Описание: This volume is the first collection of applications of proteomics to analyze various human body fluids. Proteomics of Human Bodyfluids consists of two parts: the first provides basic principles and strategies for proteomic analysis of human body fluids, while the second offers more details regarding methodologies and recent findings and clinical applications of each specific type of human body fluids.
Описание: In Functional Selectivity of G Protein-Coupled Receptors, experts review the work that demonstrated the existence of functional selectivity, placed it within a theoretical framework, and provided a mechanistic basis for the phenomenon.
Описание: Papers Presented at an International Workshop on Benzodia- zepine Receptor Ligands, Memory, and Information Processing, Held during the 15th CINP Meeting in Puerto Rico in December 1988
Автор: Marvin Jens Название: Dissecting Regulatory Interactions of RNA and Protein ISBN: 3319070819 ISBN-13(EAN): 9783319070810 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.
Автор: Mark C. Williams; L. James Maher, III Название: Biophysics of DNA-Protein Interactions ISBN: 1461426952 ISBN-13(EAN): 9781461426950 Издательство: Springer Рейтинг: Цена: 16977.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Focusing on the biophysics of DNA-protein interactions, this volume presents new methods and results that explore the mechanism behind prtein and DNA interaction. Recent advances in biophysics are discussed, in addition to proteins that alter DNA properties to faciliate interactions for transcription or replication.
1. Mass Spectrometry in Clinical Laboratory: Applications in Therapeutic Drug Monitoring and Toxicology Uttam Garg and Yan Victoria Zhang
2. Quantitation of Flecainide, Mexiletine, Propafenone, and Amiodarone in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Matthew H. Slawson and Kamisha L. Johnson-Davis 3. Quantitation of the Oral Anticoagulants Dabigatran, Rivaroxaban, Apixaban, and Warfarin in Plasma Using Ultra-Performance Liquid Chromatography with Tandem Mass Spectrometry (UPLC-MS/MS) Jaime H. Noguez and James C. Ritchie 4. Simultaneous Quantitation of Lamotrigine, Levetiracetam, 10-Hydroxycarbazepine, Topiramate, and Zonisamide in Serum Using HPLC-MS/MS Dean C. Carlow, Heng Shi, and Ryan C. Schofield 5. Quantification of the Triazole Antifungal Compounds Voriconazole and Posaconazole in Human Serum or Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS) Alejandro R. Molinelli and Charles H. Rose, IV 6. Quantitation of Haloperidol, Fluphenazine, Perphenazine, and Thiothixene in Serum or Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Matthew H. Slawson and Kamisha L. Johnson-Davis 7. Quantitation of Total Buprenorphine and Norbuprenorphine in Meconium by LC-MS/MS Stephanie J. Marin and Gwendolyn A. McMillin 8. Quantitation of Buprenorphine, Norbuprenorphine, Buprenorphine Glucuronide, Norbuprenorphine Glucuronide, and Naloxone in Urine by LC-MS/MS Stephanie J. Marin and Gwendolyn A. McMillin 9. A Simple Liquid Chromatography Tandem Mass Spectrometry Method for Quantification of Plasma Busulfan Shuang Deng, Michael Kiscoan, Clint Frazee, Susan Abdel-Rahman, Jignesh Dalal, and Uttam Garg 10. High-Throughput Quantitation of Busulfan in Plasma Using Ultra-Fast Solid Phase Extraction Tandem Mass Spectrometry (SPE-MS/MS) Loralie J. Langman, Darlington Danso, Enger Robert, and Paul J. Jannetto 11. Quantification of 11-Carboxy-Delta-9-Tetrahydrocannbinol (THC-COOH) in Meconium Using Gas Chromatography Mass Spectrometry (GC/MS) Judy Peat, Brehon Davis, Clint Frazee, and Uttam Garg 12. Quantitation of Carisoprodol and Meprobamate in Urine and Plasma Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Matthew H. Slawson and Kamisha L. Johnson-Davis 13. Cetirizine Quantification by High Performance Liquid Chromatography Tandem Mass Spectrometry (LC/MS/MS) Ada Munar, Clint Frazee, Bridgette Jones, and Uttam Garg 14. Quantification of Docetaxel in Serum Using Turbulent Flow Liquid Chromatography Electrospray Tandem Mass Spectrometry (TFC-HPLC-ESI-MS/MS) Christopher A. Crutchfield, Mark A. Marzinke and William Clarke 15. Comprehensive Urine Drug Screen by Gas-Chromatography Mass Spectrometry (GC/MS) Bheemraj Ramoo, Melissa Funke, Clint Frazee, and Uttam Garg 16. Broad Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry Judy Stone 17. High Resolution Mass Spectrometry for Untargeted Drug Screening Alan H.B. Wu and Jennifer Colby 18. Quantitation of Ethyl Glucuronide and Ethyl Sulfate in Urine Using Liquid Chromatography-Tandem Mass Spectrometry(LC-MS/MS) Matthew H. Slawson and Kamisha L. Johnson-Davis 19. Quantification of Hydroxychloroquine in Blood Using Turbulent Flow Liquid Chromatography-Tandem mass Soectrometry (TFLC-MS/MS) Allison B. Chambliss, Anna K. Fьzйry, and William A. Clarke 20. Quantification of Iohexol in Serum by High Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Faye B. Vicente, Gina Vespa, Alan Miller, and Shannon Haymond 21. Quantitation of Teriflunomide in Human Serum/Plasma Across a 4
Автор: Donev, Rossen Название: Protein Interactions As Targets In Drug Discovery,121 ISBN: 0128168463 ISBN-13(EAN): 9780128168462 Издательство: Elsevier Science Рейтинг: Цена: 21054.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Protein Interactions as Targets in Drug Discovery, Volume 121, is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis, Aromatic-aromatic interactions in protein-drug and protein-protein interactions, Role of protein-protein interaction in allosteric drug design within the human methyltransferome, and much more.
Автор: Alan H. Fielding Название: Machine Learning Methods for Ecological Applications ISBN: 1461374138 ISBN-13(EAN): 9781461374138 Издательство: Springer Рейтинг: Цена: 22203.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This is the first text aimed at introducing machine learning methods to a readership of professional ecologists. All but one of the chapters have been written by ecologists and biologists who highlight the application of a particular method to a particular class of problem.
Описание: Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations
The first book dedicated to the emerging field of physiologically-based pharmacokinetic modeling (PBPK)
Now in its second edition, Physiologically Based Pharmacokinetic (PBPK) Modelling and Simulations: Principles, Methods, and Applications in the Pharma Industry remains the premier reference book throughout the rapidly growing PBPK user community. Using clear and concise language, author Sheila Annie Peters connects theory with practice as she explores the vast potential of PBPK modeling for improving drug discovery and development.
This fully updated new edition covers key developments in the field of PBPK modelling and simulations that have emerged in recent years. A brand-new section provides case studies in different application areas of PBPK modelling, including drug-drug interaction, genetic polymorphism, renal impairment, and pediatric extrapolation. Additional chapters address topics such as model-informed drug development (MIDD) and expose readers to a wide range of current applications in the field. Throughout the book, substantially revised chapters simplify complex topics and offer a balanced view of both the opportunities and challenges of PBPK modelling. Providing timely and comprehensive coverage of one of the most exciting new areas of pharmaceutical science, this book:
Describes the principles behind physiological modeling of pharmacokinetic processes, inter-individual variability, and drug interactions for small molecule drugs and biologics
Features a wealth of new figures and case studies of the applications of PBPK modelling along the value chain in drug discovery and development
Reflects the latest regulatory guidelines on the reporting of PBPK modelling analysis
Includes access to a new companion website containing code, datasets, explanations of case examples in the text, and discussion of key developments in the field
Contains a brief overview of the field, end-of-chapter keywords for easy reference, and an extensive bibliography
Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry, Second Edition is an indispensable single-volume resource for beginning and intermediate practitioners across the pharmaceutical sciences in both industry and academia.
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