemists and biologists through physicists, bioengineers and clinicians.

Автор: Evgenia Gerasimovskaya; Elzbieta Kaczmarek
Название: Extracellular ATP and adenosine as regulators of endothelial cell function
ISBN: 9400796803 ISBN-13(EAN): 9789400796805
Издательство: Springer
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Описание: This new book is uniquely focused on the signaling actions of extracellular purines in endothelial cells and the crucial role of extracellular purines in regulation of angiogenesis, vascular tone, cell permeability, wound healing, inflammation and cell-to-cell communication.