Quantitative Drug Design, Martin, Yvonne C.

Автор: Tozer
Название: Introduction to Pharmacokinetics and Pharmacodynamics: The Quantitative Basis of Drug Therapy
ISBN: 0781751497 ISBN-13(EAN): 9780781751490
Издательство: Lippincott Williams & Wilkins
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Цена: 7379.00 р.
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Описание: This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

Автор: R.B. Barlow
Название: Quantitative Aspects of Chemical Pharmacology
ISBN: 0709903006 ISBN-13(EAN): 9780709903000
Издательство: Springer
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Цена: 12157.00 р.
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Автор: Roy Kunal
Название: Quantitative Structure-Activity Relationships in Drug Design, Predictive Toxicology, and Risk Assessment
ISBN: 1466681365 ISBN-13(EAN): 9781466681361
Издательство: Mare Nostrum (Eurospan)
Цена: 46728.00 р.
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Описание: "This book discusses recent advancements in the field of QSARs with special reference to their application in drug development, predictive toxicology, and chemical risk analysis"--Provided by publisher.

Автор: Chuang-Stein Christy, Kirby Simon
Название: Quantitative Decisions in Drug Development
ISBN: 3319834347 ISBN-13(EAN): 9783319834344
Издательство: Springer
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Цена: 9083.00 р.
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Описание: Clinical Testing of a New Drug.- A Frequentist Decision-making Framework.- Characteristics of a Diagnostic Test.- The Parallel Between Clinical Trials and Diagnostic Tests.- Incorporating Information from Completed Trials in Future Trial Planning.- Choosing Metrics Appropriate for Different Stages of Drug Development.- Designing Proof-of-Concept Trials with Desired Characteristics.- Designing Dose-response Studies with Desired Characteristics.- Designing Confirmatory Trials with Desired Characteristics.- Designing Phase 4 Trials.- Other Metrics That Have Been Proposed to Optimize Drug Development Decisions.- Discounting Prior Results to Account for Selection Bias.- Index.- Appendix.

Автор: Chuang-stein, Christy Kirby, Simon
Название: Quantitative decisions in drug development
ISBN: 3030797309 ISBN-13(EAN): 9783030797300
Издательство: Springer
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Цена: 8384.00 р.
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Описание: This book focuses on important decision points and evidence needed for making decisions at these points during the development of a new drug.

Автор: Chuang-Stein
Название: Quantitative Decisions in Drug Development
ISBN: 3030797333 ISBN-13(EAN): 9783030797331
Издательство: Springer
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Цена: 8384.00 р.
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Описание: This book focuses on important decision points and evidence needed for making decisions at these points during the development of a new drug. It takes a holistic approach towards drug development by incorporating explicitly knowledge learned from the earlier part of the development and available historical information into decisions at later stages. In addition, the book shares lessons learned from several select examples published in the literature since the publication of the first edition. The second edition reiterates the need for making evidence-based Go/No Go decisions in drug development discussed in the first edition. It substantially expands several topics that have seen great advances since the publication of the first edition. The most noticeable additions include three adaptive trials conducted in recent years that offer excellent learning opportunities, the use of historical data in the design and analysis of clinical trials, and extending decision criteria to the cases when the primary endpoint is binary. The examples used to illustrate the additional materials all come from real trials with some post-trial reflections offered by the authors. The book begins with an overview of product development and regulatory approval pathways. It then discusses how to incorporate prior knowledge into study design and decision making at different stages of drug development. Prior knowledge includes information pertaining to historical controls. To assist decision making, the book discusses appropriate metrics and the formulation of go/no-go decisions for progressing a drug candidate to the next development stage. Using the concept of the positive predictive value in the field of diagnostics, the book leads readers to the assessment of the probability that an investigational product is effective given positive study outcomes. Lastly, the book points out common mistakes made by drug developers under the current drug-development paradigm. The book offers useful insights to statisticians, clinicians, regulatory affairs managers and decision-makers in the pharmaceutical industry who have a basic understanding of the drug-development process and the clinical trials conducted to support drug-marketing authorization. The authors provide software codes for select analytical approaches discussed in the book. The book includes enough technical details to allow statisticians to replicate the quantitative illustrations so that they can generate information to facilitate decision-making themselves.

Автор: Martin, Yvonne C.
Название: Quantitative Drug Design
ISBN: 0367384140 ISBN-13(EAN): 9780367384142
Издательство: Taylor&Francis
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Цена: 9798.00 р.
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Описание:

Since the publication of the first edition, the field has changed dramatically. Scientists can now explicitly consider 3D features in quantitative structure-activity relationship (QSAR) studies and often have the 3D structure of the macromolecular target to guide the 3D QSAR. Improvements in computer hardware and software have also made the methods more accessible to scientists. Taking these developments into account, Quantitative Drug Design: A Critical Introduction, Second Edition shows scientists how to apply QSAR techniques at a state-of-the-art level.

Автор: Rosania Gus R., Thurber Greg M.
Название: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery
ISBN: 1071612492 ISBN-13(EAN): 9781071612491
Издательство: Springer
Цена: 16769.00 р.
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Описание:

Part I: Small Molecules

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Автор: Rosania
Название: Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery
ISBN: 1071612522 ISBN-13(EAN): 9781071612521
Издательство: Springer
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Цена: 16769.00 р.
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Описание: This thorough book explores some of the most important methods and concepts affecting the quantitative analysis of the transport, targeting, and disposition of chemicals within cells, which in turn impact the macroscopic pharmacokinetics of chemical agents in the whole organism. The first half of the volume focuses on small organic molecules with drug-like characteristics, while the second half delves into the cellular pharmacokinetics of biologics and other macromolecules, including peptide therapeutics, cyclotides, antibodies, as well as nanoparticles, thus creating a comprehensive treatise that approaches cellular pharmacokinetics from the different perspectives of pharmaceutical scientists, chemical biologists, medicinal chemists, and protein engineers dealing with very different chemical agents spanning a wide range of sizes, physicochemical properties, and targeting mechanisms. Written for the Methods in Pharmacology and Toxicology series, chapters provide the kind of key detail and expert implementation advice that leads to excellent results in the lab. Synthetic biologists, biophysicists, and bioengineers are amongst the long list of scientists who could benefit from reading this book or from using it as a textbook. Authoritative and practical, Quantitative Analysis of Cellular Drug Transport, Disposition, and Delivery builds on a long history of drug development and the adding of quantitative methods at the cellular scale in order to inspire new approaches to drug development that are better able to take advantage of phenomena such as soluble-to-insoluble phase transitions or bispecific targeting, which could ultimately be exploited for the development of more effective drug delivery systems and therapeutic agents.

Автор: Liang-tseng Fan; Satish K. Singh
Название: Controlled Release
ISBN: 3642745091 ISBN-13(EAN): 9783642745096
Издательство: Springer
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Цена: 15672.00 р.
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Описание: The concept of controlled release has attracted increasing attention over the last two decades, with the applications of this technology proliferating in diverse fields in- cluding medicine, agriculture and biotechnology. The number and variety of controlled release systems, differing in their physical and chemical makeup, are increasing rapidly.

Автор: J. Clemmesen; A. Waring; D.M. Conning; D. Henschle
Название: Quantitative Aspects of Risk Assessment in Chemical Carcinogenesis
ISBN: 3540095845 ISBN-13(EAN): 9783540095842
Издательство: Springer
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Цена: 18167.00 р.
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Описание: N-nitroso-compounds form an important class of carcinogenic chemicals which may be of environmental importance (Druckrey et al., 1967; Magee et al., 1976; IARC, 1978). The mechanism by which these carcinogens initiate neoplastic growth is not well understood but there is substantial evidence favoring the hypothesis that the simple dialkylnitrosamines and alkylnitrosamides act by means of their conversion to al- kylating agents. Alkylating species are generated from the nitrosamines by metabolic activation and from the nitrosamides by chemical decomposition at physiological pH. It is widely believed that DNA is the critical alkylation target. Alkylation takes place at at least 12 sites within the DNA molecule (Lawley, 1976; Singer, 1976; Pegg, 1977a). Al- though alkylation at the 7-position of guanine is the most extensive reaction with the DNA bases and provides a reliable measurement of the degree of interaction with the carcinogen (Swann and Magee, 1968, 1971), recent experiments have suggested that alkylation of oxygen atoms may be the critical reaction (Goth and Rajewsky, 1974; Margison and Kleihues, 1975; Nicoll et aI., 1975; Pegg, 1977a). These laboratories have observed a correlation between the production and persistence of 06-alkyl- guanine and the occurrence oftumors in a variety of organs of rodents exposed to N-ni- troso-carcinogens. It has, therefore, been suggested that the ability of tissues to catalyze the removal of 06-alkylguanine from DNA may provide a protective mechanism against carcinogenesis.

Автор: Habib Zaidi
Название: Quantitative Analysis in Nuclear Medicine Imaging
ISBN: 1441936688 ISBN-13(EAN): 9781441936684
Издательство: Springer
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Цена: 14365.00 р.
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Описание: This book provides a review of image analysis techniques as they are applied in the field of diagnostic and therapeutic nuclear medicine.