Molecular Mechanisms of Metabolic Arrest, Storey, K.B.
Автор: Pecorino, Lauren Название: Molecular Biology of Cancer ISBN: 0198833024 ISBN-13(EAN): 9780198833024 Издательство: Oxford Academ Рейтинг: Цена: 11191.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students.
Автор: Pecorino Lauren Название: Molecular Biology of Cancer ISBN: 0198717342 ISBN-13(EAN): 9780198717348 Издательство: Oxford Academ Рейтинг: Цена: 7126.00 р. Наличие на складе: Поставка под заказ.
Описание: Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers the most engaging and accessible account of cancer biology that makes the link between our understanding of cancer and the development of new therapeutics crystal clear.
Автор: Walsh Название: Antibiotics: Challenges, Mechanisms, Opportunities ISBN: 1555819303 ISBN-13(EAN): 9781555819309 Издательство: Wiley Рейтинг: Цена: 16466.00 р. Наличие на складе: Поставка под заказ.
Описание: Antibiotics: Challenges, Mechanisms, Opportunities details the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibiotics is a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers. A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: • What are antibiotics? • Where do antibiotics come from?• How do antibiotics work? • Why do antibiotics stop working? • How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Автор: Maulik Название: Molecular mechanisms and physiology of disease ISBN: 1493907050 ISBN-13(EAN): 9781493907052 Издательство: Springer Рейтинг: Цена: 32142.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.
Автор: Weber Georg F Название: Molecular Mechanisms of Cancer ISBN: 9048175054 ISBN-13(EAN): 9789048175055 Издательство: Springer Рейтинг: Цена: 14365.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers.
Автор: Turan Belma Название: Diabetic Cardiomyopathy ISBN: 1461493161 ISBN-13(EAN): 9781461493167 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Diabetic Cardiomyopathy
Автор: Mark G. H. Scott; St?phane A. Laporte Название: Beta-Arrestins ISBN: 1493991574 ISBN-13(EAN): 9781493991570 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume looks at various approaches to study the pleiotropic roles of b-arrestins (b-arrs) in the control of signal transduction, and the resulting cellular and in vivo consequences that arise. The chapters in this book cover diverse topics around b-arrs such as their established roles in GPCR regulation and trafficking; regulatory scaffolding functions of b-arrs in MAPK signaling, cAMP hydrolysis and cytoskeletal dynamics; proteomic analysis of the b-arr interactome; mathematical modelling of b-arr signaling networks; functional selectivity involving biased ligands; nucleocytoplasmic trafficking and primary cilia-associated functions of b-arrs; conformational plasticity of b-arrs; and the roles of b-arrs in allergic inflammation, Type 2 Diabetes, Parkinson’s disease, and cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Cutting-edge and authoritative, Beta-Arrestins: Methods and Protocols is a valuable resource for researchers interested in learning more about the function and regulation of b-arrestins.
Автор: Luttrell,Louis M. Название: The Molecular Biology Of Arrestins,118 ISBN: 0123944406 ISBN-13(EAN): 9780123944405 Издательство: Elsevier Science Рейтинг: Цена: 19875.00 р. Наличие на складе: Поставка под заказ.
Автор: Vsevolod V. Gurevich Название: Arrestins - Pharmacology and Therapeutic Potential ISBN: 3642411983 ISBN-13(EAN): 9783642411984 Издательство: Springer Рейтинг: Цена: 43100.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume in Springer`s authoritative series on experimental pharmacology covers the molecular mechanisms and therapeutic implications of arrestin-mediated signaling, including the potential of re-engineered signaling proteins in the field of gene therapy.
Автор: Philip Hanawalt Название: Molecular Mechanisms for Repair of DNA ISBN: 1468429000 ISBN-13(EAN): 9781468429008 Издательство: Springer Рейтинг: Цена: 13974.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient.
Автор: Linda L. Gallo Название: Cardiovascular Disease ISBN: 1468452983 ISBN-13(EAN): 9781468452983 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Goldstein describe mutations in the LDL receptor that reveal the functions of its various domains and point out how understanding the LDL receptor has provided a rational basis for its regulation.
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