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Proteins and Non-protein Nitrogen in Human Milk, Atkinson, Stephanie


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Автор: Atkinson, Stephanie
Название:  Proteins and Non-protein Nitrogen in Human Milk
ISBN: 9780849367953
Издательство: Taylor&Francis
Классификация:
ISBN-10: 0849367956
Обложка/Формат: Hardcover
Вес: 0.68 кг.
Язык: English
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Поставляется из: Европейский союз


Homocysteine in Protein Structure/Function and Human Disease

Автор: Hieronim Jakubowski
Название: Homocysteine in Protein Structure/Function and Human Disease
ISBN: 3709117208 ISBN-13(EAN): 9783709117200
Издательство: Springer
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Цена: 18167.00 р.
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Описание: Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.

Chemical Evolution of Nitrogen-based Compounds in Mozzarella Cheeses

Автор: Caterina Barone; Marcella Barebera; Michele Barone
Название: Chemical Evolution of Nitrogen-based Compounds in Mozzarella Cheeses
ISBN: 3319657372 ISBN-13(EAN): 9783319657370
Издательство: Springer
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Цена: 7685.00 р.
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Описание: This Brief evaluates the consequences of protein modifications in cheeses, with special emphasis on mozzarella cheeses. As certain biogenic amines display a toxic potential to humans, considerable research has been undertaken in recent years to evaluate their presence in fermented foods, such as cheeses.

Nitrogen Fixation

Автор: Markus W. Ribbe
Название: Nitrogen Fixation
ISBN: 1493958410 ISBN-13(EAN): 9781493958412
Издательство: Springer
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Цена: 20263.00 р.
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Описание: This book offers an in-depth overview of the methods that have been applied to studying the nitrogenase at a molecular level, ranging from genetic, biochemical, spectroscopic and chemical methods to theoretical calculations.

Protein Crystallography

Название: Protein Crystallography
ISBN: 1782627286 ISBN-13(EAN): 9781782627289
Издательство: Royal Society of Chemistry
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Цена: 33581.00 р.
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Описание: Protein crystallography has become vital to further understanding the structure and function of many complex biological systems. In recent years, structure determination has progressed tremendously however the quality of crystals and data sets can prevent the best results from being obtained. With contributions from world leading researchers whose software are used worldwide, this book provides a coherent approach on how to handle difficult crystallographic data and how to assess its quality. The chapters will cover all key aspects of protein crystallography, from instrumentation and data processing through to model building. This book also addresses challenges that protein crystallographers will face such as dealing with data from microcrystals and multi protein complexes. This book is ideal for both academics and researchers in industry looking for a comprehensive guide to protein crystallography.

Cholesterol Transporters of the START Domain Protein Family in Health and Disease

Автор: Barbara J. Clark; Douglas M. Stocco
Название: Cholesterol Transporters of the START Domain Protein Family in Health and Disease
ISBN: 1493954032 ISBN-13(EAN): 9781493954032
Издательство: Springer
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Цена: 16769.00 р.
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Описание: Non-vesicular intracellular cholesterol transport is an important mechanism for maintaining membrane cholesterol homeostasis. Recent reports of studies directed at soluble cholesterol transport proteins indicate that aberrant expression of the START proteins may contribute to disease states associated with disorders in cholesterol homeostasis.

Molecular Structures and Structural Dynamics of Prion Proteins and Prions

Автор: Jiapu Zhang
Название: Molecular Structures and Structural Dynamics of Prion Proteins and Prions
ISBN: 9401773173 ISBN-13(EAN): 9789401773171
Издательство: Springer
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Цена: 23757.00 р.
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Описание: This monograph is the first easy-to-read-and-understand book on prion proteins' molecular dynamics (MD) simulations and on prions' molecular modelling (MM) constructions. It enables researchers to see what is crucial to the conformational change from normal cellular prion protein (PrPC) to diseased infectious prions (PrPSc), using MD and MM techniques. As we all know, prion diseases, caused by the body's own proteins, are invariably fatal and highly infectious neurodegenerative diseases effecting humans and almost all animals for a major public health concern. Prion contains no nucleic acids and it is a misshapen or conformation-changed protein that acts like an infectious agent; thus prion diseases are called “protein structural conformational” diseases. PrPC is predominant in ?-helices but PrPSc are rich in ?-sheets in the form as amyloid fibrils; so very amenable to be studied by MD techniques. Through MD, studies on the protein structures and the structural conversion are very important for revealing secrets of prion diseases and for structure-based drug design or discovery. Rabbits, dogs, horses and buffaloes are reported to be the few low susceptibility species to prion diseases; this book's MD studies on these species are clearly helpful to understand the mechanism underlying the resistance to prion diseases. PrP(1-120) usually has no clear molecular structures; this book also studies this unstructured region through MD and especially MM techniques from the global optimization point of view. This book is ideal for practitioners in computing of biophysics, biochemistry, biomedicine, bioinformatics, cheminformatics, materials science and engineering, applied mathematics and theoretical physics, information technology, operations research, biostatistics, etc. As an accessible introduction to these fields, this book is also ideal as a teaching material for students.

Heat Shock Protein-Based Therapies

Автор: Alexzander A.A. Asea; Naif N. Almasoud; Sunil Kris
Название: Heat Shock Protein-Based Therapies
ISBN: 3319172107 ISBN-13(EAN): 9783319172101
Издательство: Springer
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Цена: 23508.00 р.
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Описание:

Contents

Contributors
Preface

SECTION I: HEAT SHOCK PROTEIN HSP27-BASED THERAPIES
1 HSP27 as a Therapeutic Target of Novel Inhibitors and Dietary Phytochemicals in Cancer
Elena Arechaga-Ocampo and Cйsar Lуpez-Camarillo
2 Heat Shock Protein 27 (HSP27, HSPB1) is Up-Regulated by Targeted Agents and Confers Resistance to Both Targeted Drugs and Chemotherapeutics
Daniele Musiani, John D. Konda, Simona Pavan, Erica Torchiaro, Jessica Erriquez, Martina Olivero and Maria F. Di Renzo

3 Heat Shock Proteins and Cancer: Plant Based Therapy
Evren Цnay-Ucar

SECTION II: HEAT SHOCK PROTEIN HSP60-BASED THERAPIES
4 Chaperonotherapy for Alzheimer's Disease: Focusing on HSP60
Francesco Cappello, Antonella M. Gammazza, Silvia Vilasi, Maria G. Ortore, Pier L. San-Biagio, Claudia Campanella, Andrea Pace, Antonio P. Piccionello, Giulio Taglialatela, Everly C. De Macario and Alberto J. l. Macario

5 Secreted and Circulating Cell Stress Proteins in the Periodontal Diseases
Brian Henderson, Nikos Donos, Luigi Nibali and Frank Kaiser

SECTION III: HEAT SHOCK PROTEIN HSP70-BASED THERAPIES

6 The Role of Heat Shock Protein 70 in Infection and Immunity
Jose Rey-Ladino, Abiola Senok, Abdullah Sarkar and Ahlam Al Shedoukhy

7 Potential Cytoprotective Effects of Heat Shock Proteins to Skeletal Muscle
John P. Vardiman, Philip M. Gallagher and Jacob A. Siedlik

8 Heat Shock Proteins in Triple-Negative Breast Cancer (TNBC) TreatmentPunit Kaurunit Kaur, Tarundeep arundeep Singh, Moses Galukandealukande, Sunil Krishnanrishnan and Alexzander A. A. Asealexzander Asea

9 Heat Shock Proteins in Multiple Sclerosis Pathogenesis: Friend or Foe?
Rosaria Tinnirello, Giuseppina Turturici, Gabriella Sconzo, Walter Spinello, Alexzander A. A. Asea and Fabiana Geraci

10 New Indications for HSP90 and HSP70 Inhibitors as Antiviral Drugs
Matthew K. Howe and Timothy A. J. Haystead

11 Potential Applications of Nanoparticles for Hyperthermia
Caio C. Quini and Sunil Krishnan

SECTION IV: HEAT SHOCK PROTEIN HSP90-BASED THERAPIES

12 Gene Therapy Against HSP90: Glucocorticoid Receptor-Assisted Cancer Treatment
Susanta S. Adhikari, Sujan K. Mondal and Rajkumar Banerjee

13 Potential of HSP90 Inhibitors to Treat Neurofibromatosis-Related Tumors
Jeremie Vitte and Marco Giovannini

14 Role of Heat Shock Protein 90 in the Cause of Various Diseases: A Potential Therapeutic Target
Subhankar Paul

15 HSP90 Inhibitor-Based Strategies for Cancer Therapy: Advancing Toward Clinical Impact
David A. Proia and Richard C. Bates

16 Molecular Survival Strategies of Organisms: HSP and Small Molecules for Diagnostics and Drug Development
Andreas Kirschning, Johanna-Gabriela Walter, Frank Stahl, Emilia Schax, Thomas Scheper, Pooyan Aliuos and Carsten Zeilinger
17 Targeting Heat Shock Proteins in Colorectal Cancer
Sheah L. Lee, Nina C. Dempsey-Hibbert, Dale Vimalachandran, Terence D. Wardle, Paul Sutton and John H. H. Williams

Index

Connexins: The Gap Junction Proteins

Автор: Dr. Mahboob Ul Hussain
Название: Connexins: The Gap Junction Proteins
ISBN: 813221918X ISBN-13(EAN): 9788132219187
Издательство: Springer
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Цена: 7685.00 р.
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Описание: Gap-junction proteins, connexins are important cellular entities that regulate various facets of cellular physiology. The connexins constitute large family of proteins. The present book provides basic overview about various aspects of connexin proteins. The book has tried to touch the fundamental aspects of connexin family. This book will be useful to broad audience that includes under-and post-graduate students, research scholars, clinicians, etc. The reference section at the end of the book will be helpful for those who seek to know deeper details about this family of proteins.

Intrinsically Disordered Proteins

Автор: Vladimir N. Uversky
Название: Intrinsically Disordered Proteins
ISBN: 331908920X ISBN-13(EAN): 9783319089201
Издательство: Springer
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Цена: 9141.00 р.
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Описание: In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs).

Protein Folding Problem And Its Solutions, The

Автор: Ben-Naim Arieh
Название: Protein Folding Problem And Its Solutions, The
ISBN: 9814436356 ISBN-13(EAN): 9789814436359
Издательство: World Scientific Publishing
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Цена: 15840.00 р.
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Описание: This book presents a new approach to the Protein Folding Problem. It starts with a clear description of what the protein folding problem involves. Then, it suggests non-conventional answers to some of the questions posed. In particular, it emphasizes the importance of hydrophilic interactions and hydrophilic forces, rather than the hydrophobic effects, for the stability of the native structure of proteins, as well for the speed of the folding process.

Calcium Binding Proteins

Автор: Permyakov
Название: Calcium Binding Proteins
ISBN: 0470525843 ISBN-13(EAN): 9780470525845
Издательство: Wiley
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Цена: 25019.00 р.
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Описание: Calcium Binding Proteins explains the unique and highly diverse functions of calcium in biology, which are realized by calcium binding proteins. The structures and physical characteristics of these calcium binding proteins are described, as well as their functions and general patterns of their evolution.

The Protein Folding Problem and Its Solutions

Автор: Arieh Ben-Naim
Название: The Protein Folding Problem and Its Solutions
ISBN: 9814436364 ISBN-13(EAN): 9789814436366
Издательство: World Scientific Publishing
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Цена: 4277.00 р.
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Описание: This book presents a new approach to the Protein Folding Problem. It starts with a clear description of what the protein folding problem involves. Then, it suggests non-conventional answers to some of the questions posed. In particular, it emphasizes the importance of hydrophilic interactions and hydrophilic forces, rather than the hydrophobic effects, for the stability of the native structure of proteins, as well for the speed of the folding process.


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