Описание: Completely updated and revised, the 28th edition of this best-selling reference provides instant access to the latest recommendations for treatment of infectious diseases in children. For each disease, the authors provide a commentary to help select the best of all antimicrobial choices.
Описание: This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) – teixobactin and the skyllamycins – with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.
Описание: This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery.
Автор: Jean-Michel M?rillon; C?line Riviere Название: Natural Antimicrobial Agents ISBN: 3030097862 ISBN-13(EAN): 9783030097868 Издательство: Springer Рейтинг: Цена: 21940.00 р. Наличие на складе: Нет в наличии.
Описание: Documenting the latest research in the field of different pathogenic organisms, this book presents the current scenario about promising antimicrobials in the following areas: Part I. Plants as source of antibacterials, Part II. Naturally occurring antifungal natural products, Part III. Antiparasitic natural products, Part IV. Antiviral natural products. Renowned scientists from the globe have been selected as authors to contribute chapters. Use of plants for various ailments is as old as human civilization and continuous efforts are being made to improve medicinal plants or to product their bioactive secondary metabolites in high amounts through various technologies. About 200,000 natural products of plant origin are known and many more are being identified from higher plants and micro-organisms. Some plants based drugs are used since centuries and there is no alternative medicine for many such drugs as cardiac glycosides. Drug discovery from medicinal plants or marine micro-organisms continues to provide an important source of new drug leads. Research on new antibacterials represents a real and timely challenge of this century, particularly for the treatment of infections caused by clinical isolates that show multidrug resistance. The main microorganisms involved in the resistance process have been identified and given the acronym ESKAPE for Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa and Enterobacteriaceae. Multidrug resistant Mycobacterium tuberculosis including highly drug-resistant strains (XDR-TB) has also emerged as one of the most important clinical challenges of this century. Plants of diverse taxa and marine micro-organisms are rich source of these antimicrobials. An attempt has been made to compile the recent information about natural sources of antibacterials and their sustainable utilization. Increased panic of these pathogens warrants a growing demand for research to undertake the threat of multidrug resistance. The search for new antifungal, antiparasitic and antiviral natural products is far from devoid of interest. According to the WHO report in 2013, malaria still represents some 207 million cases worldwide and more than 3 billion of people are still exposed to this risk. Similarly, about 350 million people are considered at risk of contracting leishmaniasis. The fight against some viruses also requires that the research on natural products continue. For example, even if an antiretroviral with direct action was recently approved in Europe in 2013, its high cost does not allow to offer it to an exposed population in countries where the cost of drugs remains a problem for a large part of the population. These books are useful to researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.
Автор: David A. Phoenix, Название: Novel Antimicrobial Agents and Strategies ISBN: 3527336389 ISBN-13(EAN): 9783527336388 Издательство: Wiley Рейтинг: Цена: 25336.00 р. Наличие на складе: Поставка под заказ.
Описание: A complete survey of current and future antimicrobial drugs and therapies, from small-molecule antibiotics to antimicrobial peptides and their engineered mimetics, from enzymes to nucleic acid therapeutics, and from metallic nanoparticles to photo- and sonosensitizers.
Автор: Finch, Roger; Davey, Peter; Wilcox, Mark H.; Irvin Название: Antimicrobial Chemotherapy ISBN: 0199697655 ISBN-13(EAN): 9780199697656 Издательство: Oxford Academ Цена: 6334.00 р. Наличие на складе: Поставка под заказ.
Описание: Antimicrobial agents are essential for the treatment of life-threatening infections and for managing the burden of minor infections in the community. In addition, they play a key role in organ and bone marrow transplantation, cancer chemotherapy, artificial joint and heart valve surgery. Unlike other classes of medicines, they are vulnerable to resistance from mutations in target microorganisms, and their adverse effects may extend to other patients (increased risk of cross-infection). As a consequence, there is a constant requirement for new agents, as well as practices that ensure the continued effective prescribing of licensed agents. Public awareness and concerns about drug resistant organisms has led to widespread publicity and political action in the UK, Europe and worldwide. The control of drug resistance and the implementation of good prescribing practice are now legal requirements in the UK as a result of the UK Health Act (2008). These fundamental changes underscore the ne
Автор: Alexander Vinks; Hartmut Derendorf; Johan Mouton ( Название: Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics ISBN: 0387756124 ISBN-13(EAN): 9780387756127 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The reader will be introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, and the translation of in vitro and animal model data to basic research and clinical situations in humans.
Автор: WilsonWilson Название: Mayo clinic antimicrobial therapy ISBN: 1420085182 ISBN-13(EAN): 9781420085181 Издательство: Informa Цена: 3177.00 р. Наличие на складе: Нет в наличии.
Описание: Direct from infectious diseases experts at Mayo Clinic, this new pocket-sized guide to antimicrobial therapy provides an innovative format organized for the way you treat patients?simplified treatment recommendations for specific syndromes at the point of care.Written in an easy-to-use format, the new Mayo Clinic Antimicrobial Therapy Quick Guide helps clinicians around the world improve their quick ID consults for positive patient outcomes.
Автор: Jeffrey K. Aronson Название: Meyler`s Side Effects of Antimicrobial Drugs, ISBN: 0444532722 ISBN-13(EAN): 9780444532725 Издательство: Elsevier Science Рейтинг: Цена: 8420.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Suitable for internal medicine physicians and general practitioners who prescribe antibiotic drugs, like penicillin and tetracycline that cure bacterial infections, and antiviral drugs used to treat patients with HIV and herpes viruses.
Автор: Ockelford, Adam Gray, Sophie Cohen, Jon Mai, Max Название: Antimicrobials in Pharmaceutical and Medicinal Research ISBN: 1032215534 ISBN-13(EAN): 9781032215532 Издательство: Taylor&Francis Рейтинг: Цена: 19140.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book deliberates recent developments in microbial science in combating infectious diseases and explores advances in antimicrobial constituents and their applications in the fight against bacteria.
Автор: Rai Название: Promising Antimicrobials from Natural Products ISBN: 3030835065 ISBN-13(EAN): 9783030835064 Издательство: Springer Рейтинг: Цена: 20962.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Given novel infectious diseases such as COVID-19 and antibiotic resistance new antimicrobial discovery is an important research area. Considering that nature is a vast source of bioactive molecules with antimicrobial activity, the main aim of this book is to present a comprehensive outlook of current research in the field of natural antimicrobials. It discusses the antimicrobial activity of medicinal plants, beehives, and mushrooms with a global coverage of antimicrobial agents from rich forests of Brazil (Amazon), North-Eastern forests of Peru, Argentina, Colombia, India, Bangladesh, Nepal, Middle East, Turkey, Croatia, Greece, Germany and Russia. The book covers the results of the in vitro screening of antimicrobial activities of extracts and isolated compounds from natural origins. It is divided into three sections: i) Section I, includes natural antimicrobials from plants; ii) Section II incorporates antimicrobial agents/secondary metabolites from plants, and (iii) Section III focuses on antimicrobials from mushrooms, beehive and delivery systems for different types of antimicrobials. Promising Antimicrobials From Natural Products is immensely useful for post graduate students, researchers in plant science, microbiology, biotechnology, pharmacology, pharma companies and those who are interested in herbal, eco-friendly, cost-effective and sustainable antimicrobials
Название: Antimicrobials ISBN: 0367377152 ISBN-13(EAN): 9780367377151 Издательство: Taylor&Francis Рейтинг: Цена: 9798.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
Antimicrobials: Synthetic and Natural Compounds summarizes the latest research regarding the possibilities of the most important natural antimicrobial compounds derived from various plant sources containing a wide variety of secondary metabolites. With collected contributions from international subject experts, it focuses primarily on natural products as a source of bioactive compounds that may be active against multidrug-resistant pathogens, providing an alternative to established antibiotics in controlling infectious diseases.
Covering a wide range of marine, microbial, and plant-origin antimicrobials, the book examines the usefulness of plant products containing antimicrobial molecules against bacteria, fungi, protozoa, and viruses. It also reports on unusual sources of antimicrobials such as animal fecal actinomycetes, actinobacteria, and cyanobacteria and discusses synthetic chemical compounds and biogenic nanoparticles.
The number of drug-resistant bacteria is increasing, posing a major problem to modern medicine. This book explores an important topic: finding and applying alternative means of pathogenic control and treatment via natural sources. It is an important source of information for microbiologists, biotechnologists, biochemists, pharmacologists, botanists, marine biologists, and others involved in research on natural and synthetic antimicrobial compounds. It is also a useful resource for scholars, scientists, academics, and students in various science disciplines.
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