This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Giacca Mauro Название: Gene Therapy ISBN: 8847016428 ISBN-13(EAN): 9788847016422 Издательство: Springer Рейтинг: Цена: 11738.00 р. 16769.00-30% Наличие на складе: Есть (1 шт.) Описание: Gene Therapy presents a comprehensive overview of the field, ranging from vector development and therapeutic gene selection to the results of the most recent clinical trials. Written in a clear, didactic style, the volume makes gene therapy methods easily accessible to readers.
Автор: Turksen Название: Genome Editing ISBN: 3319341464 ISBN-13(EAN): 9783319341460 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
This timely volume explores the use of CRISPR-Cas9 for genome editing, presenting cutting-edge techniques and their applications in treatment of disease. The chapters describe latest methods such as use of targetable nucleases, investigation of the non-coding genome, mouse genome editing, increasing of knock-in efficiency in mouse zygotes, and generation of reporter stem cells; the text contextualizes these methods in treatment of cardiovascular disease, diabetes mellitus, retinitis pigmentosa, and others. The final chapters round out the book with a discussion of controversies and future directions.
Genome Editing is an essential, of-the-moment contribution to this rapidly growing field. Drawing from a wealth of international perspectives, it presents novel techniques and applications for the engineering of the human genome. This book is essential reading for all clinicians and researchers in stem cells, regenerative medicine, genomics, biochemical and biomedical engineering- especially those interested in learning more about genome editing and applying it in a targeted, specific way.
Автор: Toni Cathomen; Matthew Hirsch; Matthew Porteus Название: Genome Editing ISBN: 1493935070 ISBN-13(EAN): 9781493935079 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "American Society of Gene & Cell Therapy"--Cover.
Автор: Izuho Hatada Название: Genome Editing in Animals ISBN: 1493971271 ISBN-13(EAN): 9781493971275 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Construction and Evaluation of Zinc Finger Nucleases
Hiroshi Ochiai and Takashi Yamamoto
2. Current Overview of TALEN Construction Systems
Tetsushi Sakuma and Takashi Yamamoto
3. CRISPR/Cas9
Izuho Hatada and Takuro Horii
4. Computational Prediction of CRISPR/Cas9 Target Sites Reveals Potential Off-Target Risks in Human and Mouse
Qingbo Wang and Kumiko Ui-Tei
5. Genome Editing of Mouse by Cytoplasmic Injection
Takuro Horii and Izuho Hatada
6. Genome Editing in Mouse Zygotes and Embryonic Stem Cells by Introducing sgRNA/Cas9 Expressing Plasmids
Taichi Noda, Asami Oji, and Masahito Ikawa
7. Genome Editing in Mouse and Rat by Electroporation
Takehito Kaneko
8. Generation of Knock-in Mouse by Genome Editing
Wataru Fujii
9. Genome Editing of Rat
Takehito Kaneko
10. Gene Targeting in Rabbits: Single-step Generation of Knockout Rabbits by Microinjection of CRISPR/Cas9 Plasmids
Yoshihiro Kawano and Arata Honda
11. Genome Editing of Pig
Masahito Watanabe and Hiroshi Nagashima
12. Genome Editing of Monkey
Zhen Liu, Yijun Cai, and Qiang Sun
13. Genome Editing Mediated by Primordial Germ Cell in Chicken
Jae Yong Han and Hong Jo Lee
14. CRISPR/Cas9-mediated Targeted Knock-in of Exogenous Reporter Genes in Zebrafish
Atsuo Kawahara
15. Genome Editing of Medaka
Satoshi Ansai and Masato Kinoshita
16. A Simple Protocol for Loss-of-Function Analysis in Xenopus tropicalis Founders using the CRISPR-Cas System
Yuto Sakane, Ken-ich T Suzuki, and Takashi Yamamoto
17. Genome Editing of Silkworms
Takuya Tsubota and Hideki Sezutsu
18. Genome Editing in the Cricket, Gryllus bimaculatus
Takahito Watanabe, Sumihare Noji, and Taro Mito
19. Genome Editing of the Ascidian Ciona intestinalis with TALE Nuclease
Yasunori Sasakura, Keita Yoshida, and Nicholas Treen
20. &
Автор: Rudolf Jaenisch; Feng Zhang; Fred Gage Название: Genome Editing in Neurosciences ISBN: 3319601911 ISBN-13(EAN): 9783319601915 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book is open access under a CC BY 4.0 license.
CRISPR-Cas9 is a rapid, efficient, versatile and relatively cheap method for dissecting the molecular pathways that are the basis of life, as well as for investigating and potentially rectifying faults in these pathways that result in disease.
This book reviews how CRISPR-Cas9 and other genome editing techniques are advancing our understanding of development and function in the nervous system, uncovering the molecular causes of neurological disorders and providing tools for gene therapy.
Автор: Hatada Izuho Название: Genome Editing in Animals: Methods and Protocols ISBN: 1493983938 ISBN-13(EAN): 9781493983933 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Construction and Evaluation of Zinc Finger Nucleases
Hiroshi Ochiai and Takashi Yamamoto
2. Current Overview of TALEN Construction Systems
Tetsushi Sakuma and Takashi Yamamoto
3. CRISPR/Cas9
Izuho Hatada and Takuro Horii
4. Computational Prediction of CRISPR/Cas9 Target Sites Reveals Potential Off-Target Risks in Human and Mouse
Qingbo Wang and Kumiko Ui-Tei
5. Genome Editing of Mouse by Cytoplasmic Injection
Takuro Horii and Izuho Hatada
6. Genome Editing in Mouse Zygotes and Embryonic Stem Cells by Introducing sgRNA/Cas9 Expressing Plasmids
Taichi Noda, Asami Oji, and Masahito Ikawa
7. Genome Editing in Mouse and Rat by Electroporation
Takehito Kaneko
8. Generation of Knock-in Mouse by Genome Editing
Wataru Fujii
9. Genome Editing of Rat
Takehito Kaneko
10. Gene Targeting in Rabbits: Single-step Generation of Knockout Rabbits by Microinjection of CRISPR/Cas9 Plasmids
Yoshihiro Kawano and Arata Honda
11. Genome Editing of Pig
Masahito Watanabe and Hiroshi Nagashima
12. Genome Editing of Monkey
Zhen Liu, Yijun Cai, and Qiang Sun
13. Genome Editing Mediated by Primordial Germ Cell in Chicken
Jae Yong Han and Hong Jo Lee
14. CRISPR/Cas9-mediated Targeted Knock-in of Exogenous Reporter Genes in Zebrafish
Atsuo Kawahara
15. Genome Editing of Medaka
Satoshi Ansai and Masato Kinoshita
16. A Simple Protocol for Loss-of-Function Analysis in Xenopus tropicalis Founders using the CRISPR-Cas System
Yuto Sakane, Ken-ich T Suzuki, and Takashi Yamamoto
17. Genome Editing of Silkworms
Takuya Tsubota and Hideki Sezutsu
18. Genome Editing in the Cricket, Gryllus bimaculatus
Takahito Watanabe, Sumihare Noji, and Taro Mito
19. Genome Editing of the Ascidian Ciona intestinalis with TALE Nuclease
Yasunori Sasakura, Keita Yoshida, and Nicholas Treen
20. &
Автор: Summers Harvey Название: Gene Therapy: Biological Aspects and Applications ISBN: 1632421968 ISBN-13(EAN): 9781632421968 Издательство: Неизвестно Цена: 22806.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Nagy Habib Название: Cancer Gene Therapy ISBN: 1475773706 ISBN-13(EAN): 9781475773705 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes.
Автор: Yu-Chen Hu Название: Gene Therapy for Cartilage and Bone Tissue Engineering ISBN: 364253922X ISBN-13(EAN): 9783642539220 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: "Gene Therapy for Cartilage and Bone Tissue Engineering" outlines the tissue engineering and possible applications of gene therapy in the field of biomedical engineering as well as basic principles of gene therapy, vectors and gene delivery, specifically for cartilage and bone engineering.
Автор: Christopher H. Evans; Paul D. Robbins Название: Gene Therapy in Inflammatory Diseases ISBN: 3034895844 ISBN-13(EAN): 9783034895842 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gene therapy for inflammatory diseases is a new, burgeoning field of medicine. Edited by the undisputed pioneers of this area of research, this volume is the first devoted to its topic. It contains thirteen chapters, each written by leaders in their respective fields, that summarize the state of the art in developing novel, gene based treatments for inflammatory diseases. As well as providing an introduction to the basic concepts of gene therapy and the use of naked DNA approaches, the book describes the advances that have been made in applying them to arthritis, lupus, multiple sclerosis, diabetes, Sjogren s syndrome and transplantation.One chapter is devoted to discussing the first human clinical trials that apply gene therapy to the treatment of an inflammatory disease. As well as providing novel therapeutic approaches, gene therapy facilitates the development of new and improved animal models of disease; a chapter describing these advances is also included. As an up-to-date, timely book written by th
Автор: J. Vos Название: Viruses in Human Gene Therapy ISBN: 9401042462 ISBN-13(EAN): 9789401042468 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: It is now time to move away from the period of questioning whether gene therapy will be a useful part of the physician armamentarium to begin to actively teach the concepts and practices that make gene therapy a reality.
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