Автор: Grutzmann Robert, Pilarsky Christian Название: Cancer Gene Profiling: Methods and Protocols ISBN: 1493979973 ISBN-13(EAN): 9781493979974 Издательство: Springer Рейтинг: Цена: 15998.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание:
1. Factors Affecting the Use of Human Tissues in Biomedical Research: Implications in the Design and Operation of a Biorepository Daniel S. Atherton, Katherine C. Sexton, Dennis Otali, Walter C. Bell, and William E. Grizzle
2. Tissue Microdissection Anja Rabien and Glen Kristiansen
3. Tissue Microarrays Ana-Maria Dancau, Ronald Simon, Martina Mirlacher, and Guido Sauter
4. Gene Expression Analysis in the Age of Mass Sequencing: An Introduction Christian Pilarsky, Lahiri Kanth Nanduri, and Janine Roy
5. Quantitative DNA Methylation in Cancer Ole Ammerpohl, Andrea Haake, Julia Kolarova, and Reiner Siebert
6. Single Nucleotide Polymorphism to Associate Cancer Risk Victoria Shaw, Katie Bullock, and William Greenhalf
7: Exosomes in Cancer Disease Margot Zцller
8: MicroRNAs (miRNAs) Profiling Lu Gao and Feng Jiang
9. Cancer Gene Profiling for Response Prediction B. Michael Ghadimi and Peter Jo
10. Target Gene Discovery for Novel Therapeutic Agents in Cancer Treatment Sanjay Tiwari, Ole Ammerpohl, and Holger Kalthoff
11. Application of Proteomics in Cancer Biomarker Discovery: GeLC-MS/MS Pedro R. Cutillas and Tatjana Crnogorac-Jurcevic
12. Meta-Analysis of Cancer Gene Profiling Data Janine Roy, Christof Winter, and Michael Schroeder
13. Reproducible, Scalable Fusion Gene Detection from RNA-Seq Vladan Arsenijevic and Brandi N. Davis-Dusenbery
14. Transcriptome Sequencing for the Detection of Chimeric Transcripts Hsueh-Ting Chu
Автор: Wei Wu Название: MicroRNA and Cancer ISBN: 1493984853 ISBN-13(EAN): 9781493984855 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Поставка под заказ.
Описание: This volume details basic principles of experimental and computational methods for the study of microRNAs in cancer research and, therefore, provides a firm grounding for those who wish to develop further applications. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, MicroRNA and Cancer: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field
Автор: Rani Название: MicroRNA Profiling ISBN: 1071628259 ISBN-13(EAN): 9781071628256 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Автор: Robert Gr?tzmann; Christian Pilarsky Название: Cancer Gene Profiling ISBN: 1493932039 ISBN-13(EAN): 9781493932030 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Cancer Gene Profiling
Автор: Simone Mocellin Название: Microarray Technology and Cancer Gene Profiling ISBN: 1441922989 ISBN-13(EAN): 9781441922984 Издательство: Springer Рейтинг: Цена: 27951.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Given the revolutionary implications that the use of this technology might have in the clinical management of cancer patients, the principles of DNA array-based tumor gene profiling must be clearly understood for the data to be correctly interpreted and appreciated.
Автор: Binnig, Gerd Huss, Ralf Schmidt, Gunter Название: Tissue phenomics: profiling cancer patients for treatment decisions ISBN: 981477488X ISBN-13(EAN): 9789814774888 Издательство: Taylor&Francis Рейтинг: Цена: 21284.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: In the age of digitization our society is transformed into a new state. In particular, machine intelligence dramatically elevates our capability to create and digest information. Naturally, healthcare is also impacted by this trend and will even be more transformed into a informatic driven discipline in the future. In the most important area of histo-pathology, the interpretation of tissue slices from cancer patients, informatics will have an early and huge impact on treatment decisions and probably will act as the leading discipline for this transformation in medicine. Tissue Phenomics provides a comprehensive methodology aiming at the discovery of the most accurate tissue-based decision support algorithm by close integration of assay development, image analysis and bioinformatics, and optimization feedback loops. In this book the methodology of Tissue Phenomics and its benefits and wealth’s are described. The different components of Tissue Phenomics are explained in the different chapters. In the chapters 2 to 4 of this book different authors describe various approaches on how to convert the wealth of tissue slide pixel data into mineable information using knowledge-based and data-driven image analysis methods. Subsequently, the datafication of images and the bioinformatics part plays a crucial role in generating prognostic and predictive models for disease progression. The integration of other data sources such as genomics, radiomics and patient related information is also important and is described as well. As discussed in chapters 5 and 6, these models may classify patients in distinct groups such as those responding to a given therapy. Since Tissue Phenomics provides a huge set of potentially prognostic features (phenes), one focus of both chapters is robust feature selection methods by advanced Monte-Carlo cross validation algorithms. In chapter 7 we discuss multiple application examples of Tissue Phenomics in academic and commercial settings and its tremendous impact to advances in biomedical sciences. Building on the successes in research, chapters 8 and 9 discuss applications in clinical environments and provide a flavor to the future envision in chapter 10, where tissue datafication and subsequent patient profiling is part of every routine examination, with the goal to best match patients with the most successful therapy, as predicted by tissue phenes.
Автор: Ulf Schmitz; Olaf Wolkenhauer; Julio Vera Название: MicroRNA Cancer Regulation ISBN: 9402400796 ISBN-13(EAN): 9789402400793 Издательство: Springer Рейтинг: Цена: 23508.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book discusses the role of microRNAs in the formation and progression of solid tumors. The main focus is on computational methods and applications, together with experimental techniques used to approach all aspects of microRNA regulation in cancer.
Автор: Mathias Munschauer Название: High-Resolution Profiling of Protein-RNA Interactions ISBN: 3319162527 ISBN-13(EAN): 9783319162522 Издательство: Springer Рейтинг: Цена: 18167.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel ‘protein occupancy profiling’ technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3’ UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universit?t Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany.
Автор: Singh Shree Ram Название: MicroRNA in Development and in the Progression of Cancer ISBN: 1489980644 ISBN-13(EAN): 9781489980649 Издательство: Springer Рейтинг: Цена: 23757.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-? and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.
Автор: Suresh Alahari Название: MicroRNA in Cancer ISBN: 9401784930 ISBN-13(EAN): 9789401784931 Издательство: Springer Рейтинг: Цена: 15672.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: This book explores the rapidly emerging field of microRNA biology, highlighting the importance of microRNAs in cancer. This first reference of its kind will benefit working scientists in cancer biology, as well as advanced undergraduate and graduate students.
Автор: Wei Wu Название: MicroRNA and Cancer ISBN: 1493974335 ISBN-13(EAN): 9781493974337 Издательство: Springer Рейтинг: Цена: 19564.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: Part I: Review
1. Non- coding RNAs in DNA Damage Response: Opportunities for Cancer Therapeutics
Wani Arjumand, Asia Asiaf, and Shiekh Tanveer Ahmad
2. MicroRNAs in Breast Cancer: Diagnostic and Therapeutic Potential
Asia Asiaf, Shiekh Tanveer Ahmad, Wani Arjumand, and Mohammad Afzal Zargar
3. Involvement of miRNAs and Pseudogenes in Cancer
Lьtfi TUTAR, Aykut ЦZGЬR, and Yusuf TUTAR
4. microRNAs Reprogram Tumor Immune Response
Wenfang Cheng and Wei Wu
5. APOBEC Gene Expression Regulated by microRNAs
Wei Cao and Wei Wu
6. MicroRNAs Changes the Landscape of Cancer Resistance
Jun Zhu and Wei Wu
7. MicroRNA, Noise, and Gene Expression Regulation
Wei Wu
PART II: Protocol Section
8. Deep Sequencing Reveals a microRNA Expression Signature in
Triple-negative Breast Cancer
Yao-Yin Chang, Liang-Chuan Lai, Mong-Hsun Tsai, and Eric Y. Chuang
9. Detection of Plasma microRNA Signature in Osteosarcoma Patients
Wendy Allen-Rhoades and Jason T. Yustein
10. Identification of E6/E7-dependent microRNAs in HPV-positive Cancer Cells
Anja Honegger, Daniela Schilling, Holger Sьltmann, Karin Hoppe-Seyler, and Felix Hoppe-Seyler
11. Combination of Anti-miRNAs Oligonucleotides with Low Amounts of Chemotherapeutic Agents for Pancreatic Cancer Therapy
Marta Passadouro and Henrique Faneca
12. Evaluation of microRNA Delivery in vivo
Rikki A. M. Brown, Kirsty L. Richardson, Felicity C. Kalinowski, Michael R. Epis, Jessica L. Horsham, Tasnuva D. Kabir, Marisa H. De Pinho, Dianne J. Beveridge, Lisa M. Stuart, Larissa C. Wintle, and Peter J. Leedman
13. Angiogenesis A
nalysis by in vitro Co-culture Assays in Transwell Chambers in Ovarian Cancer
Ali Flores-Pйrez, Dolores Gallardo Rincуn, Erika Ruiz-Garcнa, Raquel Echavarria, Laurence A. Marchat, Elizbeth Бlvarez-Sбnchez, and Cйsar Lуpez-Camarillo
14. Application of Individual qPCR Performance Parameters for Quality Control of Circulating microRNA Data
Anna Brunet-Vega, Marнa Elisa Quнlez, Marнa Josй Ramнrez-Lбzaro, andSergio Lario
15. Construction of Multi-potent microRNA Sponge and its Functional Evaluation
Suhwan Chang
16. microRNA Sequencing Data Analysis Toolkits
Wei Wu
Автор: Fazlul H. Sarkar Название: MicroRNA Targeted Cancer Therapy ISBN: 3319376063 ISBN-13(EAN): 9783319376066 Издательство: Springer Рейтинг: Цена: 19589.00 р. Наличие на складе: Есть у поставщика Поставка под заказ.
Описание: The most attractive feature of miRNAs is that one miRNA can regulate many target genes (mRNAs) and thus miRNA targeted therapy is highly promising because multiple genes could be regulated by targeting a single miRNA, which becomes very important for the killing of highly heterogeneous populations of cancer cells within a tumor mass.
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