Proteasomes: The World of Regulatory Proteolysis, Hilt, Wolfgang

Автор: Giovanni Abatangelo; Luigi Donati; Wolfgang Vansch
Название: Proteolysis in Wound Repair
ISBN: 354060815X ISBN-13(EAN): 9783540608158
Издательство: Springer
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Описание: As far as the repair process is concerned, a failure in such regulation may result in abnormal wound healing ranging from nonhealing wounds to hyper- trophic scarring. For example, the importance of debridement in nor- mal and especially in poorly healing wounds has become much clearer in the recent past.

Автор: Vladimir K. Antonov
Название: Chemistry of Proteolysis
ISBN: 3662009811 ISBN-13(EAN): 9783662009819
Издательство: Springer
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Описание: A first edition of this book appeared in Russian language in 1983. The book retains the presentation of the previous edition and yet enlarges the scope to cover the methods for site-directed mutagenesis of amide hydrolases, catalyti- cally active antibodies, etc.

Название: Proteostasis and proteolysis
ISBN: 0367499320 ISBN-13(EAN): 9780367499327
Издательство: Taylor&Francis
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Описание: Proteostasis integrates biological pathways controlling biogenesis, trafficking, folding, and degradation of proteins. This book focuses on two protein breakdown/degradation processes (proteolysis), which are part of a normally functioning proteostatic system: the ubiquitin-proteasome system and autophagy.

Автор: Thibault Mayor; Gary Kleiger
Название: The Ubiquitin Proteasome System
ISBN: 1493993712 ISBN-13(EAN): 9781493993710
Издательство: Springer
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Описание: “This volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.?Thorough and authoritative, The Ubiquitin Proteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.

Автор: St?bler
Название: Modelling Proteasome Dynamics in a Bayesian Framework
ISBN: 3658201665 ISBN-13(EAN): 9783658201661
Издательство: Springer
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Описание: Sabine Stubler compares different proteasome isoforms and subtypes in terms of their transport and active site-related parameters applying an existing computational model.

Автор: Mayor
Название: The Ubiquitin Proteasome System
ISBN: 1493987054 ISBN-13(EAN): 9781493987054
Издательство: Springer
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Цена: 18167.00 р.
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Описание: “This volume explores numerous techniques used to study the ubiquitin proteasome system. The chapters in this book are organized into five parts and cover topics such as determining the mechanisms of action for E2s, E3s, and DUB enzymes; the latest advances to study the formation of poly-ubiquitin chains as well as their linkage types; the binding partners of proteins in the UPS; methods for structure determination by x-ray crystallography, cryo electron microscopy and SAXS; screening assays to select for degrons or modulators of E3s and DUBs; proteomics approaches in the ubiquitin field and methods to study 26S proteasome function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, The Ubiquitin Proteasome System: Methods and Protocols is a valuable resource for both experienced and novice scientists who are interested in expanding their knowledge in this field.

Автор: Cam Patterson; Douglas M. Cyr
Название: Ubiquitin-Proteasome Protocols
ISBN: 1617374539 ISBN-13(EAN): 9781617374531
Издательство: Springer
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Цена: 20263.00 р.
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Описание: State-of-the-art and user-friendly, Ubiquitin-Proteasome Protocols offers novice and experienced bench scientists alike a thorough compendium of readily reproducible techniques that will accelerate discovery, enhance productivity, and permit manipulation of the system for varied research purposes.

Автор: David A. Dougan
Название: Regulated Proteolysis in Microorganisms
ISBN: 9400759398 ISBN-13(EAN): 9789400759398
Издательство: Springer
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Описание: This book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Baker`s yeast Saccharomyces cerevisiae).

Автор: Borivoj Keil
Название: Specificity of Proteolysis
ISBN: 3642483828 ISBN-13(EAN): 9783642483820
Издательство: Springer
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Описание: Specificity of Proteolysis presents a survey and conclusionson the action or proteinases - enzymes which are cleavingproteins or peptides. Whenever one is lookingfor an enzyme to act at a defined site or to give definedcleavage products one will find comprehensive information inthis work.

Автор: Jelena Radosavljevic
Название: A Closer Look at Proteolysis
ISBN: 1536186775 ISBN-13(EAN): 9781536186772
Издательство: Nova Science
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Цена: 32312.00 р.
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Описание: The book "A closer look at proteolysis" is conceived as a review of modern knowledge from various fields related to proteolytic processes. Due to the simple approach to explaining various aspects of the topics related to proteolysis, it will be of interest to a wide audience, as well for the scientific community. The first chapter provides an overview of basic concepts related to proteolysis, and the classification of proteases with an emphasis on proteases that have been identified as key in various pathophysiological conditions. After that, in the second chapter, the reader is introduced to proteases that participate in the development of malignancy. The proteases that are perceived as potential candidates for the development of anticancer treatments are highlighted. The third chapter provides an insight into the basics of intracellular proteolysis, with an emphasis on proteolysis of the intrinsically disordered proteins and the consequences that proteolysis of these proteins has in plant cells particularly. In the fourth chapter, the authors provide the latest knowledge on the possibility of using a standard protease for mass spectrometry to determine post-translational modifications of proteins, which is the most recent challenge in proteomics-based research. Although often used as therapeutics, peptides and proteins are susceptible to proteolysis under physiological conditions, so the design of drugs that mimic the action of proteins and peptides is a big challenge for medicinal chemists. In the fifth chapter, the authors elaborate on the ways to overcome proteolysis in potential therapeutic agents, using the rational design of modern peptidomimetics. The authors of the sixth chapter look at the correlation between the stability to proteolytic digestion and the allergenicity of food proteins. Chapters seven and eight are devoted to microbial proteases. The author of the seventh chapter gives an overview of the yeast proteases characterized so far, while the authors of the eighth chapter consider the possibilities for the production of purification of Bacillus proteases and their application in various biotechnological processes. In the last, ninth chapter, the technological significance of proteolytic processes in the food industry is emphasized. The authors presented methodologies that can be used to determine different bioactive peptides produced during cheese ripening.

Автор: David A. Dougan
Название: Regulated Proteolysis in Microorganisms
ISBN: 9401783667 ISBN-13(EAN): 9789401783668
Издательство: Springer
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Цена: 22201.00 р.
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Описание: This book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Baker s yeast Saccharomyces cerevisiae)."

Автор: C. M. Camargo, Beatriz L. Fernandes, Lilian Cruz
Название: Bioactive Peptides Produced by Limited Proteolysis
ISBN: 1615043683 ISBN-13(EAN): 9781615043682
Издательство: Mare Nostrum (Eurospan)
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Описание: Proteins are considered supremely important for the organization, survival, and functioning of living organisms. They were considered stable and static molecules until the early 1940s, when Rudolph Schoenheimer demonstrated that proteins exist in a constant dynamic process of synthesis and degradation (proteostasis), absolutely essential for life. Since then, general and limited protein degradation became some of the most fascinating aspects of biological sciences. This book is focused on a particular aspect of protein degradation, namely, limited proteolysis, which gives rise to bioactive peptides as a result of the enzymatic action of proteinases and peptidases, which are enzymes that hydrolyze specific peptide bonds of proteins and peptides, respectively. In a broad sense, bioactive peptides are any fragment of endogenous or exogenous proteins able to elicit either physiological or pathological activities. Here, we aim at presenting to the readers that bioactive peptides are not merely produced through random processes during protein degradation, but rather through a well-organized enzymatic process that is deeply integrated in the homeostatic processes of living organisms.