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Genome Instability, Marco Muzi-Falconi; Grant W Brown


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Автор: Marco Muzi-Falconi; Grant W Brown
Название:  Genome Instability
ISBN: 9781493973057
Издательство: Springer
Классификация:


ISBN-10: 1493973053
Обложка/Формат: Hardcover
Страницы: 663
Вес: 1.38 кг.
Серия: Methods in Molecular Biology
Язык: English
Размер: 254 x 178 x 37
Основная тема: Biomedicine
Подзаголовок: Methods and Protocols
Ссылка на Издательство: Link
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Поставляется из: Германии
Описание:

1. The A-like Faker Assay for Measuring Yeast Chromosome III Stability

Carolina A. Novoa, J. Sidney Ang, and Peter C. Stirling

2. The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast

Supipi Duffy and Philip Hieter

3. Measuring Mutation Rates using the Luria-Delbrьck Fluctuation Assay

Gregory I. Lang

4. Molecular Genetic Characterization of Mutagenesis Using a Highly Sensitized Single-Stranded DNA Reporter System in Budding Yeast

Kin Chan

5. Analyzing Genome Rearrangements in Saccharomyces cerevisiae

Anjana Srivatsan, Christopher D. Putnam, and Richard D. Kolodner

6. High Resolution Mapping of Modified DNA Nucleobases using Excision Repair Enzymes

Monica Ransom, D. Suzi Bryan and Jay R. Hesselberth

7. Integrated Microarray-based Tools for Detection of Genomic DNA Damage and Repair Mechanisms

Patrick van Eijk, Yumin Teng, Mark R. Bennet, Katie E. Evans, James R. Powell, Richard M. Webster, and Simon H. Reed

8. Study of UV-induced DNA Repair Factor Recruitment: Kinetics and Dynamics

Sertic S., Roma S., Plevani P., Lazzaro F., and Muzi-Falconi M.

9. Inserting Site-specific DNA Lesions into Whole Genomes

Vincent Pagиs and Robert P Fuchs

10. A qPCR-based Protocol to Quantify DSB Resection

Matteo Ferrari, Shyam Twayana, Federica Marini, and Achille Pellicioli

11. Alkaline Denaturing Southern Blot Analysis to Monitor Double-strand Break Processing

Chiara Vittoria Colombo, Luca Menin, and Michela Clerici

12. Single Molecule Analysis of Resection Tracks

Pablo Huertas and Andrйs Cruz-Garcнa

13. Mapping DNA Breaks by Next-generation Sequencing

Laura Baranello, Fedor Kouzine, Damian Wojtowicz, Kairong Cui, Keji Zhao, Teresa M Przytycka, Giovanni Capranico, and David Levens

14. Genome-wide Profiling of DNA Double-strand Breaks by the BLESS and BLISS Methods

Reza Mirzazadeh, Tomasz Kallas, Magda Bienko, and Nicola Crosetto

15. DNA Replication Profiling using Deep Sequencing

Xanita Saayman, Cristina Ramos-Pйrez, and Grant W Brown

16. Quantitative Bromodeoxyuridine Immunoprecipitation Analyzed by High-Throughput Sequencing (qBrdU-seq or QBU)

Joanna E. Haye-Bertolozzi and Oscar M. Aparicio

17. Strand-specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast

Chuanhe Yu, Haiyun Gan, and Zhiguo Zhang

18. Analysis of Replicative Polymerase Usage by Ribonucleotide Incorporation

Andrea Keszthelyi, Izumi Miyabe, Katie Ptasińska, Yasukazu Daigaku, Karel Naiman, and Antony M. Carr

19. Dynamic Architecture of Eukaryotic DNA Replication Forks in vivo, Visualized by Electron Microscopy

Ralph Zellweger and Massimo Lopes

20. A Molecular Toolbox to Engineer Site-Specific DNA Replication Perturbation

Nicolai B. Larsen, Ian D. Hickson, and Hocine W. Mankouri

21. Single Cell Gel Electrophoresis for the Detection of Genomic Ribonucleotides

Barbara Kind, Christine Wolf, Kerstin Engel, Alexander Rapp, M. Cristina Cardoso, and Min Ae Lee-Kirsch

22. Measuring the Levels of Ribonucleotides Embedded in Genomic DNA

Meroni A., Nava G.M., Sertic S., Plevani P., Muzi-Falconi M. and Lazzaro F.

23. Mapping Ribonucleotides Incorporated into DNA by Hydrolytic End-Sequencing

Clinton D. Orebaugh, Scott A. Lujan, Adam B. Burkholder, Anders R Clausen, and Thomas A. Kunkel




Genomic Instability and Cancer Metastasis

Автор: Chris Maxwell; Cal Roskelley
Название: Genomic Instability and Cancer Metastasis
ISBN: 3319352954 ISBN-13(EAN): 9783319352954
Издательство: Springer
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Цена: 19589.00 р.
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Описание: Metastasis is the primary cause of mortality associated with cancer, and tumor genomic heterogeneity is a likely source for the cells that support cancer progression, resistance to therapy, and disease relapse.

Trinucleotide Diseases and Instability

Автор: Ben A. Oostra
Название: Trinucleotide Diseases and Instability
ISBN: 3662225654 ISBN-13(EAN): 9783662225653
Издательство: Springer
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Цена: 6986.00 р.
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Описание: Trinu- cleotide repeat diseases are ideal subjects for direct testing because the muta- tion is almost exclusively of the same type and there is an extremely low occur- ance of new mutations in these diseases.

Chromosomal Instability in Cancer Cells

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319202901 ISBN-13(EAN): 9783319202907
Издательство: Springer
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Цена: 11878.00 р.
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer. Cancer is a disease of the chromosomes, and chromosomal instability in cancer disrupts gene function by either inactivating tumor suppressor genes or activating growth-promoting oncogenes. The chromosomal basis for these aberrations is either translocations, which change the integrity of genes, or abnormal numbers of chromosomes, a condition referred to as aneuploidy, which results in abnormal gene expression levels. Such structural or numerical chromosomal aberrations are specific for distinct tumor entities. The degree of chromosomal instability and the degree of intratumor heterogeneity have profound consequences for disease outcome and for therapeutic stratification.

Genomic Instability and Immortality in Cancer

Автор: Enrico Mihich; Leland Hartwell
Название: Genomic Instability and Immortality in Cancer
ISBN: 1461374480 ISBN-13(EAN): 9781461374480
Издательство: Springer
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Описание: Proceedings of the Eighth Annual Pezcoller Symposium held in Trento, Italy, June 17-19, 1996

Chromosomal Instability in Cancer Cells

Автор: B. Michael Ghadimi; Thomas Ried
Название: Chromosomal Instability in Cancer Cells
ISBN: 3319349627 ISBN-13(EAN): 9783319349626
Издательство: Springer
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Цена: 11179.00 р.
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Описание: This issue of Recent Results in Cancer Research presents a comprehensive review of current understanding of chromosomal instability in cancer and of strategies to use this information for better treatment of patients with cancer.


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