Alzheimer`s Disease, J.D. Turner; K. Beyreuther; F. Theuring
Автор: Rudolph Название: Alzheimer`s Disease ISBN: 1439827087 ISBN-13(EAN): 9781439827086 Издательство: Taylor&Francis Рейтинг: Цена: 17149.00 р. 24499.00-30% Наличие на складе: Есть (1 шт.) Описание:
In recent years, a tremendous amount of effort has been focused on better understanding the fundamentals of Alzheimer's disease (AD) to facilitate early and accurate diagnosis and appropriately targeted therapeutic treatments. Alzheimer's Disease: Targets for New Clinical, Diagnostic, and Therapeutic Strategies provides a detailed synopsis of the current state of the art of diagnostics and therapeutics and identifies emerging technologies and molecules that show promise in the management and treatment of AD.
With contributions from experts drawn from academia, clinical practice, and the biotechnology and pharmaceutical industries, the book explores:
The basis of AD and the role of Aβ oligomers in development of disease
Existing and emerging in vitro biomarker-based methodologies for the diagnosis of AD, focusing on genetic, biochemical, and conformational strategies
In vivo imaging diagnostic approaches
Evolving diagnostic criteria, health regulatory guidelines, biomarkers in clinical trials, and available and emerging therapies
Recent progress in small-molecule disease-modifier drug discovery efforts for AD, specifically in the areas of Aβ, tau, and emerging neuroprotective/neurorepair approaches
How a case study of AD raises issues regarding clinical and pathologic criteria, risk factors, and the amyloid hypothesis
The molecular conformational factors that govern the pathogenicity of aggregating proteins, and how these factors could represent new targets for disease-modifying therapies
The latest epidemiological, pathological, biochemical, and behavioral studies that may shed some light on the risk of developing AD and similar dementias after traumatic brain injury
Examining current hypotheses and suggesting possible new approaches to therapeutic clinical applications, this volume paves the way for a robust pipeline of therapeutics to combat not only AD, but a whole host of other neurodegenerative diseases.
Автор: Verna Benner Carson; Katherine Johnson Vanderhorst Название: Care Giving for Alzheimer`s Disease ISBN: 1493924060 ISBN-13(EAN): 9781493924066 Издательство: Springer Рейтинг: Цена: 6986.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Going Back to the Beginning-The Theory of Retrogenesis.- There is No such Thing as a "Little Dementia".- If I Knew My Loved one was in Pain....-Dementia: Strips Individuals of All Skills.- Help! My Mother is Lost and I Can't Find Her.- Getting Food in....And Getting it Out.- Sexuality and Intimacy in those with Dementia.- Communication Commandments.- Whispering Hope and Faith: Still Small Voices for the Alzheimer's Journey.- What Else?...Keeping Good Records; Sundowning; Taking Away the Keys; Making Placement Decisions; Controlling the Money.- Thinking Outside of the Box - Joyce's Story.
Автор: Verna Benner Carson; Katherine Johnson Vanderhorst Название: Care Giving for Alzheimer`s Disease ISBN: 1493945270 ISBN-13(EAN): 9781493945276 Издательство: Springer Рейтинг: Цена: 8384.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Veteran clinicians offer a unique framework for understanding the psychological origins of behaviors typical of Alzheimer's and other dementias, and for providing appropriate care for patients as they decline. Guidelines are rooted in the theory of retrogenesis in dementia--that those with the condition regress in stages toward infancy--as well as knowledge of associated brain damage. The objective is to meet patients where they are developmentally to best be able to address the tasks of their daily lives, from eating and toileting to preventing falls and wandering. This accessible information gives readers a platform for creating strategies that are respectful, sensitive, and tailored to individual needs, thus avoiding problems that result when care is ineffective or counterproductive. Featured in the coverage: * Abilities and disabilities during the different stages of Alzheimer's disease. * Strategies for keeping the patient's finances safe. * Pain in those with dementia, and why it is frequently ignored. * "Help! I've lost my mother and can't find her!" * Sexuality and intimacy in persons with dementia. * Instructive vignettes of successful caring interventions. Given the projected numbers of individuals expected to develop dementing conditions, Care Giving for Alzheimer’s Disease will find immediate interest among clinical psychologists, health psychologists, psychiatrists, social workers, and primary care physicians.
Автор: Kurt A. Jellinger; Gernot Ladurner; Manfred Windis Название: New Trends in the Diagnosis and Therapy of Alzheimer`s Disease ISBN: 3211826203 ISBN-13(EAN): 9783211826201 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Based on the 2nd International Symposium on EBEWE Research Initiative held in Salzburg, Austria, 1993, this book is a review of the current knowledge of morphology, diagnostic clinical and imaging techniques, and outcome variables and possibilities of therapy of AD and other neurodisorders.
Описание: Dementia of Alzheimer type (DAT), multiinfarct dementia (MID) and dementia occurring in the course of Parkinson's disease (PD +D) now make up one of the largest categories of chronic diseases in the elderly. In addition to the burden those illnesses impose on the affected individuals and their families they consume large socio-economic re- sources. In the light of all the above mentioned features, it seemed to us that a Symposium on behalf of the 125th Anniversary of Birth of Aloys Alzheimer was particularly well-suited to help to advance research on Alzheimer's disease and other dementias. This International Symposium combined with a Satellite Symposium about "Clinical Aspects of Alz- heimer Dementias" took place in June 1989 in Wiirzburg and has been organized by the Psychiatric Departments of the Universities of Wiirzburg and Munich (H. Beckmann, K. Maurer, P. Riederer, H. Hippius and H. Lauter) and the Department of Pathochemistry and General Neurochemistry of the University of Heidelberg (S. Hoyer). In the chapters which follow, thorough reviews of recognized authorities in the field of dementia are given in the four main fields of epidemiology, neuropathology, neurochemistry and clinics. This Symposium and the edition of this book would not have been possible without the generous support of E. Merck, Darmstadt. In particular we gratefully acknowledge the efforts undertaken by Mr. Hernandez-Meyer to organizing this symposium and to publish this book. Furthermore we are grateful to the secretarial help by Mrs. Moeslein, Miss Philipp and Miss Grabner.
Автор: Bradley T. Hyman; Jean-Francois Demonet Название: The Living Brain and Alzheimer`s Disease ISBN: 3642639275 ISBN-13(EAN): 9783642639272 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: From large cross-sectional studies of autopsy material, it seems as if a time course of Alzheimer`s Disease, at least on average, can be mapped out: a pattern of hierarchical vulnerability for neuronal loss and neurofibrillary tangles beginning in medial temporal lobe structures proceeding through association areas.
Environmental Causes for Alzheimer's Disease and Prevention Measures examines the increased incidence of the disease in developed countries and aims to educate neuroscientists, medical practitioners and other educated individuals on new insights into environmental causation, primarily metals. This book looks into the web of evidence around the hypothesis of copper toxicity and the additional role that a high fat diet plays in disease progression and cognition loss. The data and its implications are discussed, along with potential prevention measures. This book will generate excitement and interest among neuroscientists, medical practitioners and other biomedical researchers.
Emphasizes the history and epidemiology of Alzheimer's disease, highlighting its epidemic proportions in developed countries
Discusses data on new environmental factors in developed countries
Provides prevention measures to potentially reduce Alzheimer's rates through diet
Автор: Bradley T. Hyman; Charles Duyckaerts Название: Connections, Cognition and Alzheimer`s Disease ISBN: 3642645046 ISBN-13(EAN): 9783642645044 Издательство: Springer Рейтинг: Цена: 16979.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Steven G. Younkin; Rudolph E. Tanzi Название: Presenilins and Alzheimer`s Disease ISBN: 3642721052 ISBN-13(EAN): 9783642721052 Издательство: Springer Рейтинг: Цена: 19591.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The role of the familial Alzheimer`s Disease genes called "presenilins" in causing neuronal cell death and Alzheimer-related pathology.
Автор: Ken S. Kosik; Dennis J. Selkoe Название: Alzheimer`s Disease: Lessons from Cell Biology ISBN: 3642794254 ISBN-13(EAN): 9783642794254 Издательство: Springer Рейтинг: Цена: 20896.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer`s disease was descriptive, and lay in the province of pathologists.
Автор: Yoshikuni Mizuno; Abraham Fisher; Israel Hanin Название: Mapping the Progress of Alzheimer`s and Parkinson`s Disease ISBN: 1475709730 ISBN-13(EAN): 9781475709735 Издательство: Springer Рейтинг: Цена: 26122.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: 1h The 5 International Conference on the Progress in Alzheimer`s Disease and Parkinson`s 51 1 Disease took place from March 31 to April 5 \ 2001 in Kroto, Japan. This international 1 conference was organized as a joint Congress with the 9 International Catecholamine Symposium.
Автор: Kunal Roy Название: Computational Modeling of Drugs Against Alzheimer`s Disease ISBN: 1493974033 ISBN-13(EAN): 9781493974030 Издательство: Springer Рейтинг: Цена: 27950.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This volume describes different computational methods encompassing ligand-based approaches (QSAR, pharmcophore), structure-based approaches (homology modeling, docking, molecular dynamics simulation), and combined approaches (virtual screening) with applications in anti-Alzheimer drug design.
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