Описание: Alzheimer's is swiftly on the rise: it is estimated that every 67 seconds, someone develops the disease. For many, the words "Alzheimer's disease" or "dementia" immediately denote severe mental loss and, perhaps, madness. Indeed, the vast majority of media coverage of Alzheimer's disease (AD) and other types of dementia focuses primarily on the losses experienced by people diagnosed and the terrible burden felt by care partners yearning for a "magic bullet" drug cure. Providing an accessible, question-and-answer-format primer on what touches so many lives, and yet so few of us understand, Alzheimer's Disease and Dementia: What Everyone Needs to Know(R)contributes what is urgently missing from public knowledge: unsparing investigation of their causes and manifestations, and focus on the strengths possessed by people diagnosed. Steven R. Sabat mines a large body of research to convey the genetic and biological aspects of Alzheimer's disease, its clinical history, and, most significantly, to reveal the subjective experience of those with Alzheimer's or dementia. By clarifying the terms surrounding dementia and Alzheimer's, which are two distinct conditions, Sabat corrects dangerous misconceptions that plague our understanding of memory dysfunction and many other significant abilities that people with AD and dementia possess even in the moderate to severe stages. People diagnosed with AD retain awareness, thinking ability, and sense of self; crucially, Sabat demonstrates that there are ways to facilitate communication even when the person with AD has great difficulty finding the words he or she wants to use. From years spent exploring and observing the points of view and experiences of people diagnosed, Sabat strives to inform as well as to remind readers of the respect and empathy owed to those diagnosed and living with dementia. Alzheimer's Disease and Dementia conveys this type of information and more, which, when applied by family and professional caregivers, will help improve the quality of life of those diagnosed as well as of those who provide support and care.
Автор: Andrews, June Название: Dementia ISBN: 1788165055 ISBN-13(EAN): 9781788165051 Издательство: Profile Рейтинг: Цена: 1668.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: A world expert brings her advice up to date.
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 17149.00 р. 24499.00-30% Наличие на складе: Есть (1 шт.) Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Автор: Erik D. Roberson Название: Alzheimer`s Disease and Frontotemporal Dementia ISBN: 1493957007 ISBN-13(EAN): 9781493957002 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Alzheimer`s disease and frontotemporal dementia, two of the most prevalent neurodegenerative diseases, are dreaded disorders that attack the neural networks underlying memory and personality, systems that make us who we are.
Автор: Sangram S. Sisodia; Rudolph E. Tanzi Название: Alzheimer`s Disease ISBN: 1441941959 ISBN-13(EAN): 9781441941954 Издательство: Springer Рейтинг: Цена: 25853.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years.
Автор: Rudy Castellani, George Perry Название: Molecular Pathology of Alzheimer`s Disease ISBN: 1615046380 ISBN-13(EAN): 9781615046386 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 9286.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Alzheimer’s Disease is characterized pathologically by two principal hallmark lesions: the senile plaque and the neurofibrillary tangle. Since the identification of each over 100 years ago, the major protein components have been elucidated. This has led in turn to the elaboration of metabolic cascades involving amyloid-? production in the case of the senile plaque, and phosphorylated-tau protein in the case of the neurofibrillary tangle. The pathogenesis and histogenesis of each have been the source of extensive investigation and some controversy in recent years, as both cascades have been implicated in the pathogenesis of Alzheimer’s Disease, relied upon in the diagnostic criteria for Alzheimer’s Disease at autopsy, and targeted for therapeutic intervention. With the accumulation of data and expansion of knowledge of the molecular biology of Alzheimer’s Disease, it appears that the enthusiasm for successful intervention has been premature. In this book, we detail the discovery and characterization of the major pathological lesions, their associated molecular biology, their relationship to clinical disease, and potential fundamental errors in understanding that may be leading scientific investigators in unintended directions.
Автор: Heiko Braak; Kelly Del Tredici Название: Neuroanatomy and Pathology of Sporadic Alzheimer`s Disease ISBN: 3319126784 ISBN-13(EAN): 9783319126784 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail
Автор: Don Kulasiri, Jingyi Liang Название: Alzheimer`s Disease: Biology, Biophysics And Computational Models ISBN: 1800610114 ISBN-13(EAN): 9781800610118 Издательство: World Scientific Publishing Рейтинг: Цена: 22968.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Alzheimer's disease (AD) is the leading cause of dementia and, unfortunately, remains incurable. The social, emotional and financial implications of AD are immeasurable, and about 47 million people worldwide are affected by AD or other forms of dementia. As lifespans are improved by healthcare systems worldwide, age-associated neurodegenerative diseases are imposing an increasing challenge to science. It is becoming imperative for us to understand the causes of these diseases, AD in particular, at molecular and cellular levels. Starting with the broader picture from a biological perspective, this book takes the reader through fascinating dynamics within and outside of neurons in the brain.
Alzheimer's Disease: Biology, Biophysics and Computational Models helps the reader to understand AD from mechanistic and biochemical perspectives at intra- and inter-cellular levels. It focuses on biochemical pathways and modeling associated with AD. Some of the recent research on biophysics and computational models related to AD are explained using context-driven computational and mathematical modeling and essential biology is discussed to understand the modeling research.
Автор: Precious Название: Huntington`s Disease ISBN: 1493978241 ISBN-13(EAN): 9781493978243 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic process at the fundamental molecular and cellular level can the research community expect to be able to slow or halt the disease process, repair the damage, and develop novel effective therapies to treat the symptoms of this condition, thus this volume collects the practical knowledge of its authors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.
Автор: J. Winny Yun, J. Steven Alexander Название: The Lymphatic System in Health and Disease ISBN: 1615047913 ISBN-13(EAN): 9781615047918 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 5637.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The lymphatic system develops and functions in parallel with the blood circulatory system (termed the ""hemovasculature"") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens—providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar.This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.
Автор: J. Winny Yun, J. Steven Alexander Название: The Lymphatic System in Health and Disease ISBN: 161504793X ISBN-13(EAN): 9781615047932 Издательство: Mare Nostrum (Eurospan) Рейтинг: Цена: 8145.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The lymphatic system develops and functions in parallel with the blood circulatory system (termed the ""hemovasculature"") and accomplishes transport of interstitial fluids, dietary lipids, and reverse transport of cholesterol, immune cells, and antigens—providing a critical homeostatic fluid balance and transmission of immune cells and mediators back to the cardiovascular system. Although the daily flow of lymph (normally 1-2 L/day under unstressed conditions) is far lower than that of daily blood flow (which is 7,500 L/day), without the adequate functioning of the lymphatics, virtually all organs and tissues would acutely suffer many different physical and inflammatory stresses ranging from edema to organ system failure. Although blood and lymphatic vessels often form in anatomic parallels to one another, our knowledge of the workings of the lymphatic system, the fine structure of lymphatic networks, how they function in different organs, and how they are regulated physiologically and immunologically are far from parallel; our knowledge of the lymphatic system still remains at only a tiny fraction of what is understood about the cardiovascular system. Although both the cardiovascular and lymphatic systems are important transport systems, what they transport and how they transport and propel these very different cargoes could not be more dissimilar.This book provides an overview of the history of the discovery (and re-discovery) of the components of the lymphatic system, lymphatic anatomy, physiological functions of lymphatics, molecular features of the lymphatic system, and clinical perspectives involving lymphatics which may be of interest to scientists, clinicians, patients, and the lay public. We provide a current understanding of some of the more important structural similarities and differences between lymphatics and the blood vascular system, their coordinated control by angiogenic and hemangiogenic growth factors and other modulators, the fate and lineage determinants which control lymphatic development, and the roles that lymphatics may play in several different diseases.
Автор: Dieter Haussinger, Verena Keitel, Ralf Kubitz Название: Hepatobiliary Transport in Health and Disease ISBN: 3110278995 ISBN-13(EAN): 9783110278996 Издательство: Walter de Gruyter Рейтинг: Цена: 29744.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The transport systems involved in hepatobiliary transport have been cloned and characterized at the molecular level and it is becoming clear that mutations and polymorphisms of individual transporter molecules underlie a variety of liver diseases.
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