Автор: Michael Andreeff Название: Targeted Therapy of Acute Myeloid Leukemia ISBN: 1493913921 ISBN-13(EAN): 9781493913923 Издательство: Springer Рейтинг: Цена: 25155.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides an unprecedented overview of "Targeted Therapies" for acute myeloid leukemias. It aims at an almost comprehensive coverage of the diverse therapeutic strategies that have been developed during the last decade and are now being evaluated in early clinical trials. Paired and authoritative chapters by leading research scientists and clinicians explain basic concepts and clinical translation of topics that include the underlying genetic and proteomic abnormalities of AML, the development of novel nucleoside analogues, the roles of microRNAs, apoptosis regulators Bcl-2 and p53 and of critical cell signaling proteins such as PIM, FLT3, Raf/MEK, PI3K/AKT/mTOR and aurora kinases. Chapters on epigenetic mechanisms, nuclear receptors, cell surface antigens, the hypoxic leukemia microenvironment, stem cells and leukemia metabolism provide insights into leukemia cell vulnerabilities. Cell therapies utilizing T-, NK- and mesenchymal stem cells and progress in hematopoietic transplantation strategies round up this overview of the multi-dimensional therapeutic landscape in which leukemia specialists develop treatment strategies that are expected to make "leukemia history" in the near future.
Автор: Paolo Fortina; Eric Londin; Jason Y. Park; Larry J Название: Acute Myeloid Leukemia ISBN: 1493971409 ISBN-13(EAN): 9781493971404 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume describes up-to-date techniques used in understanding the molecular biology of acute myeloid leukemia (AML) and addressing advances in diagnosis, classification, prognostication, and therapeutic strategies to potentially impact overall patient survival.
Автор: Hehlmann Rьdiger Название: Chronic Myeloid Leukemia ISBN: 303071912X ISBN-13(EAN): 9783030719128 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Поставка под заказ.
Описание: This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health.
Автор: Chung-Che (Jeff) Chang; Robert S. Ohgami Название: Precision Molecular Pathology of Myeloid Neoplasms ISBN: 3319621440 ISBN-13(EAN): 9783319621449 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Written by experts in the field, Precision Molecular Pathology of Myeloid Neoplasms serves as a valuable resource for pathologists, hematologists/oncologists, fellows, and researchers in understanding the molecular pathology of myeloid neoplasms.
Автор: Judith E. Karp Название: Acute Myelogenous Leukemia ISBN: 1617376752 ISBN-13(EAN): 9781617376757 Издательство: Springer Рейтинг: Цена: 34799.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities.
Автор: A. Hagenbeek; B. L?wenberg Название: Minimal Residual Disease in Acute Leukemia 1986 ISBN: 9401083983 ISBN-13(EAN): 9789401083980 Издательство: Springer Рейтинг: Цена: 38433.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Relapse of leukemia following successful remission-induction therapy remains a major obstacle in the treatment of patients with acute leukemia.
Описание: Provides information about the current status of aclacinomycin A for the treatment of haematologic malignancies. The text includes accounts of the action of aclacinomycin A in myelodysplastic syndromes and of its efficacy in acute myeloid leukemias.
Автор: Rцllig Christoph, Ossenkoppele Gert J. Название: Acute Myeloid Leukemia ISBN: 3030726754 ISBN-13(EAN): 9783030726751 Издательство: Springer Цена: 16769.00 р. Наличие на складе: Поставка под заказ.
Описание: This book, written by a team of leading experts, provides a comprehensive overview of acute myeloid leukemia (AML), the most frequent acute leukemia in adults.
Автор: Iland Harry, Hertzberg Mark, Marlton Paula Название: Myeloid Leukemia: Methods and Protocols ISBN: 1607614561 ISBN-13(EAN): 9781607614562 Издательство: Springer Рейтинг: Цена: 20257.00 р. Наличие на складе: Поставка под заказ.
Описание: A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.
Автор: Hehlmann Название: Chronic Myeloid Leukemia ISBN: 3030719154 ISBN-13(EAN): 9783030719159 Издательство: Springer Рейтинг: Цена: 11179.00 р. Наличие на складе: Поставка под заказ.
Описание: This book provides state-of-the-art reviews of key issues and recent developments relating to chronic myeloid leukemia (CML), acquainting the reader with advances in research, treatment, and promotion of public health.
Автор: Carella Название: Chronic Myeloid Leukaemia ISBN: 185317890X ISBN-13(EAN): 9781853178900 Издательство: Informa Рейтинг: Цена: 15886.00 р. Наличие на складе: Нет в наличии.
Описание: Drawing on the expertise of an international team of experts in chronic myeloid leukemia, this book provides insight into the latest advances and the implications those developments have for management of the disease. The editors and their panel of contributors explore many topics, including a review of molecular and cellular biology, a discussion of conventional chemotherapy and interferon therapy, and recent developments in allografting and autografting. The reader gains not only an incisive view of the biological structure of the disease, but applications of that biology to treatment modalities. The book emphasizes treatment strategies and is a guide to complex treatment options.
Автор: Richard Greil; Lisa Pleyer; Daniel Neureiter; Vikt Название: Chronic Myeloid Neoplasias and Clonal Overlap Syndromes ISBN: 3709120039 ISBN-13(EAN): 9783709120033 Издательство: Springer Рейтинг: Цена: 30745.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Introduction The understanding of the genetic, epigenetic, immuno- well as for practicing hematologists or oncologists. logical and biological causes of myeloproliferative dis- Each chapter follows a similar architecture and leads orders has substantially improved in the last few years. through epidemiology, genetic and molecular causes, Together with refined tools in pathology, the successful hematological and clinical findings, prognostic factors establishment of mouse models mimicking at least some and current treatment approaches of the diseases. of the myeloproliferative disorders, and murine models Effort has been made to point out the evolving field of novel drugs in this arena but simultaneously diff- allowing to carefully dissect the role of mutations and gene dosage effects of, for example JAK2, this has led to entiate between standard and experimental treatment ever increasing numbers of modified classification approaches. schemes. It is therefore important for the heamtologist Together with the co-editors and all the authors of or oncologist to keep up with this rapid change in classi- the various chapters I hope that the readers of the book fication language, the upcoming of new entities or differ- will enjoy reading and benefit from the information entiation between, or subclassification of, rare diseases provided.
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