Proteins and Non-protein Nitrogen in Human Milk, Atkinson, Stephanie
Автор: Hieronim Jakubowski Название: Homocysteine in Protein Structure/Function and Human Disease ISBN: 3709117208 ISBN-13(EAN): 9783709117200 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
Автор: Caterina Barone; Marcella Barebera; Michele Barone Название: Chemical Evolution of Nitrogen-based Compounds in Mozzarella Cheeses ISBN: 3319657372 ISBN-13(EAN): 9783319657370 Издательство: Springer Рейтинг: Цена: 7685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This Brief evaluates the consequences of protein modifications in cheeses, with special emphasis on mozzarella cheeses. As certain biogenic amines display a toxic potential to humans, considerable research has been undertaken in recent years to evaluate their presence in fermented foods, such as cheeses.
Автор: Markus W. Ribbe Название: Nitrogen Fixation ISBN: 1493958410 ISBN-13(EAN): 9781493958412 Издательство: Springer Рейтинг: Цена: 20263.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book offers an in-depth overview of the methods that have been applied to studying the nitrogenase at a molecular level, ranging from genetic, biochemical, spectroscopic and chemical methods to theoretical calculations.
Название: Protein Crystallography ISBN: 1782627286 ISBN-13(EAN): 9781782627289 Издательство: Royal Society of Chemistry Рейтинг: Цена: 33581.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With contributions from world leading researchers whose software are used worldwide, this book provides a coherent approach on how to handle difficult crystallographic data and how to assess its quality. The chapters will cover all key aspects of protein crystallography, from instrumentation and data processing through to model building. This book also addresses challenges that protein crystallographers will face such as dealing with data from microcrystals and multi protein complexes. This book is ideal for both academics and researchers in industry looking for a comprehensive guide to protein crystallography.
Описание: Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis.
Описание: This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by the body's own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases. PrPC is predominant in ?-helices but PrPSc are rich in ?-sheets in the form as amyloid fibrils; so very amenable to be studied by MD techniques. Through MD, studies on the protein structures and the structural conversion are very important for revealing secrets of prion diseases and for structure-based drug design or discovery. Rabbits, dogs, horses and buffaloes are reported to be the few low susceptibility species to prion diseases; this book's MD studies on these species are clearly helpful to understand the mechanism underlying the resistance to prion diseases. PrP(1-120) usually has no clear molecular structures; this book also studies this unstructured region through MD and especially MM techniques from the global optimization point of view. This book is ideal for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics, cheminformatics, materials science and engineering, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.
Автор: Alexzander A.A. Asea; Naif N. Almasoud; Sunil Kris Название: Heat Shock Protein-Based Therapies ISBN: 3319172107 ISBN-13(EAN): 9783319172101 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Contents
Contributors Preface SECTION I: HEAT SHOCK PROTEIN HSP27-BASED THERAPIES 1 HSP27 as a Therapeutic Target of Novel Inhibitors and Dietary Phytochemicals in Cancer Elena Arechaga-Ocampo and Cйsar Lуpez-Camarillo 2 Heat Shock Protein 27 (HSP27, HSPB1) is Up-Regulated by Targeted Agents and Confers Resistance to Both Targeted Drugs and Chemotherapeutics Daniele Musiani, John D. Konda, Simona Pavan, Erica Torchiaro, Jessica Erriquez, Martina Olivero and Maria F. Di Renzo 3 Heat Shock Proteins and Cancer: Plant Based Therapy Evren Цnay-Ucar SECTION II: HEAT SHOCK PROTEIN HSP60-BASED THERAPIES 4 Chaperonotherapy for Alzheimer's Disease: Focusing on HSP60 Francesco Cappello, Antonella M. Gammazza, Silvia Vilasi, Maria G. Ortore, Pier L. San-Biagio, Claudia Campanella, Andrea Pace, Antonio P. Piccionello, Giulio Taglialatela, Everly C. De Macario and Alberto J. l. Macario 5 Secreted and Circulating Cell Stress Proteins in the Periodontal Diseases Brian Henderson, Nikos Donos, Luigi Nibali and Frank Kaiser SECTION III: HEAT SHOCK PROTEIN HSP70-BASED THERAPIES 6 The Role of Heat Shock Protein 70 in Infection and Immunity Jose Rey-Ladino, Abiola Senok, Abdullah Sarkar and Ahlam Al Shedoukhy 7 Potential Cytoprotective Effects of Heat Shock Proteins to Skeletal Muscle John P. Vardiman, Philip M. Gallagher and Jacob A. Siedlik 8 Heat Shock Proteins in Triple-Negative Breast Cancer (TNBC) TreatmentPunit Kaurunit Kaur, Tarundeep arundeep Singh, Moses Galukandealukande, Sunil Krishnanrishnan and Alexzander A. A. Asealexzander Asea 9 Heat Shock Proteins in Multiple Sclerosis Pathogenesis: Friend or Foe? Rosaria Tinnirello, Giuseppina Turturici, Gabriella Sconzo, Walter Spinello, Alexzander A. A. Asea and Fabiana Geraci
10 New Indications for HSP90 and HSP70 Inhibitors as Antiviral Drugs Matthew K. Howe and Timothy A. J. Haystead 11 Potential Applications of Nanoparticles for Hyperthermia Caio C. Quini and Sunil Krishnan SECTION IV: HEAT SHOCK PROTEIN HSP90-BASED THERAPIES 12 Gene Therapy Against HSP90: Glucocorticoid Receptor-Assisted Cancer Treatment Susanta S. Adhikari, Sujan K. Mondal and Rajkumar Banerjee 13 Potential of HSP90 Inhibitors to Treat Neurofibromatosis-Related Tumors Jeremie Vitte and Marco Giovannini 14 Role of Heat Shock Protein 90 in the Cause of Various Diseases: A Potential Therapeutic Target Subhankar Paul 15 HSP90 Inhibitor-Based Strategies for Cancer Therapy: Advancing Toward Clinical Impact David A. Proia and Richard C. Bates 16 Molecular Survival Strategies of Organisms: HSP and Small Molecules for Diagnostics and Drug Development Andreas Kirschning, Johanna-Gabriela Walter, Frank Stahl, Emilia Schax, Thomas Scheper, Pooyan Aliuos and Carsten Zeilinger 17 Targeting Heat Shock Proteins in Colorectal Cancer Sheah L. Lee, Nina C. Dempsey-Hibbert, Dale Vimalachandran, Terence D. Wardle, Paul Sutton and John H. H. Williams Index
Автор: Dr. Mahboob Ul Hussain Название: Connexins: The Gap Junction Proteins ISBN: 813221918X ISBN-13(EAN): 9788132219187 Издательство: Springer Рейтинг: Цена: 7685.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gap-junction proteins, connexins are important cellular entities that regulate various facets of cellular physiology. The connexins constitute large family of proteins. The present book provides basic overview about various aspects of connexin proteins. The book has tried to touch the fundamental aspects of connexin family. This book will be useful to broad audience that includes under-and post-graduate students, research scholars, clinicians, etc. The reference section at the end of the book will be helpful for those who seek to know deeper details about this family of proteins.
Автор: Vladimir N. Uversky Название: Intrinsically Disordered Proteins ISBN: 331908920X ISBN-13(EAN): 9783319089201 Издательство: Springer Рейтинг: Цена: 9141.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs).
Автор: Ben-Naim Arieh Название: Protein Folding Problem And Its Solutions, The ISBN: 9814436356 ISBN-13(EAN): 9789814436359 Издательство: World Scientific Publishing Рейтинг: Цена: 15840.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents a new approach to the Protein Folding Problem. It starts with a clear description of what the protein folding problem involves. Then, it suggests non-conventional answers to some of the questions posed. In particular, it emphasizes the importance of hydrophilic interactions and hydrophilic forces, rather than the hydrophobic effects, for the stability of the native structure of proteins, as well for the speed of the folding process.
Автор: Permyakov Название: Calcium Binding Proteins ISBN: 0470525843 ISBN-13(EAN): 9780470525845 Издательство: Wiley Рейтинг: Цена: 25019.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution.
Автор: Arieh Ben-Naim Название: The Protein Folding Problem and Its Solutions ISBN: 9814436364 ISBN-13(EAN): 9789814436366 Издательство: World Scientific Publishing Рейтинг: Цена: 4277.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book presents a new approach to the Protein Folding Problem. It starts with a clear description of what the protein folding problem involves. Then, it suggests non-conventional answers to some of the questions posed. In particular, it emphasizes the importance of hydrophilic interactions and hydrophilic forces, rather than the hydrophobic effects, for the stability of the native structure of proteins, as well for the speed of the folding process.
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