Описание: This thorough book explores some of the most important methods and concepts affecting the quantitative analysis of the transport, targeting, and disposition of chemicals within cells, which in turn impact the macroscopic pharmacokinetics of chemical agents in the whole organism. The first half of the volume focuses on small organic molecules with drug-like characteristics, while the second half delves into the cellular pharmacokinetics of biologics and other macromolecules, including peptide therapeutics, cyclotides, antibodies, as well as nanoparticles, thus creating a comprehensive treatise that approaches cellular pharmacokinetics from the different perspectives of pharmaceutical scientists, chemical biologists, medicinal chemists, and protein engineers dealing with very different chemical agents spanning a wide range of sizes, physicochemical properties, and targeting mechanisms. Written for the Methods in Pharmacology and Toxicology series, chapters provide the kind of key detail and expert implementation advice that leads to excellent results in the lab. Synthetic biologists, biophysicists, and bioengineers are amongst the long list of scientists who could benefit from reading this book or from using it as a textbook. Authoritative and practical, Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery builds on a long history of drug development and the adding of quantitative methods at the cellular scale in order to inspire new approaches to drug development that are better able to take advantage of phenomena such as soluble-to-insoluble phase transitions or bispecific targeting, which could ultimately be exploited for the development of more effective drug delivery systems and therapeutic agents.
1. Measurement of Transcellular Transport Rates and Intracellular Drug Sequestration in the Presence of an Extracellular Concentration Gradient
Kyoung Ah Min and Gus R. Rosania
2. Kinetic Design for Establishing Long Term Stationary Cytosol Concentrations during Drug Transport across P-gp Expressing Confluent Cell Monolayers to Facilitate Measuring Cytosol Concentration, Fitting Drug Molar Partition Coefficients into the Cytosolic Monolayer of the Plasma Membrane and Kinetically Identifying Drug Uptake Transporters
Joe Bentz
3. In Vitro Methodologies to Assess Potential for Transporter-Mediated Drug-Drug Interactions
Jibin Li, Qing Wang, and Ismael J. Hidalgo
4. Determination of Fraction Unbound and Unbound Partition Coefficient to Estimate Intracellular Free Drug Concentration
Sangwoo Ryu, Keith Riccardi, Samantha Jordan, Nathaniel Johnson, and Li Di
5. Quantitative Analysis of Intracellular Drug Concentrations in Hepatocytes
Chitra Saran, James J. Beaudoin, Nathan D. Pfeifer, and Kim L.R. Brouwer
6. Quantification of Intracellular Drug Aggregates and Precipitates
Phillip Rzeczycki and Gus R. Rosania
7. Quantitative Phenotypic Analysis of Drug Sequestering Macrophage Subpopulations
Mikhail D. Murashov
8. Using an Integrated QSAR Model to Check Whether Small-Molecule Xenobiotics Will Accumulate in Biomembranes, with Particular Reference to Fluorescent Imaging Probes
Richard W. Horobin and Juan C. Stockert
9. Diversity-Oriented Fluorescence Library Approach (DOFLA) for Discovery of Cell-Permeable Probes for Applications in Live Cell Imaging
Dongdong Su and Young-Tae Chang
Part II: Macromolecules, Biologics, and Nanoparticles
10. Overcoming Cellular and Systemic Barriers to Design the Next Wave of Peptide Therapeutics
Jerome Hochman, Tomi Sawyer, and Ruchia Duggal
11. Intracellular Targeting of Cyclotides for Therapeutic Applications
Nicole Lawrence and David J. Craik
12. Cellular Trafficking of Monoclonal and Bispecific Antibodies
John J. Rhoden and Christopher M. Wiethoff
13. Quantitative Drug Target Imaging Using Paired-Agent Principles
Kenneth M. Tichauer, Negar Sadeghipour, Yu "Winston" Wang, Summer L. Gibbs, Jonathan T.C. Liu, and Kimberley S. Samkoe
14. Quantitative Determination of Intracellular Bond Cleavage
Joshua A. Walker, Michelle R. Sorkin, and Christopher A. Alabi
15. Development and Application of a Single Cell-Level PK-PD Model for ADCs
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Автор: Corrado L. Galli; Marina Marinovich; Alan M. Goldb Название: Modulation of Cellular Responses in Toxicity ISBN: 3642798748 ISBN-13(EAN): 9783642798740 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Study Institute on the Modulation of Cellular Response in Toxicity, held in Ponte di Legno, Italy , January 24 - February 3, 1994.
Автор: Cynthia Rider; Jane Ellen Simmons Название: Chemical Mixtures and Combined Chemical and Nonchemical Stressors ISBN: 3319562320 ISBN-13(EAN): 9783319562322 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures.
Автор: Andrew F. Olshan; Donald R. Mattison Название: Male-Mediated Developmental Toxicity ISBN: 0306448157 ISBN-13(EAN): 9780306448157 Издательство: Springer Рейтинг: Цена: 30039.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of an international conference held in Pittsburgh, Pennsylvania, September 16-19, 1992
Описание: These volumes are designed to be the most complete guide to pharmacokinetics (PK) and its role in drug development. Geared toward graduate level students and scientists in the areas of clinical pharmacology and PK, the volumes will fill a gap between the academic science and the practical application of that knowledge in drug development. Volume 1 discusses the role that PK plays in selected clinical study designs, including first-time-in-man, biopharmaceuticals, and special population studies. Volume 2 details the key regulatory and development paradigms in which PK supplements decision-making during drug development.
Автор: Benfenati Название: In Silico Methods for Predicting Drug Toxicity ISBN: 1071619624 ISBN-13(EAN): 9781071619629 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This fully updated book explores all-new and revised protocols involving the use of in silico models, particularly with regard to pharmaceuticals. Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and implementation advice necessary for successful results. Authoritative and comprehensive, In Silico Methods for Predicting Drug Toxicity, Second Edition aims to guide the reader through the correct procedures needed to harness in silico models, a field which now touches a wide variety of research specialties.
Описание: Updated and revised, this fourth edition of a bestseller provides current and comprehensive information on all aspects of drug design and discovery. The first part of the book covers general aspects, methods, and principles and the second section covers specific targets and diseases. Topics new to this edition include biostructure- and ligand-based drug design, natural products, imaging, neurotransmitter transporters, opioid and cannabinoid receptors, hypnotics, neglected diseases, and antibiotics. Each chapter includes references for further study. Most chapters also supply background and history needed to provide context, as well as conclusions that summarize the important points.
Описание: In this book, both basic and advanced concepts are discussed for considering mixtures from initial exposure characterization through evaluation of risk associated with combined exposures. This book will provide an introduction to key issues and multiple options for evaluating both the toxicity of mixtures as well as the risk associated with exposure to mixtures. Additionally, promising tools adapted from other disciplines will be discussed in the context of mixtures toxicology and risk assessment. Finally, the discussion will move beyond chemical mixtures to address incorporating non-chemical stressors into toxicity studies and cumulative risk assessments. Although exposure to multiple chemical and non-chemical stressors is the rule, not the exception, consideration of mixtures in toxicology and risk assessment continues to be a significant challenge. This book will be an essential resource for researchers and professionals in the fields of toxicology, epidemiology, exposure science, risk assessment, and statistics.
Автор: Andrew F. Olshan; Donald R. Mattison Название: Male-Mediated Developmental Toxicity ISBN: 1461357640 ISBN-13(EAN): 9781461357643 Издательство: Springer Рейтинг: Цена: 28734.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of an international conference held in Pittsburgh, Pennsylvania, September 16-19, 1992
Автор: Saleena Mathew; Maya Raman; Manjusha Kalarikkathar Название: Fish and Fishery Products Analysis ISBN: 9813295767 ISBN-13(EAN): 9789813295766 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: This novel and informative book discusses the various aspects of seafood quality. The book is divided into 7 broad sections, each tackling a different aspect. The first section covers the general aspects relevant to the nutritional quality of the fish and the various extraction protocols for macro-/ micro-nutrients. The second section provides insights into handling and the principles of thermal and non-thermal processing techniques for commercially important fishery products. The quality standards and safety concerns in the seafood industry and consumption are discussed in this section. The freshness indices of the processed products including biochemical, microbiological and toxicological characteristics are also included. The third section discusses the physico-chemical characteristics and quality parameters of potable water/ ice. The fourth section includes the quality assessment of various toxicants related to seafood products. The fifth section deals with the specific aspects such as principle, instrument and procedures of conventional and novel analytical instruments relevant to the seafood industry. The sixth section deals with the seafood waste management including solid and liquid seafood wastes. Presently, there is a great awareness regarding environmental sustainable processing/ preservation techniques. The final chapter discusses the bioactive compounds from under-utilized marine sources showing pharmaceutical/ nutraceutical applications.
1. Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology Uttam Garg and Yan Victoria Zhang
2. Quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Matthew H. Slawson and Kamisha L. Johnson-Davis 3. Quantitation of the Oral Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Warfarin in Plasma Using Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry (UPLC-MS/MS) Jaime H. Noguez and James C. Ritchie 4. Simultaneous Quantitation of Lamotrigine, Levetiracetam, 10-Hydroxycarbazepine, Topiramate, and Zonisamide in Serum Using HPLC-MS/MS Dean C. Carlow, Heng Shi, and Ryan C. Schofield 5. Quantification of the Triazole Antifungal Compounds Voriconazole and Posaconazole in Human Serum or Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Alejandro R. Molinelli and Charles H. Rose, IV 6. Quantitation of Haloperidol, Fluphenazine, Perphenazine, and Thiothixene in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Matthew H. Slawson and Kamisha L. Johnson-Davis 7. Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS Stephanie J. Marin and Gwendolyn A. McMillin 8. Quantitation of Buprenorphine, Norbuprenorphine, Buprenorphine Glucuronide, Norbuprenorphine Glucuronide, and Naloxone in Urine by LC-MS/MS Stephanie J. Marin and Gwendolyn A. McMillin 9. A Simple Liquid Chromatography Tandem Mass Spectrometry Method for Quantification of Plasma Busulfan Shuang Deng, Michael Kiscoan, Clint Frazee, Susan Abdel-Rahman, Jignesh Dalal, and Uttam Garg 10. High-Throughput Quantitation of Busulfan in Plasma Using Ultra-Fast Solid Phase Extraction Tandem Mass Spectrometry (SPE-MS/MS) Loralie J. Langman, Darlington Danso, Enger Robert, and Paul J. Jannetto 11. Quantification of 11-Carboxy-Delta-9-Tetrahydrocannbinol (THC-COOH) in Meconium Using Gas Chromatography Mass Spectrometry (GC/MS) Judy Peat, Brehon Davis, Clint Frazee, and Uttam Garg 12. Quantitation of Carisoprodol and Meprobamate in Urine and Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Matthew H. Slawson and Kamisha L. Johnson-Davis 13. Cetirizine Quantification by High Performance Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS) Ada Munar, Clint Frazee, Bridgette Jones, and Uttam Garg 14. Quantification of Docetaxel in Serum Using Turbulent Flow Liquid Chromatography Electrospray Tandem Mass Spectrometry (TFC-HPLC-ESI-MS/MS) Christopher A. Crutchfield, Mark A. Marzinke and William Clarke 15. Comprehensive Urine Drug Screen by Gas-Chromatography Mass Spectrometry (GC/MS) Bheemraj Ramoo, Melissa Funke, Clint Frazee, and Uttam Garg 16. Broad Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry Judy Stone 17. High Resolution Mass Spectrometry for Untargeted Drug Screening Alan H.B. Wu and Jennifer Colby 18. Quantitation of Ethyl Glucuronide and Ethyl Sulfate in Urine Using Liquid Chromatography-Tandem Mass Spectrometry(LC-MS/MS) Matthew H. Slawson and Kamisha L. Johnson-Davis 19. Quantification of Hydroxychloroquine in Blood Using Turbulent Flow Liquid Chromatography-Tandem mass Soectrometry (TFLC-MS/MS) Allison B. Chambliss, Anna K. Fьzйry, and William A. Clarke 20. Quantification of Iohexol in Serum by High Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Faye B. Vicente, Gina Vespa, Alan Miller, and Shannon Haymond 21. Quantitation of Teriflunomide in Human Serum/Plasma Across a 4
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