Molecular Mechanisms of Cardiac Hypertrophy and Failure, Walsh, Richard A.
Автор: Pecorino, Lauren Название: Molecular Biology of Cancer ISBN: 0198833024 ISBN-13(EAN): 9780198833024 Издательство: Oxford Academ Рейтинг: Цена: 11191.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.
Автор: Pecorino Lauren Название: Molecular Biology of Cancer ISBN: 0198717342 ISBN-13(EAN): 9780198717348 Издательство: Oxford Academ Рейтинг: Цена: 7126.00 р. Наличие на складе: Поставка под заказ.
Описание: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers the most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear.
Автор: Maulik Название: Molecular mechanisms and physiology of disease ISBN: 1493907050 ISBN-13(EAN): 9781493907052 Издательство: Springer Рейтинг: Цена: 32142.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.
Автор: Konrad Beyreuther; Gotthard Schettler Название: Molecular Mechanisms of Aging ISBN: 354052732X ISBN-13(EAN): 9783540527329 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A high-level text on the molecular and genetic aspects of human ageing with reference to cognitive functions and age-related diseases.
Автор: Walsh, Richard A. Название: Molecular Mechanisms of Cardiac Hypertrophy and Failure ISBN: 0367391627 ISBN-13(EAN): 9780367391621 Издательство: Taylor&Francis Рейтинг: Цена: 9492.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This title reviews current knowledge of the mechanisms contributing to heart failure. Editor Richard Walsh and an internationally renowned team of contributors discuss key advances in molecular and cell biology, biochemistry, and pharmacology, focusing on advances that have a direct bearing on current clinical studies. It highlights developments across a broad range of disciplines, with in-depth coverage of each topic providing background and perspective on current literature. By setting new advances in a broader context, this text allows readers to compare different ideas and evaluate their importance in their own areas of research or clinical practice.
Автор: Michael N. Alexis; Constantin E. Sekeris Название: Activation of Hormone and Growth Factor Receptors ISBN: 0792305736 ISBN-13(EAN): 9780792305736 Издательство: Springer Рейтинг: Цена: 36756.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Proceedings of the NATO Advanced Research Workshop, Nafplion, Greece, September 25-30, 1988
Автор: Michel Lebel Название: Molecular Mechanisms of Werner`s Syndrome ISBN: 0306482339 ISBN-13(EAN): 9780306482335 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: During our short time on earth, we all undergo the highly complex process of aging, and with it, we experience the many physiological symptoms. Studies of premature aging have produced a deal of information that gives some aspects of aging a better understanding. This book explores Werner`s syndrome.
Автор: Nilanjana Maulik; Tom Karagiannis Название: Molecular mechanisms and physiology of disease ISBN: 1493946234 ISBN-13(EAN): 9781493946235 Издательство: Springer Рейтинг: Цена: 32142.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.
Автор: Cl?vio N?brega; Raquel Rodriguez-L?pez Название: Molecular Mechanisms Underpinning the Development of Obesity ISBN: 3319376292 ISBN-13(EAN): 9783319376295 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Challenges in understanding development of obesity.- Monogenic forms of obesity.- Heterogeneous obesity syndromes: new strategies for diagnosis.- Genetic contribution: common forms of obesity.- The role of the GWAS identified FTO locus in regulating body size and composition.- Neural vulnerability factors that increase risk for weight gain: prevention and treatment implications.- Molecular mechanisms involved in the regulation of food intake.- Epigenetics of human obesity: a link between genetics and nutrition.- MicroRNAs in obesity and metabolism.- Obesity study: animal models.- From Homo obesus to Homo diabesus: neuroadipology insight.- Obesity and type 2 diabetes.
Автор: Eishi Noguchi; Mariana C. Gadaleta Название: Cell Cycle Control ISBN: 1493908871 ISBN-13(EAN): 9781493908875 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A collection of new reviews and protocols from leading experts in cell cycle regulation, Cell Cycle Control: Mechanisms and Protocols, Second Edition presents a comprehensive guide to recent technical and theoretical advancements in the field.
Описание: This book will serve as the preeminent text book on the topic of "base excision repair", a key DNA repair pathway that protects cells from most spontaneous forms of DNA damage, including oxidative lesions that arise both in the nuclear and mitochondrial genomes.
Автор: Walsh Название: Antibiotics: Challenges, Mechanisms, Opportunities ISBN: 1555819303 ISBN-13(EAN): 9781555819309 Издательство: Wiley Рейтинг: Цена: 16466.00 р. Наличие на складе: Поставка под заказ.
Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
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