Metabotropic Glutamate Receptor Technologies, Olive M. Foster, Burrows Brian T., Leyrer-Jackson Jonna M.

Автор: P. Jeffrey Conn; Jitendra Patel
Название: The Metabotropic Glutamate Receptors
ISBN: 1617370061 ISBN-13(EAN): 9781617370069
Издательство: Springer
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Описание: It is the goal of The Metabotropic Glutamate Receptors to provide acomprehensive and forward-thinking review ofthe tremen- dous advances that have occurred in less than a decade of metabotropic glutamate receptors (mGluR) research. Virtually every areaof mGluR research is covered, including the molecular biology, pharmacology, anatomical distribution, and physiological and pathological roles of mGluRs. It is our intention that this volume not only summarize what is now known about the mGluRs, but also illuminate the areas in which there is the greatest need for focused research. Glutamic acid is an amino acid that has long been known to play several important metabolic roles in central and peripheral tissues and to be a component of several naturally occurring molecules. The first evidence that glutamate mayaIso serve as a neurotransmitter in the central nervous system (CNS) came in the late 1950s and early 1960s when glutamate and other acidic amino acids were found to induce behavioral convulsions when topically applied to the cortex and to excite a wide variety of central neurons. These findings spurred a massive research effort that quickly established glutamate as the pri- mary excitatory neurotransmitter in the vertebrate CNS. One of the most striking characteristics of glutamate that was quickly recognized was its ubiquitous role in serving as the neurotransmitter at the vast majority of excitatory synapses in the brain. It is now clear that most central neuronal circuits involve glutamatergic neurotransmission at some level.

Автор: Senthilkumar Rajagopal; Murugavel Ponnusamy
Название: Metabotropic GPCRs: TGR5 and P2Y Receptors in Health and Diseases
ISBN: 9811315701 ISBN-13(EAN): 9789811315701
Издательство: Springer
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Описание: This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members.

Автор: Gabriela K. Popescu
Название: Ionotropic Glutamate Receptor Technologies
ISBN: 1493928112 ISBN-13(EAN): 9781493928118
Издательство: Springer
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Цена: 20962.00 р.
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Описание: This detailed volume explores key technologies that are used currently to investigate iGluR structure, function and physiology.

Автор: Gabriela K. Popescu
Название: Ionotropic Glutamate Receptor Technologies
ISBN: 1493948954 ISBN-13(EAN): 9781493948956
Издательство: Springer
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Цена: 13275.00 р.
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Описание: This detailed volume explores key technologies that are used currently to investigate iGluR structure, function and physiology.

Автор: Daniel Monaghan; Robert Wenthold
Название: The Ionotropic Glutamate Receptors
ISBN: 1461284422 ISBN-13(EAN): 9781461284420
Издательство: Springer
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Цена: 32004.00 р.
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Описание: The field of the excitatory amino acids was born when L-glutamate and L-aspartate were found to be potent convulsants (Hayashi, 1954), and were subsequently found to excite neurons directly (Curtis, Phillis, and Watkins, 1959). Although these studies initiated the hypothesis of glutamate-mediated neurotransmission, it was noted that the ubiquitous actions of glutamate could also reflect a general, nonspecific property of glutamate on neuronal mem- branes. It was not until 20 years later that pharmacological, physiological, and biochemical studies provided convincing evidence for a neurotransmitter role for glutamate in the mammalian central nervous system (CNS). With the critical demonstration that the pharmacologically defined glutamate receptors mediate synaptic currents, glutamate rapidly became widely accepted as a majorneurotransmitter by the mid-1980s. This breakthrough, together with the simultaneous findings that glutamate receptors are involved in many essential, as well as pathological, processes in the CNS, instantly transformed the study of glutamate receptors into one of the fastest-growing and most exciting areas of neuroscience. With the cloning of numerous ionotropic glutamate receptor subunits over the last six years, the field has experienced another dramatic acceleration in the understanding of receptor action and in providing the first clear insights into the molecular bases underlying the wealth of pharmacological and physiological data on these receptors.

Автор: Peter Jonas; Hannah Monyer
Название: Ionotropic Glutamate Receptors in the CNS
ISBN: 3540661204 ISBN-13(EAN): 9783540661207
Издательство: Springer
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Описание: With contributions by numerous experts

Автор: Corinna Burger; Margaret Jo Velardo
Название: Glutamate Receptors
ISBN: 1493990764 ISBN-13(EAN): 9781493990764
Издательство: Springer
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Цена: 22359.00 р.
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Описание:

Preface...
Table of Contents...
Contributing Authors...

Part I Synaptic Ultrastructure/Receptor Dynamics/Receptor Interactions and Trafficking

1. Single Molecule FRET Methods to Study Glutamate Receptors
Douglas Litwin, Ryan Durham, and Vasanthi Jayaraman

2. Ultrastructural Observation of Glutamatergic Synapses by Focused Ion Beam Scanning Electron Microscopy (FIB/SEM)
Ai Takahashi, Laxmi Kumar Parajuli, Hirohide Iwasaki, Shinji Tanaka, and Shigeo Okabe

3. Considerations for Imaging and Analyzing Neural Structures by STED Microscopy
Martin O. Lenz and Jan T nnesen

4. Cell-Based Enzyme-Linked Immunosorbent Assay (Cell-ELISA) Analysis of Native and Recombinant Glutamate Receptors
Elek Molnбr

Part II Function/Cellular Plasticity

5. Preparation of Organotypic Slice Cultures for the Study of Glutamate Receptor Function
Andres Barria

6. Glutamate Receptor Probing with Rapid Application and Solution Exchange (RASE)
Nathanael O'Neil and Sergiy Sylantyev

7. Electrophysiological Investigation of Metabotropic Glutamate Receptor-Dependent Metaplasticity in the Hippocampus
Regina U. Hegemann and Wickliffe C. Abraham

8. Induction of Metabotropic Glutamate Receptor-Mediated Long-Term Depression in the Hippocampal Schaffer Collateral Pathway of Aging Rats
Kirstan E. Gimse, Kenneth O'Riordan, and Corinna Burger

9. Whole-Cell Patch Clamp Electrophysiology to Study Inotropic Glutamatergic Receptors and Their Roles in Addiction
Jonna M. Leyrer-Jackson, M. Foster Olive, and Cassandra D. Gipson

Part III Receptor Gene Regulation/Epigenetics

10. Gene Expression Analysis by Multiplex Single Cell RT-PCR
Tricoire Ludovic, Cauli Bruno, and Lambolez Bertrand

11. Metabolomics Analysis of Glutamate Receptor Function
Nataliya E. Chorna and Anatoliy P. Chornyy

12. Locus-Specific DNA Methylation Assays to Study Glutamate Receptor Regulation
Jordan A. Brown, J. David Sweatt, and Garrett A. Kaas

13. Preparation of Synaptoneurosomes for the Study of Glutamate Receptor Function
Cara J. Westmark and Pamela R. Westmark

Part VI Clinical Applications

14. Fractionation of Subcellular Compartments from Human Brain Tissue
Toni M. Mueller, Pitna Kim, and James H. Meador-Woodruff

15. Glutamate Receptor Antibodies in Autoimmune Central Nervous System Disease: Basic Mechanisms, Clinical Features, and Antibody Detection
WJ Scotton, Abid Karim, and Saiju Jacob

Автор: Robert W. Gereau; Geoffrey Swanson
Название: The Glutamate Receptors
ISBN: 1627039201 ISBN-13(EAN): 9781627039208
Издательство: Springer
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Описание: This insightful and comprehensive book covers nearly every aspect of glutamate receptor structure and function for the working researcher and student.

Автор: Philippe Ascher; Dennis W. Choi
Название: Glutamate, Cell Death and Memory
ISBN: 3642845282 ISBN-13(EAN): 9783642845284
Издательство: Springer
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Цена: 18167.00 р.
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Описание: As for the proceedings of the meeting on Alzheimer`s disease - published in the series Research and Perspectives in Alzheimer`s disease -these meetings will be reported in a new series, distributed at an international level, Research and Perspectives in Neurosciences.

Автор: Arne Schousboe; Ursula Sonnewald
Название: The Glutamate/GABA-Glutamine Cycle
ISBN: 3319450948 ISBN-13(EAN): 9783319450940
Издательство: Springer
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Цена: 23508.00 р.
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Описание: Fundamental biochemical studies of basic brain metabolism focusing on the neuroactive amino acids glutamate and GABA combined with the seminal observation that one of the key enzymes, glutamine synthetase is localized in astroglial cells but not in neurons resulted in the formulation of the term “The Glutamate-Glutamine Cycle.” In this cycle glutamate released from neurons is taken up by surrounding astrocytes, amidated by the action of glutamine synthetase to glutamine which can be transferred back to the neurons. The conversion of glutamate to glutamine is like a stealth technology, hiding the glutamate molecule which would be highly toxic to neurons due to its excitotoxic action. This series of reactions require the concerted and precise interaction of a number of enzymes and plasma membrane transporters, and this volume provides in-depth descriptions of these processes. Obviously such a series of complicated reactions may well be prone to malfunction and therefore neurological diseases are likely to be associated with such malfunction of the enzymes and transporters involved in the cycle. These aspects are also discussed in several chapters of the book.