Vaccines for Invasive Fungal Infections: Methods and Protocols, Kalkum Markus, Semis Margarita
Автор: Markus Kalkum; Margarita Semis Название: Vaccines for Invasive Fungal Infections ISBN: 1493971034 ISBN-13(EAN): 9781493971039 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed volume focuses on the development of mycosis vaccines via the most common etiological agents of mycoses, such as Aspergillus and Candida species, followed by Cryptococcus, dimorphic fungi, and members of Mucoraceae family of fungi.
Автор: R. Pandey; S. H?glund; G. Prasad Название: Veterinary Vaccines ISBN: 1461392284 ISBN-13(EAN): 9781461392286 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Solid-phase synthesis of peptides is leading to an array of synthetic vaccines, an approach that is expected to attain its full potential once the sequences activating suppressor cells are discovered and the rules for presentation of antigens to T and B cells are better worked out.
Автор: Almeida de Sousa Название: DNA Vaccines: Methods and Protocols ISBN: 1071608711 ISBN-13(EAN): 9781071608715 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume details practical procedures on the latest DNA vaccine technology. Chapters guide readers through methods and protocols on DNA vaccine design, the adjuvant influence, production and purification methodologies, delivery systems, and approaches of the influence of DNA vaccines in the immunological response performance and in the cancer immunotherapy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, DNA Vaccines: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Автор: Kramps Thomas, Elbers Knut Название: RNA Vaccines: Methods and Protocols ISBN: 1493982141 ISBN-13(EAN): 9781493982141 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Introduction to RNA Vaccines
Thomas Kramps and Knut Elbers
Part I: Self-replicating RNA Vectors
2. Self-replicating RNA
Birke A. Tews and Gregor Meyers
3. Self-replicating RNA Vaccine Delivery to Dendritic Cells
Thomas Dйmoulins, Pavlos C. Englezou, Panagiota Milona, Nicolas Ruggli, Nicola Tirelli, Chantal Pichon, Cйdric Sapet, Thomas Ebensen, Carlos A. Guzmбn, and Kenneth C. McCullough
4. Plant Expression of Trans-encapsidated Viral Nanoparticle Vaccines with Animal RNA Replicons
Yiyang Zhou, Alison A. McCormick, and Christopher M. Kearney
Part II: Non-replicating mRNA Vectors
5. RNActive(R) Technology: Generation and Testing of Stable and Immunogenic mRNA Vaccines
Susanne Rauch, Johannes Lutz, Aleksandra Kowalczyk, Thomas Schlake, and Regina Heidenreich
6. Nucleoside Modified mRNA Vaccines for Infectious Diseases
Norbert Pardi and Drew Weissman
7. Generation and Evaluation of Prophylactic mRNA Vaccines against Allergy
Richard Weiss, Sandra Scheiblhofer, and Josef Thalhamer
Part III: Adjuvantation and Delivery
8. Measuring the Adjuvant Activity of RNA Vaccines
Norbert Pardi and Drew Weissman
9. Generation of Immunostimulating 130 nm Protamine-RNA Nanoparticles
Marina Tusup and Steve Pascolo
10. Electroporation of mRNA as Universal Technology Platform to Transfect a Variety of Primary Cells with Antigens and Functional Proteins
Kerstin F. Gerer, Stefanie Hoyer, Jan Dцrrie, and Niels Schaft
11. Adjuvant-Enhanced mRNA Vaccines
Lukasz Bialkowski, Kevin Van der Jeught, Dries Renmans, Alexia van Weijnen, Carlo Heirman, Marleen Keyaerts, Karine Breckpot, and Kris Thielemans
12. Enhanced Delivery of DNA or RNA Vaccines by Electroporation
Kate E. Broderick and Laurent M. Humeau
Part IV: Preclinical and Clinical Development
13. The European Regulatory Environment of RNA-Based Vaccines
Thomas Hinz, Kajo Kallen, Cedrik M. Britten, Bruno Flamion, Ulrich Granzer, Axel Hoos, Christoph Huber, Samir Khleif, Sebastian Kreiter, Hans-Georg Rammensee, Ugur Sahin, Harpreet Singh-Jasuja, Цzlem Tьreci, and Ulrich Kalinke
14. Discovery and Subtyping of Neo-Epitope Specific T-cell Responses for Cancer Immunotherapy: Addressing the Mutanome
Mustafa Diken, Mathias Vormehr, Christian Grunwitz, Sebastian Kreiter, Цzlem Tьreci, and Ugur Sahin
15. Considerations for Producing mRNA Vaccines for Clinical Trials
Andreas Schmid
16. Nonclinical Safety Testing of RNA Vaccines
Gundel Hager
17. Immunotherapy of Uveal Melanoma: Vaccination Against Cancer
Mirko Kummer and Beatrice Schuler-Thurner
Автор: Ferran Maureen C., Skuse Gary R. Название: Recombinant Virus Vaccines: Methods and Protocols ISBN: 1493983237 ISBN-13(EAN): 9781493983230 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Preface... Table of Contents... Contributing Authors...
Part I Double-Stranded DNA Viruses
1. Development of Novel Vaccines Against Infectious Diseases Based on Chimpanzee Adenoviral Vector Chao Zhang, Yudan Chi, and Dongming Zhou
2. Development of Recombinant Canarypox Viruses Expressing Immunogens Dйbora Garanzini, Marнa Paula Del Mйdico-Zajac, and Gabriela Calamante
3. Fowl Adenovirus-Based Vaccine Platform Juan C. Corredor, Yanlong Pei, and Йva Nagy
4. Development of Recombinant HSV-Based Vaccine Vectors Richard Voellmy and David Bloom
5. Generating Recombinant Pseudorabies Virus for Use as a Vaccine Platform Feifei Tan, Xiangdong Li, and Kegong Tian
6. Generation and Production of Modified Vaccinia Virus Ankara (MVA) as a Vaccine Vector Vincent Pavot, Sarah Sebastian, Alison V. Turner, Jake Matthews, and Sarah C. Gilbert
7. Poxvirus Safety Analysis in the Pregnant Mouse Model, Vaccinia and Raccoonpox Viruses Rachel L. Roper
Part II Negative Sense Single-Stranded RNA viruses
8. Development of Recombinant Arenavirus-Based Vaccines Luis Martнnez-Sobrido and Juan Carlos de la Torre
9. Development of Recombinant Measles Virus-Based Vaccines Michael D. Mьhlebach and Stefan Hutzler
10. Recombinant Tri-Segmented Pichinde Virus as a Novel Live Viral Vaccine Platform Rekha Dhanwani, Hinh Ly, and Yuying Liang
11. Human Rhinovirus-A1 as an Expression Vector Khamis Tomusange, Danushka Wijesundara, Eric James Gowans, and Branka Grubor-Bauk
12. Generating Recombinant Vesicular Stomatitis Viruses for Use as Vaccine Platforms John B. Ruedas and John H. Connor
Part III Positive Sense Single-Stranded RNA viruses
13. Alphavirus-Based Vaccines Kenneth Lundstrom
Part IV Bacteriophage
14. Display of HIV-1 Envelope Protein on Lambda Phage Scaffold as a Vaccine Platform Jonelle L. Mattiacio, Matt Brewer, and Stephen Dewhurst
15. Bacteriophage T4 as a Nanoparticle Platform to Display and Deliver Pathogen Antigens: Construction of an Effective Anthrax Vaccine Pan Tao, Qin Li, Sathish Shivachandra, and Venigalla B. Rao
Автор: Bagnoli Fabio, Rappuoli Rino Название: Advanced Vaccine Research: Methods for the Decade of Vaccines ISBN: 1910190039 ISBN-13(EAN): 9781910190036 Издательство: Неизвестно Рейтинг: Цена: 45980.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Hironori Nakagami Название: Therapeutic Vaccines as Novel Immunotherapy ISBN: 9813296305 ISBN-13(EAN): 9789813296305 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Поставка под заказ.
Описание: This book offers an excellent introduction to the use of novel therapeutic vaccines for common diseases based on their ability to induce antibody production.
Автор: Dushyant Varshney; Manmohan Singh Название: Lyophilized Biologics and Vaccines ISBN: 1493955683 ISBN-13(EAN): 9781493955688 Издательство: Springer Рейтинг: Цена: 16070.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides a detailed account of the most recent developments, challenges and solutions to seamlessly advance and launch a lyophilized biologics or vaccine product, based on diverse modalities, ranging from antibodies (e.g., monoclonal, fused), complex biologics (e.g., antibody drug conjugate, PEGylated proteins), and vaccines (e.g., recombinant-protein based). The authors adeptly guide the reader through all crucial aspects, from biophysical and chemical stability considerations of proteins, analytical methods, advances in controlled ice nucleation and quality-by-design approaches, alternate drying technology, to latest regulatory, packaging and technology transfer considerations to develop a stable, safe and effective therapeutic protein, vaccine and biotechnology products. Lyophilized Biologics and Vaccines: Modality-Based Approaches is composed of four sections with a total of 17 chapters. It serves as a reference to all critical assessments and steps from early pre-formulation stages to product launch: * Provides recent understanding of heterogeneity of protein environment and selection of appropriate buffer for stabilization of lyophilized formulations * Details the latest developments in instrumental analysis and controlled ice nucleation technology * Explains in-depth lyophilized (or dehydrated) formulation strategies considering diverse modalities of biologics and vaccines, including plasmid DNA and lipid-based therapeutics * Details an exhaustive update on quality-by-design and process analytical technology approaches, illustrated superbly by case studies and FDA perspective * Provides the latest detailed account of alternate drying technologies including spray drying, bulk freeze-drying and crystallization, supported exceptionally by case studies * Provides a step-by-step guide through critical considerations during process scale-up, technology transfer, packaging and drug delivery device selection, for a successful lyophilization process validation, regulatory submission and product launch Chapters are written by one or more world-renowned leading authorities from academia, industry or regulatory agencies, whose expertise cover lyophilization of the diverse modalities of biopharmaceuticals. Their contributions are based on the exhaustive review of literature coupled with excellent hands-on experiences in laboratory or GMP setup, making this an exceptional guide to all stages of lyophilized or dehydrated product development.
Автор: Josef Thalhamer; Richard Weiss; Sandra Scheiblhofe Название: Gene Vaccines ISBN: 3709119294 ISBN-13(EAN): 9783709119297 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The induction of antigen-specific immune responses after in vivo transfection with expression plasmids has triggered a revolution of vaccine research. After a first hype, evoked by the fascinating options of this method, clinical studies did not reach the ambitious aims and a phase of disillusion ensued. It became obvious that Gene vaccines displayed a weaker immunogenicity in humans than had been observed in the mouse models. Meanwhile these hurdles have been overcome and gene vaccines undergo a renaissance. The present book gives an update of the “world of naked gene vaccines”, namely DNA and RNA vaccines. Its content ranges from general mechanisms, inherent immunostimulatory properties and the vast potential to modulate immune responses, to recent successful clinical studies and approved veterinary gene vaccines. Beyond the state-of-the-art of genetic immunization, the reader will be stimulated with a chapter addressing “burning questions”.
Автор: Hironori Nakagami Название: Therapeutic Vaccines as Novel Immunotherapy ISBN: 9813296275 ISBN-13(EAN): 9789813296275 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Поставка под заказ.
Описание: This book offers an excellent introduction to the use of novel therapeutic vaccines for common diseases based on their ability to induce antibody production. While the role of vaccines in the treatment of infectious diseases and cancer is well known, vaccines have also recently been developed for a variety of other conditions, including Alzheimer’s disease, hypertension, diabetes, and spondyloarthritis. These therapeutic advances are fully and clearly documented by acknowledged experts in the field, who explain the relevant biology and highlight the challenges involved in deploying this treatment approach effectively and safely. In addition, recent progress in the construction and delivery of DNA vaccines is documented, and the process of developing new peptide vaccines is explored in depth. While the book will be particularly valuable for researchers and scholars interested in immunotherapy, it will also appeal to clinicians seeking effective new medicines to treat patients suffering from chronic diseases.
Автор: Darren R. Flower; Yvonne Perrie Название: Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines ISBN: 1489997954 ISBN-13(EAN): 9781489997951 Издательство: Springer Рейтинг: Цена: 22201.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book details the discovery of antigens and adjuvants within the context of reverse vaccinology. It explores ways to make vaccines more effective.
Автор: Andrew W. Artenstein Название: Vaccines: A Biography ISBN: 1489983627 ISBN-13(EAN): 9781489983626 Издательство: Springer Рейтинг: Цена: 23058.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Why another book about vaccines? There are already a few extremely well-written medical textbooks that provide comprehensive, state-of-the-art technical reviews regarding vaccine science. Additionally, in the past decade alone, a number of engrossing, provocative books have been published on various related issues ra- ing from vaccines against specific diseases to vaccine safety and policy. Yet there remains a significant gap in the literature – the history of vaccines. Vaccines: A Biography seeks to fill a void in the extant literature by focusing on the history of vaccines and in so doing, recounts the social, cultural, and scientific history of vaccines; it places them within their natural, historical context. The book traces the lineage – the “biography” – of individual vaccines, originating with deeply rooted medical problems and evolving to an eventual conclusion. Nonetheless, these are not “biographies” in the traditional sense; they do not trace an individual’s growth and development. Instead, they follow an idea as it is conceived and dev- oped, through the contributions of many. These are epic stories of discovery, of risk-takers, of individuals advancing medical science, in the words of the famous physical scientist Isaac Newton, “by standing on the shoulders of giants. ” One grant reviewer described the book’s concept as “triumphalist”; although meant as an indictment, this is only partially inaccurate.
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