This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.
The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.
This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.
Автор: Dureja, Harish Название: Drug Delivery Systems For Metabolic Disorders ISBN: 0323996167 ISBN-13(EAN): 9780323996167 Издательство: Elsevier Science Рейтинг: Цена: 26107.00 р. Наличие на складе: Поставка под заказ.
Описание: Featuring the elegant and fully revised New Revised Standard Version, Updated Edition (NRSVue) text with Apocrypha, the NRSVue Holy Bible with Apocrypha, Premier Collection, delivers a smooth reading experience that complements the translation vetted by an ecumenical group of Christian scholars in a readable and handy personal size.
Описание: Chapter 1. Introduction.- Chapter 2. Synthetic Strategies for the Generation of Molecularly Imprinted Polymers.- Chapter 3. Special Control by Molecular Imprinting Materials-zero-order Sustained Release, Enantioselective MIPs and Self-regulated Drug Delivery Microdevices.- Chapter 4. Water Compatible Molecularly Imprinted Polymers.- Chapter 5. Stimuli Responsive Imprinted DDS.- Chapter 6. MIP as Drug Delivery Systems for Dermal Delivery.- Chapter 7. MIP as Drug Delivery Systems of Anticancer Agents.- Chapter 8. MIP as Dug Delivery Systems of Ophthalmic Drugs.- Chapter 9. MIP as Drug Delivery Systems for Special Application.- Chapter 10. Outlook.
Автор: Rolland, Alain Название: Advanced Gene Delivery ISBN: 9057024381 ISBN-13(EAN): 9789057024382 Издательство: Taylor&Francis Рейтинг: Цена: 35218.00 р. Наличие на складе: Поставка под заказ.
Автор: Clark Penelope Название: Colonic Disorders: Recent Researches ISBN: 1632410915 ISBN-13(EAN): 9781632410917 Издательство: Неизвестно Цена: 20108.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book provides substantial update on the recent researches in colonic disorders. The 21st century has witnessed a revival of research of the gastronomical tract, particularly since it was discovered that it has a primary role as an immune system organ
Автор: Richard Reilly Название: Fiber Deficiency and Colonic Disorders ISBN: 1468421743 ISBN-13(EAN): 9781468421743 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Epidemiologists, on the basis of studies carried out chiefly in Africa, have suggested that depletion of fiber in the modern Western diet affects health adversely.
Автор: Tursi Название: Colonic Diverticular Disease ISBN: 3030937631 ISBN-13(EAN): 9783030937638 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Поставка под заказ.
Описание: The book provides up-to-date information on all aspects of colonic diverticular disease, particularly common in Western countries. Most people suffering from it remain asymptomatic, while about 20% develop symptoms without complications, experiencing the so-called "Symptomatic Non-Complicated Diverticular Disease" (SUDD). 10-25% of this last group eventually develop diverticulitis, with or without complications. The incidence of diverticulitis and diverticular colon disease is increasing worldwide, and is becoming a significant burden for national health systems in terms of direct and indirect costs, also because its prevalence increases with age. Unfortunately, the disease pathogenesis is relatively unknown and several aetiological factors may play a role in its onset. The first parts of the book will deal with the disease epidemiology and etiopathogenesis, focusing on the roles of inflammation and dysbiosis as part of the pathophysiology of diverticular disease. The clinical spectrum, the diagnostic approach and differential diagnosis, medical and surgical treatments are described in the following sections. Written by experts in the field, the volume will be a unique and valuable resource for all clinicians, residents, and physicians involved in the management of this disease.
Автор: Jean-Claude Givel; Neil James Mortensen; Bruno Roc Название: Anorectal and Colonic Diseases ISBN: 3662495767 ISBN-13(EAN): 9783662495766 Издательство: Springer Рейтинг: Цена: 52967.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This fully revised new edition focuses on the clinical, diagnostic, and therapeutic aspects of conditions encountered by the coloproctologist and gastroenterological surgeon, who are faced with an increasing number of precise and specific treatment modalities.
Описание: This book summarizes the recent advancements for drug delivery systems (DDS) in terms of fundamental principles, rapidly emerging techniques and developing frontiers of molecular imprinting. Especially with the combination of enantioselective molecularly imprinted polymers and water compatible molecularly imprinted polymers, stimuli responsive imprinted DDS have been innovated and applied to dermal delivery, ophthalmic drugs and cancer treatment. This philosophy comprehensively revolutionizes the treatment strategy of human healthcare and provides the possibility to re-trigger in vivo an exhaust system after the complete release of the starting drug cargo, thus enabling precision medicine. To this end, the following unique features will be discussed and concluded: 1) State-of-the-art definition of MIP as drug delivery systems. 2) Advanced techniques and clinical applications of MIP as drug delivery systems in the past decade. 3) Novel frontiers and brand-new technologies, for example, drug delivery devices for zero-order sustained release and stimuli responsive imprinted DDS. 4) Revolutionary impact on dermal delivery, ophthalmic drugs and cancer treatment. 5) Future challenges and perspectives
Автор: Jaime Ruiz-Tovar Название: Diverticular Disease: Colonic Epidemy of the 21st Century ISBN: 1536159891 ISBN-13(EAN): 9781536159899 Издательство: Nova Science Рейтинг: Цена: 11562.00 р. Наличие на складе: Невозможна поставка.
Описание: Diverticular disease is one of the most common problems encountered by gastroenterologists, emergency physicians and surgeons, with a higher prevalence in elderly patients and a dramatic rising of incidences in young people, which involve an increase in health care costs, according to ambulatory visits and hospital admissions. Acute diverticulitis, the most important complication of diverticular disease, has a broad spectrum of severity, which involves many treatment options, ranging from outpatient-based antibiotic treatment, or even isolated nonsteroidal anti-inflammatory drugs, to parenteral antibiotic regimen, percutaneous drainage or surgery (lavage and drainage, Hartmann procedure or resection with anastomosis with or without a diverting stoma). The American Society of Colon and Rectal Surgeons recommended in their guidelines a routine follow-up colonoscopy after recovery from an acute episode to rule out malignancy, which is being re-evaluated in recent studies, including the alternative CT-colonography, especially in cases of incomplete colonoscopy or in high-risk patients. After an episode of acute diverticulitis, there is a significant risk of recurrence and a negative impact on quality of life. In order to decrease it, there are many treatments that are being evaluated such as fiber-rich diet, mesalazine, rifaximin, probiotics and elective colon resection, which should be decided individually. The aim of this book is to revise the current evidence about the diverticular disease and acute diverticulitis.
Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index.
This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations.
Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer.
Описание: This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics.
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