Prostacyclin and Its Receptors, Helen Wise; Robert L. Jones

Автор: Rast
Название: Immune Receptors
ISBN: 1617791385 ISBN-13(EAN): 9781617791383
Издательство: Springer
Рейтинг:
Цена: 20263.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate these functions are at the front lines of both protective and regulative roles of the immune system.  In Immune Receptors: Methods and Protocols, expert researchers present a variety of experimental approaches to the characterization of immune receptors and the cell biology that mediates their functions.  These include imaging techniques that aim to understand receptor localization and trafficking, techniques to measure receptor-ligand interactions, strategies to identify novel ligands and methods to analyze downstream receptor signaling, as well as strategies for genomic and proteomic characterization of receptor repertoires. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immune Receptors: Methods and Protocols offers technical descriptions and protocols that will be useful both to investigators who are interested in carrying out these procedures and to those who seek a deeper understanding of the bench science that lies behind the immunology literature.

Автор: Nathalie Vergnolle; Michel Chignard
Название: Proteases and Their Receptors in Inflammation
ISBN: 3034803427 ISBN-13(EAN): 9783034803427
Издательство: Springer
Рейтинг:
Цена: 26120.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание:

Proteases are everywhere from prokaryotes to eukaryotes, from virus to bacteria and in all human tissues, playing a role in many biological functions. Among these functions, the inflammatory reaction is of particular interest. In inflamed tissues, proteases can have a microbial and/or host origin and are involved not only in tissue remodeling, but also in specific signaling to resident or inflammatory cells, thereby contributing to the innate immune response.

This volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response. Mechanisms involved in protease signaling to cells are presented, and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed. Finally, the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung, gastrointestinal tract, skin, joints, etc.).

"

Автор: Marta Filizola
Название: G Protein-Coupled Receptors - Modeling and Simulation
ISBN: 9400774222 ISBN-13(EAN): 9789400774223
Издательство: Springer
Рейтинг:
Цена: 22203.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses.

Автор: Anton G. Kutikhin; Arseniy E. Yuzhalin
Название: Genomics of Pattern Recognition Receptors
ISBN: 3034806876 ISBN-13(EAN): 9783034806879
Издательство: Springer
Рейтинг:
Цена: 20896.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book details the polymorphisms of genes encoding pattern recognition receptors (PRRs). Following a short description of the general role of PRRs in the immune system, coverage examines the structure and function of Toll-like and NOD-like receptors.

Автор: Fridman
Название: Discoidin Domain Receptors in Health and Disease
ISBN: 1493963813 ISBN-13(EAN): 9781493963812
Издательство: Springer
Рейтинг:
Цена: 23508.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis by acting on collagen sensors; transducing signals that regulate cell polarity, tissue morphogenesis, cell differentiation, and collagen deposition. DDRs play a key role in diseases that are characterized by dysfunction of the stromal component, which lead to abnormal collagen deposition and the resulting fibrotic response that disrupt normal organ function in disease of the cardiovascular system, lungs and kidneys, just to mention a few. In cancer, DDRs are hijacked by tumor and stromal cells to disrupt normal cell-collagen communication and initiate pro-oncogenic programs. Importantly, several cancer types exhibit DDR mutations, which are thought to alter receptor function, and contribute to cancer progression. Therefore, the strong causative association between altered RTK function and disease it is been translated today in the development of specific tyrosine kinase inhibitors targeting DDRs for various disease conditions. In spite of the accumulating evidence highlighting the importance of DDRs in health and diseases, there is still much to learn about these unique RTKs, as of today there is a lack in the medical literature of a book dedicated solely to DDRs. This is the first comprehensive volume dedicated to DDRs, which will fill a gap in the field and serve those interested in the scientific community to learn more about these important receptors in health and disease.

Автор: Reid Eric
Название: Investigation of Membrane-Located Receptors
ISBN: 1468446339 ISBN-13(EAN): 9781468446333
Издательство: Springer
Рейтинг:
Цена: 16979.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: But `Proceedings` are proverbially ephemeral material reflecting an array of solo performances, whereas this book is hopefully more like an orchestra`s performance, of classical together with new material. Related to receptor methodo- logy, receptor features and phenomena get due attention in the text.

Автор: Giuseppe Di Giovanni; Ennio Esposito; Vincenzo Di
Название: 5-HT2C Receptors in the Pathophysiology of CNS Disease
ISBN: 1617797200 ISBN-13(EAN): 9781617797200
Издательство: Springer
Рейтинг:
Цена: 36570.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Increased understanding of the 5-HT2c receptor may play a key role in the treatment of many central nervous system diseases ranging from eating disorders and Parkinson`s to Alzheimer`s and epilepsy. This is the first ever overview of 5-HT2c receptor research.

Автор: Kim Neve
Название: The Dopamine Receptors
ISBN: 1617796565 ISBN-13(EAN): 9781617796562
Издательство: Springer
Рейтинг:
Цена: 43184.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This revised book serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. There are new chapters on dopamine receptor-interacting proteins and on dopamine receptor oligomerization.

Автор: Tammy Kielian
Название: Toll-like Receptors: Roles in Infection and Neuropathology
ISBN: 3642269117 ISBN-13(EAN): 9783642269110
Издательство: Springer
Рейтинг:
Цена: 27950.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: This book highlights traditional roles for TLRs in infectious diseases of the CNS. It also discusses recently emerging roles for TLRs in non-infectious neurodegenerative diseases and the challenges faced in these models with identifying endogenous ligands.

Автор: Jeffrey K. Harrison; Nicholas W. Lukacs
Название: The Chemokine Receptors
ISBN: 1617377686 ISBN-13(EAN): 9781617377686
Издательство: Springer
Цена: 28732.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: G-protein coupled receptors (GPCRs) constitute a large superfamily of proteins that have been historically well represented as drug targets. As such, many of the volumes within The Receptors series have focused their attention on rec- tor subfamilies in the GPCR superfamily (e. g., adrenergic, serotonergic, do- minergic). While chemokine receptors are relatively young, in terms of the knowledge that has accumulated regarding their roles in physiology and pat- logy, it is clear that this GPCR subfamily is dwar? ng all others with respect to the total number of receptors and their functional diversity. The breadth of the chemokine ? eld was not fully appreciated in the early days of chemokine d- covery, when the characterization of these molecules was largely a curiosity of a small set of biologists primarily interested in in? ammation. Presently, the ? eld of chemokinology is quite diverse, and it is nearly impossible to stay informed on all aspects of chemokine biology. Nonetheless, this book seeks to distill information regarding the molecular and cell biology, physiology, and pathology of chemokines and their receptors into a single volume, providing an excellent resource for those entering the ? eld or the most experienced c- mokinologist seeking new insights. In the chapters, leading authorities consider structural and cellular aspects of chemokines and chemokine receptors, and more notably, discuss the roles of these molecules in a variety of disease states that transcend their classically de? ned role(s) in in? ammation.

Автор: Adam C. Errington; Giuseppe Di Giovanni; Vincenzo
Название: Extrasynaptic GABAA Receptors
ISBN: 1493914251 ISBN-13(EAN): 9781493914258
Издательство: Springer
Рейтинг:
Цена: 20962.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Автор: Marc Daeron; Falk Nimmerjahn
Название: Fc Receptors
ISBN: 3319079107 ISBN-13(EAN): 9783319079103
Издательство: Springer
Рейтинг:
Цена: 22359.00 р.
Наличие на складе: Есть у поставщика Поставка под заказ.

Описание: Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection.