Single-Cell Sequencing and Methylation: Methods and Clinical Applications, Yu Buwei, Zhang Jiaqiang, Zeng Yiming
Автор: Urszula Demkow Название: Clinical Applications for Next Generation Sequencing ISBN: 0128017392 ISBN-13(EAN): 9780128017395 Издательство: Elsevier Science Рейтинг: Цена: 12462.00 р. Наличие на складе: Поставка под заказ.
Описание:
Clinical Applications for Next Generation Sequencing provides readers with an outstanding postgraduate resource to learn about the translational use of NGS in clinical environments.
Rooted in both medical genetics and clinical medicine, the book fills the gap between state-of-the-art technology and evidence-based practice, providing an educational opportunity for users to advance patient care by transferring NGS to the needs of real-world patients.
The book builds an interface between genetic laboratory staff and clinical health workers to not only improve communication, but also strengthen cooperation. Users will find valuable tactics they can use to build a systematic framework for understanding the role of NGS testing in both common and rare diseases and conditions, from prenatal care, like chromosomal abnormalities, up to advanced age problems like dementia.
Автор: Manel Esteller Название: DNA Methylation, Epigenetics and Metastasis ISBN: 9048169178 ISBN-13(EAN): 9789048169177 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: P.A. Jones; P.K. Vogt Название: DNA Methylation and Cancer ISBN: 3642640907 ISBN-13(EAN): 9783642640902 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is a comprehensive survey of new and exciting developments regarding the role of DNA methylation in human cancer.
Автор: Moshe Szyf Название: DNA Methylation and Cancer Therapy ISBN: 1441934162 ISBN-13(EAN): 9781441934161 Издательство: Springer Рейтинг: Цена: 32004.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation.
Автор: Atsushi Kaneda; Yu-ichi Tsukada Название: DNA and Histone Methylation as Cancer Targets ISBN: 3319597841 ISBN-13(EAN): 9783319597843 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This book will focus on DNA and histone methylation in epigenetics and describe how it is involved in the molecular mechanisms responsible for the development of cancer. Chapters will summarize the current knowledge of the molecular basis of DNA and histone methylation and explain how it is involved in cancer, describe the features of DNA and histone methylation associated with particular types of cancer, diagnostic/therapeutic applications, and future directions of DNA and histone methylation as cancer targets.
Автор: Alexandra Lusser Название: RNA Methylation ISBN: 149396805X ISBN-13(EAN): 9781493968053 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides a comprehensive collection of current methods and protocols to study posttranscriptional base modifications in RNA with special focus on methylation.
Автор: Kaneda Atsushi, Tsukada Yu-Ichi Название: DNA and Histone Methylation as Cancer Targets ISBN: 3319867008 ISBN-13(EAN): 9783319867007 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
DNA and histone methylation in epigenetics.- The molecular basis of DNA methylation.- The molecular basis of DNA demethylation.- DNA methylation changes in cancer.- Misregulation of DNA methylation regulators in cancer.- The molecular basis of histone methylation.- The molecular basis of histone demethylation.- Misregulation of histone methylation regulators in cancer.- Other histone modifications.- DNA methylation and dysregulation of miRNA in cancer.- Genomic imprinting syndromes and cancer.- DNA and Histone Methylation in Brain Cancer.- DNA and Histone Methylation in Gastric Cancer.- DNA and Histone Methylation in Hematopoietic malignancy.- DNA and Histone methylation in Lung cancer.- DNA and Histone Methylation in Liver Cancer.- DNA and Histone Methylation in Colon Cancer.- DNA and histone methylation in prostate cancer.- DNA and histone modifications in cancer diagnosis.- DNA and histone modifications in cancer therapy.- Future perspective of DNA and histone methylation as cancer targets.
Автор: Suzuki Название: Single Molecule and Single Cell Sequencing ISBN: 9811360367 ISBN-13(EAN): 9789811360367 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents an overview of the recent technologies in single molecule and single cell sequencing. New developments and technologies are constantly emerging, which will further expand sequencing applications. In parallel, single cell sequencing technologies are rapidly becoming a popular platform.
Автор: Wei Wu; Hani Choudhry Название: Next Generation Sequencing in Cancer Research ISBN: 1489988084 ISBN-13(EAN): 9781489988089 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume provides an interdisciplinary perspective of applying Next Generation Sequencing (NGS) technology to cancer research. It aims to systematically introduce the concept of NGS, a variety of NGS platforms and their practical implications in cancer biology.This unique and comprehensive text will integrate the unprecedented NGS technology into various cancer research projects as opposed to most books which offer a detailed description of the technology. This volume will present true experimental results with concrete data processing pipelines, discuss the bottleneck of each platform for real project in cancer research. In additional, single cancer cell sequencing as the proof of concept will be introduced in this book, along with cutting-edge information provided will help the intended audience to develop a comprehensive understanding of the NGS technology and practical whole genome sequencing data analysis and rapidly translate into their own research, specifically in the field of cancer biology.
Название: Deep sequencing data analysis ISBN: 1627035133 ISBN-13(EAN): 9781627035132 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details key data analysis procedures for deep sequencing data interpretation. It includes lists of necessary materials and reagents; step-by-step, readily reproducible protocols, and key tips on troubleshooting and avoiding known pitfalls.
Автор: Serghei Mangul; Harry Taegyun Yang; Eleazar Eskin; Название: Hidden Treasures in Contemporary RNA Sequencing ISBN: 3030139727 ISBN-13(EAN): 9783030139728 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Поставка под заказ.
Описание:
Advances in RNA-sequencing (RNA-seq) technologies have provided an unprecedented opportunity to explore the gene expression landscape across individuals, tissues, and environments by efficiently profiling the RNA sequences present in the samples. When a reference genome sequence or a transcriptome of the sample is available, mapping-based RNA-seq analysis protocols align the RNA-seq reads to the reference sequences, identify novel transcripts, and quantify the abundance of expressed transcripts.
The reads that fail to map to the human reference, known as unmapped reads, are a large and often overlooked output of standard RNA-seq analyses. Even in carefully executed experiments, the unmapped reads can comprise a considerable fraction of the complete set of reads produced, and can arise due to technical sequencing produced by low-quality and error-prone copies of the nascent RNA sequence being sampled. Reads can also remain unmapped due to unknown transcripts, recombined B and T cell receptor sequences, A-to-G mismatches from A-to-I RNA editing, trans-splicing, gene fusion, circular RNAs, and the presence of non-host RNA sequences (e.g. bacterial, fungal, and viral organisms). Unmapped reads represent a rich resource for the study of B and T cell receptor repertoires and the human microbiome system—without incurring the expense of additional targeted sequencing.
This book introduces and describes the Read Origin Protocol (ROP), a tool that identifies the origin of both mapped and unmapped reads. The protocol first identifies human reads using a standard high-throughput algorithm to map them onto a reference genome and transcriptome. After alignment, reads are grouped into genomic (e.g. CDS, UTRs, introns) and repetitive (e.g. SINEs, LINEs, LTRs) categories. The rest of the ROP protocol characterizes the remaining unmapped reads, which failed to map to the human reference sequences.
Описание: This book reviews the potential of next-generation sequencing (NGS) in research on and management of colorectal cancer (CRC), a leading cause of death worldwide and one of the most biologically and clinically heterogeneous cancers.
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