The Immunology of Cardiovascular Homeostasis and Pathology, Sattler Susanne, Kennedy-Lydon Teresa
Автор: D.H. Wang Название: Molecular Sensors for Cardiovascular Homeostasis ISBN: 1489991999 ISBN-13(EAN): 9781489991997 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Biological homeostasis is maintained via intact function of an array of molecules detecting changes of microenvironments inside and outside of the biological system. These molecules, including cell membrane proteins and ion channels, are intimately involved in a variety of sensory pathways and respond to environmental stimuli, including altered temperature, pH, mechanical and osmotic stress, intra- and extracellular messengers, as well as changes in energy consumption. The book reveals the state-of-the-science of several newly discovered ion channel families and their role in the pathogenesis of cardiovascular diseases. This work offers comprehensive and up-to-date information for a deeper understanding of the relationship between macro- and micro-environments, ion channels, and pathophysiological responses, and for developing novel therapies for treating devastating cardiovascular illnesses.
Описание: The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases.There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.
Автор: Yamasaki Sho Название: C-Type Lectins in Immune Homeostasis ISBN: 3030622363 ISBN-13(EAN): 9783030622367 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book focuses on C-type lectin receptors, a newly emerging family of pattern-recognition receptors (PRRs) and a crucial part of the human innate immune system.
Автор: Susanne Sattler; Teresa Kennedy-Lydon Название: The Immunology of Cardiovascular Homeostasis and Pathology ISBN: 3319576119 ISBN-13(EAN): 9783319576114 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Preface Introduction Section 1: The Immune system in tissue and organ homeostasis Chapter 1: The Immune system beyond the fight against infection Section 2: Immune functions and properties of resident cells in the heart and cardiovascular system Chapter 2: Cardiomyocytes: Paying for the Tolls - The High Cost of the Innate Immune System for the Cardiac Myocyte Chapter 3: Fibroblasts: Properties and immune function of cardiac fibroblasts Chapter 4: Endothelial cells Chapter 5: Pericytes Chapter 6: Tissue-resident macrophages: The role of cardiac tissue macrophages in homeostasis and disease Section 3: The immune system in cardiovascular pathology Chapter 7: Atherosclerosis Chapter 8: Immune mediated heart disease Chapter 9: Vasculitis in the central nervous system Chapter 10: Cardiac Autoimmunity: Myocarditis Section 4: The immune system in repair and regeneration after myocardial infarct Chapter 11: Lymphocytes at the heart of wound healing Chapter 12: The innate immune system in cardiovascular repair and regeneration
Автор: Richard Bucala; J?rgen Bernhagen Название: MIF Family Cytokines in Innate Immunity and Homeostasis ISBN: 3319848828 ISBN-13(EAN): 9783319848822 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Поставка под заказ.
Описание: The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established.
Описание: The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases. There are fundamental aspects of metabolic homeostasis that are regulated differently in males and females, and influence both the development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men.
Автор: T. Godfraind; G. Mancia; M.P. Abbracchio; L. Aguil Название: Pharmacological Control of Calcium and Potassium Homeostasis ISBN: 9401040567 ISBN-13(EAN): 9789401040563 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: As the number of drugs acting on calcium and potassium channels grows, there is a need for a continuous reappraisal of the cellular machinery controlling them. Calcium homeostasis within the cell is not only regulated by calcium channels;
Автор: Andrew L. Snow; Michael J. Lenardo Название: Immune Homeostasis ISBN: 1493959689 ISBN-13(EAN): 9781493959686 Издательство: Springer Рейтинг: Цена: 16769.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines experimental techniques for measuring and analyzing immune cell dynamics, with an emphasizes lymphocyte programmed cell deaths in different contexts. It features expert tips and key implementation advice to guarantee successful results.
Автор: Richard Bucala; J?rgen Bernhagen Название: MIF Family Cytokines in Innate Immunity and Homeostasis ISBN: 331952352X ISBN-13(EAN): 9783319523521 Издательство: Springer Рейтинг: Цена: 22359.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The role of the cytokine macrophage migration inhibitory factor (MIF) in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well-established.
Автор: T. Godfraind; G. Mancia; M.P. Abbracchio; L. Aguil Название: Pharmacological Control of Calcium and Potassium Homeostasis ISBN: 0792336046 ISBN-13(EAN): 9780792336044 Издательство: Springer Рейтинг: Цена: 30606.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Gives a treatment of calcium and potassium channel pharmacology. This work first presents both molecular and preclinical pharmacology data, followed by contributions on the clinical application of the drugs that modulate calcium and potassium channels. It also includes chapters that discuss possible roles and application to the nervous system.
Автор: Andrew L. Snow; Michael J. Lenardo Название: Immune Homeostasis ISBN: 1627032894 ISBN-13(EAN): 9781627032896 Издательство: Springer Рейтинг: Цена: 15372.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book examines experimental techniques for measuring and analyzing immune cell dynamics, with an emphasizes lymphocyte programmed cell deaths in different contexts. It features expert tips and key implementation advice to guarantee successful results.
Автор: Joan Stein-Streilein Название: Infection, Immune Homeostasis and Immune Privilege ISBN: 303480797X ISBN-13(EAN): 9783034807975 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Organs and tissues that can tolerate little or no inflammation have developed multiple overlapping mechanisms of immune protection in the absence of inflammation. These areas have been designated “immune-privileged sites” by Peter Medawar and include the central nervous system, eye, reproductive tract, testis and possibly the liver. Mechanisms of immune homeostasis found in less immune-regulated organs are often evident in the immune privileged sites and vice versa. It is important that the non-inflammatory mechanisms that contribute to immune privilege allow host defense against infectious organisms. This volume highlights the mechanisms leading to immune privilege in tissues and organs, the deviation of immune responses and the modification of the behavior of the immune cells that manage to cross the blood barriers of tissues, in the context of infection.
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